3CC9
Crystal structure of Plasmodium vivax putative polyprenyl pyrophosphate synthase in complex with geranylgeranyl diphosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| A | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| B | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| B | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| C | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| C | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| C | 0004659 | molecular_function | prenyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0008299 | biological_process | isoprenoid biosynthetic process |
| C | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| C | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| D | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| D | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| D | 0004659 | molecular_function | prenyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0008299 | biological_process | isoprenoid biosynthetic process |
| D | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| D | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA A 502 |
| Chain | Residue |
| A | ASN83 |
| A | ARG84 |
| A | GLU116 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE GRG B 501 |
| Chain | Residue |
| B | PHE122 |
| B | LEU123 |
| B | MET129 |
| B | ARG135 |
| B | ARG136 |
| B | THR188 |
| B | THR191 |
| B | GLN195 |
| B | LYS243 |
| B | TYR247 |
| B | PHE283 |
| A | ASN154 |
| A | LEU157 |
| B | GLY80 |
| B | LYS81 |
| B | ARG84 |
| B | GLN119 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE GRG A 501 |
| Chain | Residue |
| A | GLY80 |
| A | LYS81 |
| A | ARG84 |
| A | GLN119 |
| A | PHE122 |
| A | MET129 |
| A | ARG135 |
| A | ARG136 |
| A | THR188 |
| A | THR191 |
| A | ILE192 |
| A | GLN195 |
| A | LYS243 |
| A | TYR247 |
| A | PHE283 |
| B | ASN154 |
| B | LEU157 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE GRG D 501 |
| Chain | Residue |
| C | ASN154 |
| C | LEU157 |
| D | GLY80 |
| D | LYS81 |
| D | ARG84 |
| D | GLN119 |
| D | PHE122 |
| D | LEU123 |
| D | MET129 |
| D | ARG135 |
| D | ARG136 |
| D | THR188 |
| D | THR191 |
| D | GLN195 |
| D | LYS243 |
| D | TYR247 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE GRG C 501 |
| Chain | Residue |
| C | GLY80 |
| C | LYS81 |
| C | ARG84 |
| C | GLN119 |
| C | PHE122 |
| C | MET129 |
| C | ARG135 |
| C | ARG136 |
| C | GLN195 |
| C | TYR247 |
| C | PHE283 |
| D | ASN154 |
| D | LEU157 |
Functional Information from PROSITE/UniProt
| site_id | PS00444 |
| Number of Residues | 13 |
| Details | POLYPRENYL_SYNTHASE_2 Polyprenyl synthases signature 2. MGeyFQIhDDYlD |
| Chain | Residue | Details |
| A | MET279-ASP291 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fps |
| Chain | Residue | Details |
| A | ARG135 | |
| A | PHE283 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fps |
| Chain | Residue | Details |
| B | ARG135 | |
| B | PHE283 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fps |
| Chain | Residue | Details |
| C | ARG135 | |
| C | PHE283 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fps |
| Chain | Residue | Details |
| D | ARG135 | |
| D | PHE283 |
