3CL4

Crystal structure of bovine coronavirus hemagglutinin-esterase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001681	molecular_function	sialate O-acetylesterase activity
A	0002683	biological_process	negative regulation of immune system process
A	0005102	molecular_function	signaling receptor binding
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0016788	molecular_function	hydrolase activity, acting on ester bonds
A	0019031	cellular_component	viral envelope
A	0019064	biological_process	fusion of virus membrane with host plasma membrane
A	0020002	cellular_component	host cell plasma membrane
A	0033644	cellular_component	host cell membrane
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0044423	cellular_component	virion component
A	0046789	molecular_function	host cell surface receptor binding
A	0046813	biological_process	receptor-mediated virion attachment to host cell
A	0055036	cellular_component	virion membrane
A	0106330	molecular_function	sialate 9-O-acetylesterase activity
A	0106331	molecular_function	sialate 4-O-acetylesterase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_04207, ECO:0000269|PubMed:18550812

Chain	Residue	Details
A	SER40

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Charge relay system => ECO:0000255|HAMAP-Rule:MF_04207

Chain	Residue	Details
A	ASP326
A	HIS329

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site_id	SWS_FT_FI3
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04207, ECO:0000269|PubMed:18550812

Chain	Residue	Details
A	ASN54
A	ASN89
A	ASN236
A	ASN301
A	ASN316
A	ASN358

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255|HAMAP-Rule:MF_04207

Chain	Residue	Details
A	ASN153

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