3CM3
High Resolution Crystal Structure of the Vaccinia Virus Dual-Specificity Phosphatase VH1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| A | 0004722 | molecular_function | protein serine/threonine phosphatase activity |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0016311 | biological_process | dephosphorylation |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016791 | molecular_function | phosphatase activity |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0039502 | biological_process | symbiont-mediated suppression of host type I interferon-mediated signaling pathway |
| A | 0039563 | biological_process | symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity |
| A | 0044423 | cellular_component | virion component |
| A | 0052031 | biological_process | symbiont-mediated perturbation of host defense response |
| A | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1 |
| Chain | Residue |
| A | ASP1081 |
| A | SER1112 |
| A | ALA1113 |
| A | ALA1114 |
| A | GLY1115 |
| A | ASN1117 |
| A | ARG1118 |
| A | HOH1199 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE BME A 1174 |
| Chain | Residue |
| A | GLU1156 |
| A | ASN1157 |
| A | HOH1251 |
| A | HOH1391 |
| A | ASN1117 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE BME A 2 |
| Chain | Residue |
| A | ASN1131 |
| A | LYS1132 |
| A | SER1134 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1848923","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
