3CSW
Crystal structure of a putative branched-chain amino acid aminotransferase (TM0831) from Thermotoga maritima at 2.15 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0008483 | molecular_function | transaminase activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| A | 0009097 | biological_process | isoleucine biosynthetic process |
| A | 0009098 | biological_process | L-leucine biosynthetic process |
| A | 0009099 | biological_process | valine biosynthetic process |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0046394 | biological_process | carboxylic acid biosynthetic process |
| A | 0050048 | molecular_function | L-leucine:2-oxoglutarate aminotransferase activity |
| A | 0052654 | molecular_function | L-leucine transaminase activity |
| A | 0052655 | molecular_function | L-valine transaminase activity |
| A | 0052656 | molecular_function | L-isoleucine transaminase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0008483 | molecular_function | transaminase activity |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| B | 0009097 | biological_process | isoleucine biosynthetic process |
| B | 0009098 | biological_process | L-leucine biosynthetic process |
| B | 0009099 | biological_process | valine biosynthetic process |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0046394 | biological_process | carboxylic acid biosynthetic process |
| B | 0050048 | molecular_function | L-leucine:2-oxoglutarate aminotransferase activity |
| B | 0052654 | molecular_function | L-leucine transaminase activity |
| B | 0052655 | molecular_function | L-valine transaminase activity |
| B | 0052656 | molecular_function | L-isoleucine transaminase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0008483 | molecular_function | transaminase activity |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| C | 0009097 | biological_process | isoleucine biosynthetic process |
| C | 0009098 | biological_process | L-leucine biosynthetic process |
| C | 0009099 | biological_process | valine biosynthetic process |
| C | 0019752 | biological_process | carboxylic acid metabolic process |
| C | 0046394 | biological_process | carboxylic acid biosynthetic process |
| C | 0050048 | molecular_function | L-leucine:2-oxoglutarate aminotransferase activity |
| C | 0052654 | molecular_function | L-leucine transaminase activity |
| C | 0052655 | molecular_function | L-valine transaminase activity |
| C | 0052656 | molecular_function | L-isoleucine transaminase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0008483 | molecular_function | transaminase activity |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009082 | biological_process | branched-chain amino acid biosynthetic process |
| D | 0009097 | biological_process | isoleucine biosynthetic process |
| D | 0009098 | biological_process | L-leucine biosynthetic process |
| D | 0009099 | biological_process | valine biosynthetic process |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0046394 | biological_process | carboxylic acid biosynthetic process |
| D | 0050048 | molecular_function | L-leucine:2-oxoglutarate aminotransferase activity |
| D | 0052654 | molecular_function | L-leucine transaminase activity |
| D | 0052655 | molecular_function | L-valine transaminase activity |
| D | 0052656 | molecular_function | L-isoleucine transaminase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PLP A 300 |
| Chain | Residue |
| A | ARG50 |
| A | ASN169 |
| A | LEU188 |
| A | GLY190 |
| A | ILE191 |
| A | THR192 |
| A | THR228 |
| A | LYS133 |
| A | ILE140 |
| A | ARG144 |
| A | GLU164 |
| A | GLY165 |
| A | SER166 |
| A | PHE167 |
| A | SER168 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PLP C 300 |
| Chain | Residue |
| C | ARG50 |
| C | LYS133 |
| C | GLU164 |
| C | SER166 |
| C | PHE167 |
| C | SER168 |
| C | ASN169 |
| C | LEU188 |
| C | GLY190 |
| C | ILE191 |
| C | THR192 |
| C | THR228 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UNL B 276 |
| Chain | Residue |
| B | ARG85 |
| B | HIS227 |
| B | THR228 |
| B | SER229 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UNL C 301 |
| Chain | Residue |
| C | THR33 |
| C | HIS227 |
| C | THR228 |
| C | SER229 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE UNL A 301 |
| Chain | Residue |
| A | THR33 |
| A | HIS227 |
| A | THR228 |
| A | SER229 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE UNL D 275 |
| Chain | Residue |
| D | THR33 |
| D | ARG85 |
| D | HIS227 |
| D | THR228 |
| D | SER229 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CIT A 302 |
| Chain | Residue |
| A | LEU142 |
| A | ARG145 |
| A | GLU146 |
| B | PHE57 |
| B | PHE58 |
| C | ASP67 |
| C | LYS71 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CIT D 276 |
| Chain | Residue |
| D | ARG122 |
| D | PRO124 |
| D | ASP125 |
| D | LEU126 |
| D | ASN159 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CIT B 277 |
| Chain | Residue |
| B | ARG122 |
| B | PRO124 |
| B | ASP125 |
| B | LEU126 |
| B | LEU158 |
| B | ASN159 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MPD A 303 |
| Chain | Residue |
| A | ASN159 |
| A | ASP184 |
| A | SER185 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MPD A 304 |
| Chain | Residue |
| A | ASP125 |
| A | PRO129 |
| B | ASN119 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE MPD C 303 |
| Chain | Residue |
| C | ASP184 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MPD B 278 |
| Chain | Residue |
| B | LYS52 |
| B | ASP56 |
| B | ASN59 |
| B | LEU60 |
| C | PHE66 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MPD B 279 |
| Chain | Residue |
| B | ASP125 |
| B | LEU126 |
| B | SER127 |
| B | THR128 |
| B | PRO129 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD D 277 |
| Chain | Residue |
| C | ASN119 |
| D | PHE57 |
| D | LEU126 |
| D | SER127 |
| D | THR128 |
| D | PRO129 |
Functional Information from PROSITE/UniProt
| site_id | PS00770 |
| Number of Residues | 30 |
| Details | AA_TRANSFER_CLASS_4 Aminotransferases class-IV signature. EgSfsNVFlvkegk......LiTpsldsgi.LdGItR |
| Chain | Residue | Details |
| A | GLU164-ARG193 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS133 | |
| B | LYS133 | |
| C | LYS133 | |
| D | LYS133 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1daa |
| Chain | Residue | Details |
| A | LYS133 | |
| A | GLU164 | |
| A | LEU188 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1daa |
| Chain | Residue | Details |
| B | LYS133 | |
| B | GLU164 | |
| B | LEU188 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1daa |
| Chain | Residue | Details |
| C | LYS133 | |
| C | GLU164 | |
| C | LEU188 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1daa |
| Chain | Residue | Details |
| D | LYS133 | |
| D | GLU164 | |
| D | LEU188 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1daa |
| Chain | Residue | Details |
| A | LYS133 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1daa |
| Chain | Residue | Details |
| B | LYS133 |
| site_id | CSA7 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1daa |
| Chain | Residue | Details |
| C | LYS133 |
| site_id | CSA8 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1daa |
| Chain | Residue | Details |
| D | LYS133 |
