Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3CMW

Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000725	biological_process	recombinational repair
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006259	biological_process	DNA metabolic process
A	0006281	biological_process	DNA repair
A	0006310	biological_process	DNA recombination
A	0006974	biological_process	DNA damage response
A	0008094	molecular_function	ATP-dependent activity, acting on DNA
A	0009432	biological_process	SOS response
A	0010212	biological_process	response to ionizing radiation
A	0019985	biological_process	translesion synthesis
A	0035825	biological_process	homologous recombination
A	0048870	biological_process	cell motility
A	0140297	molecular_function	DNA-binding transcription factor binding
A	0140664	molecular_function	ATP-dependent DNA damage sensor activity
C	0000166	molecular_function	nucleotide binding
C	0000725	biological_process	recombinational repair
C	0003677	molecular_function	DNA binding
C	0003684	molecular_function	damaged DNA binding
C	0003697	molecular_function	single-stranded DNA binding
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006259	biological_process	DNA metabolic process
C	0006281	biological_process	DNA repair
C	0006310	biological_process	DNA recombination
C	0006974	biological_process	DNA damage response
C	0008094	molecular_function	ATP-dependent activity, acting on DNA
C	0009432	biological_process	SOS response
C	0010212	biological_process	response to ionizing radiation
C	0019985	biological_process	translesion synthesis
C	0035825	biological_process	homologous recombination
C	0048870	biological_process	cell motility
C	0140297	molecular_function	DNA-binding transcription factor binding
C	0140664	molecular_function	ATP-dependent DNA damage sensor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 500

Chain	Residue
A	THR73
A	GLU96

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ALF A 501

Chain	Residue
A	GLU68
A	SER69
A	LYS72
A	GLU96
A	PHE1217
A	LYS1248
A	LYS1250

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 1500

Chain	Residue
A	THR1073
A	GLU1096
A	ASP1144

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ALF A 1501

Chain	Residue
A	GLU1068
A	SER1069
A	LYS1072
A	GLU1096
A	PHE2217
A	LYS2248
A	LYS2250

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 2500

Chain	Residue
A	THR2073
A	GLU2096

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ALF A 2501

Chain	Residue
A	GLU2068
A	SER2069
A	LYS2072
A	GLU2096
A	PHE3217
A	LYS3248
A	LYS3250

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 3500

Chain	Residue
A	THR3073
A	GLU3096

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ALF A 3501

Chain	Residue
A	GLU3068
A	SER3069
A	LYS3072
A	GLU3096
A	PHE4217
A	LYS4248
A	LYS4250

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG A 4500

Chain	Residue
A	THR4073
A	GLU4096

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ALF A 4501

Chain	Residue
A	GLU4068
A	SER4069
A	LYS4072
A	GLU4096

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG C 500

Chain	Residue
C	THR73
C	GLU96

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ALF C 501

Chain	Residue
C	GLU68
C	SER69
C	LYS72
C	GLU96
C	PHE1217
C	LYS1248
C	LYS1250

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG C 1500

Chain	Residue
C	THR1073
C	GLU1096

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ALF C 1501

Chain	Residue
C	GLU1068
C	SER1069
C	LYS1072
C	GLU1096
C	PHE2217
C	LYS2248
C	LYS2250

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG C 2500

Chain	Residue
C	THR2073
C	GLU2096

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ALF C 2501

Chain	Residue
C	GLU2068
C	SER2069
C	LYS2072
C	GLU2096
C	PHE3217
C	LYS3248
C	LYS3250

site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG C 3500

Chain	Residue
C	THR3073

site_id	BC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ALF C 3501

Chain	Residue
C	GLU3068
C	SER3069
C	LYS3072
C	GLU3096
C	PHE4217
C	LYS4248
C	LYS4250

site_id	CC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG C 4500

Chain	Residue
C	THR4073
C	GLU4096

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ALF C 4501

Chain	Residue
C	GLU4068
C	SER4069
C	LYS4072
C	GLU4096

site_id	CC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP A 502

Chain	Residue
A	PRO1254
A	SER69
A	SER70
A	GLY71
A	LYS72
A	THR73
A	THR74
A	ASP100
A	TYR103
A	SER240
A	TYR264
A	ASN1249
A	LYS1250
A	ILE1251
A	ALA1252
A	ALA1253

site_id	CC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP A 1502

Chain	Residue
A	SER1069
A	SER1070
A	GLY1071
A	LYS1072
A	THR1073
A	THR1074
A	ASP1100
A	TYR1103
A	SER1240
A	TYR1264
A	ASN2249
A	LYS2250
A	ILE2251
A	ALA2252
A	ALA2253
A	PRO2254

site_id	CC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ADP A 2502

Chain	Residue
A	SER2069
A	SER2070
A	GLY2071
A	LYS2072
A	THR2073
A	THR2074
A	ASP2100
A	TYR2103
A	SER2240
A	TYR2264
A	ASN3249
A	LYS3250
A	ALA3252
A	ALA3253
A	PRO3254

site_id	CC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP A 3502

Chain	Residue
A	SER3069
A	SER3070
A	GLY3071
A	LYS3072
A	THR3073
A	THR3074
A	ASP3100
A	TYR3103
A	SER3240
A	TYR3264
A	ASN4249
A	LYS4250
A	ILE4251
A	ALA4252
A	ALA4253
A	PRO4254

site_id	CC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ADP A 4502

Chain	Residue
A	SER4069
A	SER4070
A	GLY4071
A	LYS4072
A	THR4073
A	THR4074
A	TYR4103
A	SER4240
A	TYR4264

site_id	CC8
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP C 502

Chain	Residue
C	SER69
C	SER70
C	GLY71
C	LYS72
C	THR73
C	THR74
C	ASP100
C	TYR103
C	SER240
C	TYR264
C	ASN1249
C	LYS1250
C	ILE1251
C	ALA1252
C	ALA1253
C	PRO1254

site_id	CC9
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP C 1502

Chain	Residue
C	SER1069
C	SER1070
C	GLY1071
C	LYS1072
C	THR1073
C	THR1074
C	ASP1100
C	TYR1103
C	SER1240
C	TYR1264
C	ASN2249
C	LYS2250
C	ILE2251
C	ALA2252
C	ALA2253
C	PRO2254

site_id	DC1
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP C 2502

Chain	Residue
C	SER2069
C	SER2070
C	GLY2071
C	LYS2072
C	THR2073
C	THR2074
C	ASP2100
C	TYR2103
C	SER2240
C	TYR2264
C	ASN3249
C	LYS3250
C	ILE3251
C	ALA3252
C	ALA3253
C	PRO3254

site_id	DC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP C 3502

Chain	Residue
C	SER3069
C	SER3070
C	GLY3071
C	LYS3072
C	THR3073
C	THR3074
C	ASP3100
C	TYR3103
C	SER3240
C	TYR3264
C	ASN4249
C	LYS4250
C	ILE4251
C	ALA4252
C	ALA4253
C	PRO4254

site_id	DC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ADP C 4502

Chain	Residue
A	LYS2294
A	GLY2295
C	SER4069
C	SER4070
C	GLY4071
C	LYS4072
C	THR4073
C	THR4074
C	ASP4100
C	TYR4103
C	TYR4264

Functional Information from PROSITE/UniProt

site_id	PS00321
Number of Residues	9
Details	RECA_1 recA signature. ALKFYASVR

Chain	Residue	Details
A	ALA214-ARG222
A	ALA1214-ARG1222
A	ALA2214-ARG2222
A	ALA3214-ARG3222
A	ALA4214-ARG4222

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00268","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1731253","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)