3CSU

CATALYTIC TRIMER OF ESCHERICHIA COLI ASPARTATE TRANSCARBAMOYLASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004070	molecular_function	aspartate carbamoyltransferase activity
A	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006520	biological_process	amino acid metabolic process
A	0006541	biological_process	glutamine metabolic process
A	0009347	cellular_component	aspartate carbamoyltransferase complex
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
A	0042802	molecular_function	identical protein binding
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	0070207	biological_process	protein homotrimerization
B	0004070	molecular_function	aspartate carbamoyltransferase activity
B	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006520	biological_process	amino acid metabolic process
B	0006541	biological_process	glutamine metabolic process
B	0009347	cellular_component	aspartate carbamoyltransferase complex
B	0016597	molecular_function	amino acid binding
B	0016740	molecular_function	transferase activity
B	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
B	0042802	molecular_function	identical protein binding
B	0044205	biological_process	'de novo' UMP biosynthetic process
B	0070207	biological_process	protein homotrimerization
C	0004070	molecular_function	aspartate carbamoyltransferase activity
C	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006520	biological_process	amino acid metabolic process
C	0006541	biological_process	glutamine metabolic process
C	0009347	cellular_component	aspartate carbamoyltransferase complex
C	0016597	molecular_function	amino acid binding
C	0016740	molecular_function	transferase activity
C	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
C	0042802	molecular_function	identical protein binding
C	0044205	biological_process	'de novo' UMP biosynthetic process
C	0070207	biological_process	protein homotrimerization

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 311

Chain	Residue
B	ASP153
B	HOH484
B	HOH543
C	GLU216
C	ASP253
C	HOH450

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CA C 311

Chain	Residue
C	HOH428
C	HOH507
C	HOH568
C	HOH569
C	HOH584
C	GLY120
C	HOH320
C	HOH398

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Functional Information from PROSITE/UniProt

site_id	PS00097
Number of Residues	8
Details	CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FfEaSTRT

Chain	Residue	Details
A	PHE48-THR55

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	21
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00001, ECO:0000269|PubMed:3380787

Chain	Residue	Details
A	THR55
B	HIS106
B	PRO135
B	THR138
B	PRO268
B	ARG269
C	THR55
C	ARG56
C	HIS106
C	PRO135
C	THR138
A	ARG56
C	PRO268
C	ARG269
A	HIS106
A	PRO135
A	THR138
A	PRO268
A	ARG269
B	THR55
B	ARG56

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site_id	SWS_FT_FI2
Number of Residues	9
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00001, ECO:0000305|PubMed:3380787

Chain	Residue	Details
A	GLY85
A	THR168
A	VAL230
B	GLY85
B	THR168
B	VAL230
C	GLY85
C	THR168
C	VAL230

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1at1

Chain	Residue	Details
A	ARG54
A	HIS134
A	ARG105
A	THR55

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site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1at1

Chain	Residue	Details
B	ARG54
B	HIS134
B	ARG105
B	THR55

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site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1at1

Chain	Residue	Details
C	ARG54
C	HIS134
C	ARG105
C	THR55

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site_id	MCSA1
Number of Residues	5
Details	M-CSA 405

Chain	Residue	Details
A	THR55	electrostatic stabiliser
A	ARG56	electrostatic stabiliser, increase electrophilicity
A	GLY85	proton shuttle (general acid/base)
A	HIS106	electrostatic stabiliser, increase electrophilicity
A	PRO135	electrostatic stabiliser, increase electrophilicity

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site_id	MCSA2
Number of Residues	5
Details	M-CSA 405

Chain	Residue	Details
B	THR55	electrostatic stabiliser
B	ARG56	electrostatic stabiliser, increase electrophilicity
B	GLY85	proton shuttle (general acid/base)
B	HIS106	electrostatic stabiliser, increase electrophilicity
B	PRO135	electrostatic stabiliser, increase electrophilicity

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site_id	MCSA3
Number of Residues	5
Details	M-CSA 405

Chain	Residue	Details
C	THR55	electrostatic stabiliser
C	ARG56	electrostatic stabiliser, increase electrophilicity
C	GLY85	proton shuttle (general acid/base)
C	HIS106	electrostatic stabiliser, increase electrophilicity
C	PRO135	electrostatic stabiliser, increase electrophilicity

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