3CMX
Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000725 | biological_process | recombinational repair |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003684 | molecular_function | damaged DNA binding |
| A | 0003697 | molecular_function | single-stranded DNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0006281 | biological_process | DNA repair |
| A | 0006310 | biological_process | DNA recombination |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008094 | molecular_function | ATP-dependent activity, acting on DNA |
| A | 0009355 | cellular_component | DNA polymerase V complex |
| A | 0009432 | biological_process | SOS response |
| A | 0010212 | biological_process | response to ionizing radiation |
| A | 0019985 | biological_process | translesion synthesis |
| A | 0035825 | biological_process | homologous recombination |
| A | 0048870 | biological_process | cell motility |
| A | 0140297 | molecular_function | DNA-binding transcription factor binding |
| A | 0140664 | molecular_function | ATP-dependent DNA damage sensor activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0000725 | biological_process | recombinational repair |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003684 | molecular_function | damaged DNA binding |
| D | 0003697 | molecular_function | single-stranded DNA binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006259 | biological_process | DNA metabolic process |
| D | 0006281 | biological_process | DNA repair |
| D | 0006310 | biological_process | DNA recombination |
| D | 0006974 | biological_process | DNA damage response |
| D | 0008094 | molecular_function | ATP-dependent activity, acting on DNA |
| D | 0009355 | cellular_component | DNA polymerase V complex |
| D | 0009432 | biological_process | SOS response |
| D | 0010212 | biological_process | response to ionizing radiation |
| D | 0019985 | biological_process | translesion synthesis |
| D | 0035825 | biological_process | homologous recombination |
| D | 0048870 | biological_process | cell motility |
| D | 0140297 | molecular_function | DNA-binding transcription factor binding |
| D | 0140664 | molecular_function | ATP-dependent DNA damage sensor activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 500 |
| Chain | Residue |
| A | THR73 |
| A | GLU96 |
| A | ASP144 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ALF A 501 |
| Chain | Residue |
| A | LYS1248 |
| A | LYS1250 |
| A | GLU68 |
| A | SER69 |
| A | LYS72 |
| A | THR73 |
| A | GLU96 |
| A | PHE1217 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 1500 |
| Chain | Residue |
| A | THR1073 |
| A | GLU1096 |
| A | ASP1144 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ALF A 1501 |
| Chain | Residue |
| A | GLU1068 |
| A | SER1069 |
| A | LYS1072 |
| A | THR1073 |
| A | GLU1096 |
| A | PHE2217 |
| A | LYS2248 |
| A | LYS2250 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 2500 |
| Chain | Residue |
| A | THR2073 |
| A | GLU2096 |
| A | ASP2144 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ALF A 2501 |
| Chain | Residue |
| A | GLU2068 |
| A | SER2069 |
| A | LYS2072 |
| A | THR2073 |
| A | GLU2096 |
| A | PHE3217 |
| A | LYS3248 |
| A | LYS3250 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 3500 |
| Chain | Residue |
| A | THR3073 |
| A | GLU3096 |
| A | ASP3144 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ALF A 3501 |
| Chain | Residue |
| A | GLU3068 |
| A | SER3069 |
| A | LYS3072 |
| A | THR3073 |
| A | GLU3096 |
| A | PHE4217 |
| A | LYS4248 |
| A | LYS4250 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 4500 |
| Chain | Residue |
| A | THR4073 |
| A | GLU4096 |
| A | ASP4144 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ALF A 4501 |
| Chain | Residue |
| A | GLU4068 |
| A | SER4069 |
| A | LYS4072 |
| A | THR4073 |
| A | GLU4096 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG D 500 |
| Chain | Residue |
| D | THR73 |
| D | GLU96 |
| D | ASP144 |
| site_id | BC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ALF D 501 |
| Chain | Residue |
| D | GLU68 |
| D | SER69 |
| D | LYS72 |
| D | THR73 |
| D | GLU96 |
| D | PHE1217 |
| D | LYS1248 |
| D | LYS1250 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG D 1500 |
| Chain | Residue |
| D | THR1073 |
| D | GLU1096 |
| D | ASP1144 |
| site_id | BC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ALF D 1501 |
| Chain | Residue |
| D | GLU1068 |
| D | SER1069 |
| D | LYS1072 |
| D | THR1073 |
| D | GLU1096 |
| D | PHE2217 |
| D | LYS2248 |
| D | LYS2250 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG D 2500 |
| Chain | Residue |
| D | THR2073 |
