3CL5
Structure of coronavirus hemagglutinin-esterase in complex with 4,9-O-diacetyl sialic acid
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001681 | molecular_function | sialate O-acetylesterase activity |
| A | 0002683 | biological_process | negative regulation of immune system process |
| A | 0005102 | molecular_function | signaling receptor binding |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| A | 0019031 | cellular_component | viral envelope |
| A | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| A | 0020002 | cellular_component | host cell plasma membrane |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0044423 | cellular_component | virion component |
| A | 0046789 | molecular_function | host cell surface receptor binding |
| A | 0046813 | biological_process | receptor-mediated virion attachment to host cell |
| A | 0055036 | cellular_component | virion membrane |
| A | 0106330 | molecular_function | sialate 9-O-acetylesterase activity |
| A | 0106331 | molecular_function | sialate 4-O-acetylesterase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 138 |
| Details | Region: {"description":"Receptor binding","evidences":[{"source":"HAMAP-Rule","id":"MF_04207","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_04207","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18550812","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"HAMAP-Rule","id":"MF_04207","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04207","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18550812","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04207","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
