3CRV
XPD_Helicase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003678 | molecular_function | DNA helicase activity |
| A | 0003689 | molecular_function | DNA clamp loader activity |
| A | 0004386 | molecular_function | helicase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006281 | biological_process | DNA repair |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0009378 | molecular_function | four-way junction helicase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016818 | molecular_function | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0032508 | biological_process | DNA duplex unwinding |
| A | 0036121 | molecular_function | double-stranded DNA helicase activity |
| A | 0043139 | molecular_function | 5'-3' DNA helicase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| A | 0061749 | molecular_function | forked DNA-dependent helicase activity |
| A | 0061775 | molecular_function | cohesin loader activity |
| A | 0071103 | biological_process | DNA conformation change |
| A | 0140097 | molecular_function | catalytic activity, acting on DNA |
| A | 0140584 | molecular_function | chromatin extrusion motor activity |
| A | 0140588 | biological_process | chromatin looping |
| A | 0140665 | molecular_function | ATP-dependent H3-H4 histone complex chaperone activity |
| A | 0140849 | molecular_function | ATP-dependent H2AZ histone chaperone activity |
| A | 1990518 | molecular_function | single-stranded 3'-5' DNA helicase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FLC A 1900 |
| Chain | Residue |
| A | LYS369 |
| A | TYR473 |
| A | GLU496 |
| A | ARG531 |
| A | TRP537 |
| A | HOH717 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SF4 A 600 |
| Chain | Residue |
| A | CYS105 |
| A | LYS108 |
| A | CYS137 |
| A | CYS88 |
| A | ILE100 |
| A | CYS102 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE IPA A 1804 |
| Chain | Residue |
| A | GLY32 |
| A | SER33 |
| A | GLY34 |
| A | LYS35 |
| A | THR36 |
| A | HOH845 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IPA A 1806 |
| Chain | Residue |
| A | ASN21 |
| A | LYS530 |
| A | HOH826 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IPA A 1807 |
| Chain | Residue |
| A | SER357 |
| A | TYR358 |
| A | LYS542 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IPA A 1810 |
| Chain | Residue |
| A | HIS57 |
| A | GLY83 |
| A | THR155 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IPA A 1811 |
| Chain | Residue |
| A | SER368 |
| A | ILE471 |
| A | ARG531 |
| A | HOH614 |
| A | HOH701 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IPA A 1812 |
| Chain | Residue |
| A | ARG55 |
| A | ALA450 |
| A | GLU451 |
| A | GLY452 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 2000 |
| Chain | Residue |
| A | ARG373 |
| A | PRO401 |
| A | SER402 |
| A | GLU404 |
| A | ILE405 |
| A | TYR473 |
| A | HOH680 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541 |
| Chain | Residue | Details |
| A | ALA29 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18510924, ECO:0007744|PDB:3CRV, ECO:0007744|PDB:5H8C |
| Chain | Residue | Details |
| A | CYS88 | |
| A | CYS102 | |
| A | CYS105 | |
| A | CYS137 |
