3CPH

Crystal structure of Sec4 in complex with Rab-GDI

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000131	cellular_component	incipient cellular bud site
A	0000166	molecular_function	nucleotide binding
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005768	cellular_component	endosome
A	0005783	cellular_component	endoplasmic reticulum
A	0005886	cellular_component	plasma membrane
A	0005935	cellular_component	cellular bud neck
A	0006887	biological_process	exocytosis
A	0006893	biological_process	Golgi to plasma membrane transport
A	0006906	biological_process	vesicle fusion
A	0006914	biological_process	autophagy
A	0007107	biological_process	membrane addition at site of cytokinesis
A	0015031	biological_process	protein transport
A	0030133	cellular_component	transport vesicle
A	0030658	cellular_component	transport vesicle membrane
A	0031321	biological_process	ascospore-type prospore assembly
A	0031410	cellular_component	cytoplasmic vesicle
A	0031982	cellular_component	vesicle
A	0043332	cellular_component	mating projection tip
G	0005092	molecular_function	GDP-dissociation inhibitor activity
G	0005093	molecular_function	Rab GDP-dissociation inhibitor activity
G	0005096	molecular_function	GTPase activator activity
G	0005515	molecular_function	protein binding
G	0005575	cellular_component	cellular_component
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0007264	biological_process	small GTPase-mediated signal transduction
G	0015031	biological_process	protein transport
G	0016192	biological_process	vesicle-mediated transport
H	0005092	molecular_function	GDP-dissociation inhibitor activity
H	0005093	molecular_function	Rab GDP-dissociation inhibitor activity
H	0005096	molecular_function	GTPase activator activity
H	0005515	molecular_function	protein binding
H	0005575	cellular_component	cellular_component
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0007264	biological_process	small GTPase-mediated signal transduction
H	0015031	biological_process	protein transport
H	0016192	biological_process	vesicle-mediated transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 301

Chain	Residue
A	SER34
A	THR51

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site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GDP A 302

Chain	Residue
A	ASN46
A	PRO47
A	PHE49
A	ASN133
A	LYS134
A	ASP136
A	MET137
A	SER162
A	ALA163
A	LYS164
A	SER29
A	GLY30
A	GLY32
A	LYS33
A	SER34
A	CYS35
A	PHE45

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Functional Information from PROSITE/UniProt

site_id	PS00675
Number of Residues	14
Details	SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. ILLiGDSGVGKscL

Chain	Residue	Details
A	ILE23-LEU36

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	62
Details	Region: {"description":"Interaction with YPT1","evidences":[{"source":"PubMed","id":"14576435","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	11
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLN79

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site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLY30

---