3CM6

Crystal structure of cell-death related nuclease 4 (CRN-4) bound with Er

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000175	molecular_function	3'-5'-RNA exonuclease activity
A	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A	0003676	molecular_function	nucleic acid binding
A	0003697	molecular_function	single-stranded DNA binding
A	0004520	molecular_function	DNA endonuclease activity
A	0004527	molecular_function	exonuclease activity
A	0004536	molecular_function	DNA nuclease activity
A	0004540	molecular_function	RNA nuclease activity
A	0005737	cellular_component	cytoplasm
A	0006308	biological_process	DNA catabolic process
A	0006309	biological_process	apoptotic DNA fragmentation
A	0006401	biological_process	RNA catabolic process
A	0006915	biological_process	apoptotic process
A	0008408	molecular_function	3'-5' exonuclease activity
A	0046872	molecular_function	metal ion binding
B	0000175	molecular_function	3'-5'-RNA exonuclease activity
B	0000467	biological_process	exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B	0003676	molecular_function	nucleic acid binding
B	0003697	molecular_function	single-stranded DNA binding
B	0004520	molecular_function	DNA endonuclease activity
B	0004527	molecular_function	exonuclease activity
B	0004536	molecular_function	DNA nuclease activity
B	0004540	molecular_function	RNA nuclease activity
B	0005737	cellular_component	cytoplasm
B	0006308	biological_process	DNA catabolic process
B	0006309	biological_process	apoptotic DNA fragmentation
B	0006401	biological_process	RNA catabolic process
B	0006915	biological_process	apoptotic process
B	0008408	molecular_function	3'-5' exonuclease activity
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 299

Chain	Residue
A	CYS210
A	CYS260
A	CYS263
A	CYS270

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ER3 A 300

Chain	Residue
A	ASP15
A	PHE16
A	GLU17
A	ASP184

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 299

Chain	Residue
B	CYS260
B	CYS263
B	CYS270
B	CYS210

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site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ER3 B 300

Chain	Residue
B	ASP15
B	GLU17
B	ASP184

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:27529560, ECO:0007744|PDB:5DK5

Chain	Residue	Details
A	ASP15
A	GLU17
A	ASP184
B	ASP15
B	GLU17
B	ASP184

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site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:18981218, ECO:0000269|PubMed:27529560, ECO:0007744|PDB:3CG7, ECO:0007744|PDB:3CM5, ECO:0007744|PDB:3CM6, ECO:0007744|PDB:5DK5

Chain	Residue	Details
A	CYS210
A	CYS260
A	CYS263
A	CYS270
B	CYS210
B	CYS260
B	CYS263
B	CYS270

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