| D | GLU2096 |
| D | ASP2144 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ALF D 2501 |
| Chain | Residue |
| D | GLU2068 |
| D | SER2069 |
| D | LYS2072 |
| D | THR2073 |
| D | GLU2096 |
| D | PHE3217 |
| D | LYS3248 |
| D | LYS3250 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG D 3500 |
| Chain | Residue |
| D | THR3073 |
| D | GLU3096 |
| D | ASP3144 |
| D | LYS4250 |
| site_id | BC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ALF D 3501 |
| Chain | Residue |
| D | GLU3068 |
| D | SER3069 |
| D | LYS3072 |
| D | THR3073 |
| D | GLU3096 |
| D | PHE4217 |
| D | LYS4248 |
| D | LYS4250 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG D 4500 |
| Chain | Residue |
| D | ASP4144 |
| D | THR4073 |
| D | GLU4096 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ALF D 4501 |
| Chain | Residue |
| D | GLU4068 |
| D | SER4069 |
| D | LYS4072 |
| D | THR4073 |
| D | GLU4096 |
| site_id | CC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADP A 502 |
| Chain | Residue |
| A | SER69 |
| A | SER70 |
| A | GLY71 |
| A | LYS72 |
| A | THR73 |
| A | THR74 |
| A | ASP100 |
| A | TYR103 |
| A | TYR264 |
| A | ASN1249 |
| A | LYS1250 |
| A | ILE1251 |
| A | ALA1252 |
| A | ALA1253 |
| A | PRO1254 |
| site_id | CC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADP A 1502 |
| Chain | Residue |
| A | SER1069 |
| A | SER1070 |
| A | GLY1071 |
| A | LYS1072 |
| A | THR1073 |
| A | THR1074 |
| A | ASP1100 |
| A | TYR1103 |
| A | SER1240 |
| A | TYR1264 |
| A | ASN2249 |
| A | LYS2250 |
| A | ILE2251 |
| A | ALA2252 |
| A | ALA2253 |
| A | PRO2254 |
| site_id | CC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADP A 2502 |
| Chain | Residue |
| A | SER2069 |
| A | SER2070 |
| A | GLY2071 |
| A | LYS2072 |
| A | THR2073 |
| A | THR2074 |
| A | TYR2103 |
| A | SER2240 |
| A | TYR2264 |
| A | ASN3249 |
| A | LYS3250 |
| A | ILE3251 |
| A | ALA3252 |
| A | ALA3253 |
| A | PRO3254 |
| site_id | CC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ADP A 3502 |
| Chain | Residue |
| A | SER3069 |
| A | SER3070 |
| A | GLY3071 |
| A | LYS3072 |
| A | THR3073 |
| A | THR3074 |
| A | ASP3100 |
| A | TYR3103 |
| A | TYR3264 |
| A | ASN4249 |
| A | LYS4250 |
| A | ILE4251 |
| A | ALA4252 |
| A | ALA4253 |
| A | PRO4254 |
| site_id | CC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ADP A 4502 |
| Chain | Residue |
| A | SER4069 |
| A | SER4070 |
| A | GLY4071 |
| A | LYS4072 |
| A | THR4073 |
| A | THR4074 |
| A | ASP4100 |
| A | TYR4103 |
| A | TYR4264 |
| site_id | CC8 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADP D 502 |
| Chain | Residue |
| D | SER69 |
| D | SER70 |
| D | GLY71 |
| D | LYS72 |
| D | THR73 |
| D | THR74 |
| D | ASP100 |
| D | TYR103 |
| D | SER240 |
| D | TYR264 |
| D | ASN1249 |
| D | LYS1250 |
| D | ILE1251 |
| D | ALA1252 |
| D | ALA1253 |
| D | PRO1254 |
| site_id | CC9 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE ADP D 1502 |
| Chain | Residue |
| D | SER1069 |
| D | SER1070 |
| D | GLY1071 |
| D | LYS1072 |
| D | THR1073 |
| D | THR1074 |
| D | TYR1103 |
| D | SER1240 |
| D | TYR1264 |
| D | ASN2249 |
| D | ILE2251 |
| D | ALA2252 |
| D | ALA2253 |
| D | PRO2254 |
| site_id | DC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADP D 2502 |
| Chain | Residue |
| D | SER2069 |
| D | SER2070 |
| D | GLY2071 |
| D | LYS2072 |
| D | THR2073 |
| D | THR2074 |
| D | ASP2100 |
| D | TYR2103 |
| D | SER2240 |
| D | TYR2264 |
| D | ASN3249 |
| D | LYS3250 |
| D | ILE3251 |
| D | ALA3252 |
| D | ALA3253 |
| D | PRO3254 |
| site_id | DC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ADP D 3502 |
| Chain | Residue |
| D | SER3069 |
| D | SER3070 |
| D | GLY3071 |
| D | LYS3072 |
| D | THR3073 |
| D | THR3074 |
| D | ASP3100 |
| D | TYR3103 |
| D | SER3240 |
| D | TYR3264 |
| D | ASN4249 |
| D | LYS4250 |
| D | ILE4251 |
| D | ALA4252 |
| D | ALA4253 |
| D | PRO4254 |
| site_id | DC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE ADP D 4502 |
| Chain | Residue |
| A | LYS2294 |
| A | GLY2295 |
| D | SER4069 |
| D | SER4070 |
| D | GLY4071 |
| D | LYS4072 |
| D | THR4073 |
| D | THR4074 |
| D | ASP4100 |
| D | TYR4103 |
| D | TYR4264 |
Functional Information from PROSITE/UniProt
| site_id | PS00321 |
| Number of Residues | 9 |
| Details | RECA_1 recA signature. ALKFYASVR |
| Chain | Residue | Details |
| A | ALA214-ARG222 | |
| A | ALA1214-ARG1222 | |
| A | ALA2214-ARG2222 | |
| A | ALA3214-ARG3222 | |
| A | ALA4214-ARG4222 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00268","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1731253","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
