Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3CIS

The Crystal Structure of Rv2623 from Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001666	biological_process	response to hypoxia
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0040008	biological_process	regulation of growth
A	0085014	biological_process	dormancy entry of symbiont in host
B	0001666	biological_process	response to hypoxia
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0040008	biological_process	regulation of growth
B	0085014	biological_process	dormancy entry of symbiont in host
C	0001666	biological_process	response to hypoxia
C	0005524	molecular_function	ATP binding
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0040008	biological_process	regulation of growth
C	0085014	biological_process	dormancy entry of symbiont in host
D	0001666	biological_process	response to hypoxia
D	0005524	molecular_function	ATP binding
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0009274	cellular_component	peptidoglycan-based cell wall
D	0040008	biological_process	regulation of growth
D	0085014	biological_process	dormancy entry of symbiont in host
E	0001666	biological_process	response to hypoxia
E	0005524	molecular_function	ATP binding
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0009274	cellular_component	peptidoglycan-based cell wall
E	0040008	biological_process	regulation of growth
E	0085014	biological_process	dormancy entry of symbiont in host
F	0001666	biological_process	response to hypoxia
F	0005524	molecular_function	ATP binding
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0009274	cellular_component	peptidoglycan-based cell wall
F	0040008	biological_process	regulation of growth
F	0085014	biological_process	dormancy entry of symbiont in host
G	0001666	biological_process	response to hypoxia
G	0005524	molecular_function	ATP binding
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0009274	cellular_component	peptidoglycan-based cell wall
G	0040008	biological_process	regulation of growth
G	0085014	biological_process	dormancy entry of symbiont in host
H	0001666	biological_process	response to hypoxia
H	0005524	molecular_function	ATP binding
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0009274	cellular_component	peptidoglycan-based cell wall
H	0040008	biological_process	regulation of growth
H	0085014	biological_process	dormancy entry of symbiont in host

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG A 1002

Chain	Residue
A	ASP198

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG C 1002

Chain	Residue
C	ASP198

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG D 2002

Chain	Residue
D	ASP198

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG E 1002

Chain	Residue
E	ASP198

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG F 2002

Chain	Residue
F	ASP198

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG G 1002

Chain	Residue
G	ASP198

site_id	AC9
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ATP A 1101

Chain	Residue
A	SER17
A	ALA20
A	ALA43
A	GLY117
A	LEU119
A	GLY120
A	SER121
A	GLY122
A	ARG123
A	ARG127
A	GLY130
A	SER131
A	SER133
A	GLY13
A	ILE14
A	ASP15

site_id	BC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ATP A 1102

Chain	Residue
A	GLY165
A	ASP167
A	SER172
A	LEU193
A	ALA195
A	ASP198
A	PRO245
A	GLY262
A	ARG264
A	GLY265
A	ARG266
A	GLY267
A	GLY268
A	MET272
A	GLY275
A	SER276
A	GLY278

site_id	BC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ATP B 2101

Chain	Residue
B	GLY13
B	ILE14
B	ASP15
B	SER17
B	ALA20
B	ALA43
B	ALA100
B	LEU104
B	GLY117
B	LEU119
B	GLY120
B	SER121
B	GLY122
B	ARG123
B	ARG127
B	GLY130
B	SER131
B	SER133

site_id	BC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ATP B 2102

Chain	Residue
B	GLY165
B	ASP167
B	SER172
B	LEU193
B	ALA195
B	ASP198
B	PRO245
B	GLY262
B	ARG264
B	GLY265
B	ARG266
B	GLY267
B	GLY268
B	MET272
B	GLY275
B	SER276
B	GLY278

site_id	BC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ATP C 1101

Chain	Residue
C	GLY13
C	ILE14
C	ASP15
C	SER17
C	ALA20
C	ALA43
C	GLY117
C	LEU119
C	GLY120
C	SER121
C	GLY122
C	ARG123
C	ARG127
C	GLY130
C	SER131
C	SER133

site_id	BC5
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ATP C 1102

Chain	Residue
C	ARG264
C	GLY265
C	GLY267
C	GLY268
C	MET272
C	GLY275
C	SER276
C	GLY278
C	GLY165
C	ASP167
C	SER172
C	LEU193
C	HIS194
C	ALA195
C	ASP198
C	PRO245
C	GLY262

site_id	BC6
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ATP D 2101

Chain	Residue
D	GLY13
D	ILE14
D	ASP15
D	SER17
D	ALA20
D	ALA43
D	ALA100
D	LEU104
D	GLY117
D	LEU119
D	GLY120
D	SER121
D	GLY122
D	ARG123
D	ARG127
D	GLY130
D	SER131
D	SER133

