3C6G

Crystal structure of CYP2R1 in complex with vitamin D3

Replaces:  2OJD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005737	cellular_component	cytoplasm
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006082	biological_process	organic acid metabolic process
A	0006629	biological_process	lipid metabolic process
A	0006766	biological_process	vitamin metabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0010038	biological_process	response to metal ion
A	0010164	biological_process	response to cesium ion
A	0010212	biological_process	response to ionizing radiation
A	0016491	molecular_function	oxidoreductase activity
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
A	0020037	molecular_function	heme binding
A	0030343	molecular_function	vitamin D3 25-hydroxylase activity
A	0036378	biological_process	calcitriol biosynthetic process from calciol
A	0042359	biological_process	vitamin D metabolic process
A	0042368	biological_process	vitamin D biosynthetic process
A	0042803	molecular_function	protein homodimerization activity
A	0046872	molecular_function	metal ion binding
A	1902271	molecular_function	D3 vitamins binding
B	0004497	molecular_function	monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0005737	cellular_component	cytoplasm
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006082	biological_process	organic acid metabolic process
B	0006629	biological_process	lipid metabolic process
B	0006766	biological_process	vitamin metabolic process
B	0006805	biological_process	xenobiotic metabolic process
B	0010038	biological_process	response to metal ion
B	0010164	biological_process	response to cesium ion
B	0010212	biological_process	response to ionizing radiation
B	0016491	molecular_function	oxidoreductase activity
B	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B	0016712	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
B	0020037	molecular_function	heme binding
B	0030343	molecular_function	vitamin D3 25-hydroxylase activity
B	0036378	biological_process	calcitriol biosynthetic process from calciol
B	0042359	biological_process	vitamin D metabolic process
B	0042368	biological_process	vitamin D biosynthetic process
B	0042803	molecular_function	protein homodimerization activity
B	0046872	molecular_function	metal ion binding
B	1902271	molecular_function	D3 vitamins binding

Functional Information from PROSITE/UniProt

site_id	PS00086
Number of Residues	10
Details	CYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FSlGRRHCLG

Chain	Residue	Details
A	PHE441-GLY450

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18511070","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"18511070","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1akd

Chain	Residue	Details
A	GLU313
A	THR314

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1akd

Chain	Residue	Details
B	GLU313
B	THR314

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