site_id	BC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ATP D 2102

Chain	Residue
D	GLY165
D	ASP167
D	LEU193
D	ALA195
D	ASP198
D	PRO245
D	GLY262
D	ARG264
D	GLY265
D	ARG266
D	GLY267
D	GLY268
D	MET272
D	GLY275
D	SER276
D	GLY278

site_id	BC8
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ATP E 1101

Chain	Residue
E	GLY13
E	ILE14
E	ASP15
E	SER17
E	ALA20
E	ALA43
E	GLY117
E	LEU119
E	GLY120
E	SER121
E	GLY122
E	ARG123
E	ARG127
E	GLY130
E	SER131
E	SER133

site_id	BC9
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ATP E 1102

Chain	Residue
E	GLY165
E	ASP167
E	SER172
E	LEU193
E	ALA195
E	ASP198
E	PRO245
E	GLY262
E	ARG264
E	GLY265
E	GLY267
E	GLY268
E	MET272
E	GLY275
E	SER276
E	GLY278

site_id	CC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ATP F 2101

Chain	Residue
F	GLY13
F	ILE14
F	ASP15
F	SER17
F	ALA43
F	GLY117
F	LEU119
F	GLY120
F	SER121
F	GLY122
F	ARG123
F	ARG127
F	GLY130
F	SER131
F	SER133

site_id	CC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ATP F 2102

Chain	Residue
F	GLY165
F	ASP167
F	LEU193
F	ALA195
F	ASP198
F	PRO245
F	GLY262
F	ARG264
F	GLY265
F	ARG266
F	GLY267
F	GLY268
F	MET272
F	GLY275
F	SER276
F	GLY278

site_id	CC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ATP G 1101

Chain	Residue
G	GLY13
G	ILE14
G	ASP15
G	SER17
G	ALA20
G	ALA43
G	GLY117
G	LEU119
G	GLY120
G	SER121
G	GLY122
G	ARG123
G	ARG127
G	GLY130
G	SER131
G	SER133

site_id	CC4
Number of Residues	18
Details	BINDING SITE FOR RESIDUE ATP G 1102

Chain	Residue
G	GLY165
G	ASP167
G	SER172
G	LEU193
G	HIS194
G	ALA195
G	ASP198
G	PRO245
G	GLY262
G	ARG264
G	GLY265
G	ARG266
G	GLY267
G	GLY268
G	MET272
G	GLY275
G	SER276
G	GLY278

site_id	CC5
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ATP H 2101

Chain	Residue
H	GLY13
H	ILE14
H	ASP15
H	SER17
H	ALA20
H	ALA43
H	ALA100
H	GLY117
H	LEU119
H	GLY120
H	SER121
H	GLY122
H	ARG123
H	ARG127
H	GLY130
H	SER131
H	SER133

site_id	CC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ATP H 2102

Chain	Residue
H	GLY165
H	ASP167
H	SER172
H	LEU193
H	ALA195
H	ASP198
H	PRO245
H	GLY262
H	ARG264
H	GLY265
H	ARG266
H	GLY267
H	GLY268
H	MET272
H	GLY275
H	SER276
H	GLY278

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	BINDING: BINDING => ECO:0000269\|Ref.11, ECO:0000269\|Ref.12, ECO:0007744\|PDB:2JAX, ECO:0007744\|PDB:3CIS

Chain	Residue	Details
A	GLY13
B	GLY13
B	ALA43
B	GLY117
B	ARG127
B	SER131
B	GLY165
B	ASP198
B	GLY262
B	SER276
C	GLY13
A	ALA43
C	ALA43
C	GLY117
C	ARG127
C	SER131
C	GLY165
C	ASP198
C	GLY262
C	SER276
D	GLY13
D	ALA43
A	GLY117
D	GLY117
D	ARG127
D	SER131
D	GLY165
D	ASP198
D	GLY262
D	SER276
E	GLY13
E	ALA43
E	GLY117
A	ARG127
E	ARG127
E	SER131
E	GLY165
E	ASP198
E	GLY262
E	SER276
F	GLY13
F	ALA43
F	GLY117
F	ARG127
A	SER131
F	SER131
F	GLY165
F	ASP198
F	GLY262
F	SER276
G	GLY13
G	ALA43
G	GLY117
G	ARG127
G	SER131
A	GLY165
G	GLY165
G	ASP198
G	GLY262
G	SER276
H	GLY13
H	ALA43
H	GLY117
H	ARG127
H	SER131
H	GLY165
A	ASP198
H	ASP198
H	GLY262
H	SER276
A	GLY262
A	SER276

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)