3C61
Crystal structure of dihydroorotate dehydrogenase from Leishmania donovani
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0006222 | biological_process | UMP biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| A | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0006222 | biological_process | UMP biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| C | 0006222 | biological_process | UMP biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| C | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| C | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| D | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| D | 0006222 | biological_process | UMP biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| D | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| D | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL D 314 |
| Chain | Residue |
| D | PRO57 |
| D | ARG58 |
| D | TYR59 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 314 |
| Chain | Residue |
| A | PRO57 |
| A | ARG58 |
| A | TYR59 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 314 |
| Chain | Residue |
| B | GLY272 |
| B | THR273 |
| B | ALA274 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 315 |
| Chain | Residue |
| B | PRO57 |
| B | ARG58 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL C 314 |
| Chain | Residue |
| C | PRO57 |
| C | ARG58 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 315 |
| Chain | Residue |
| A | THR34 |
| A | TYR83 |
| A | ASP89 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL C 315 |
| Chain | Residue |
| C | THR34 |
| C | TYR83 |
| C | ASP89 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL D 315 |
| Chain | Residue |
| D | THR34 |
| D | TYR83 |
| D | ASP89 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL C 316 |
| Chain | Residue |
| C | THR254 |
| C | GLY255 |
| C | GLU256 |
| C | GLU289 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 317 |
| Chain | Residue |
| B | THR34 |
| B | TYR83 |
| B | ASP89 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE AZI A 317 |
| Chain | Residue |
| A | ALA115 |
| A | THR119 |
| C | ARG224 |
| C | TYR253 |
| site_id | BC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE FMN A 401 |
| Chain | Residue |
| A | ALA19 |
| A | ALA20 |
| A | GLY21 |
| A | LYS44 |
| A | SER45 |
| A | ASN68 |
| A | MET70 |
| A | ASN128 |
| A | LYS165 |
| A | ILE194 |
| A | ASN195 |
| A | SER196 |
| A | GLY223 |
| A | CYS249 |
| A | GLY250 |
| A | GLY251 |
| A | GLY272 |
| A | THR273 |
| site_id | BC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE ORO A 501 |
| Chain | Residue |
| A | LYS44 |
| A | ASN68 |
| A | MET70 |
| A | GLY71 |
| A | LEU72 |
| A | ASN128 |
| A | CYS131 |
| A | PRO132 |
| A | ASN133 |
| A | ASN195 |
| A | SER196 |
| site_id | BC5 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE FMN B 401 |
| Chain | Residue |
| B | ALA19 |
| B | ALA20 |
| B | GLY21 |
| B | SER45 |
| B | TYR59 |
| B | ASN68 |
| B | MET70 |
| B | ASN128 |
| B | LYS165 |
| B | ILE194 |
| B | ASN195 |
| B | SER196 |
| B | GLY223 |
| B | CYS249 |
| B | GLY250 |
| B | GLY251 |
| B | GLY272 |
| B | THR273 |
| site_id | BC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE ORO B 501 |
| Chain | Residue |
| B | ASN68 |
| B | MET70 |
| B | GLY71 |
| B | LEU72 |
| B | PRO73 |
| B | ASN128 |
| B | CYS131 |
| B | PRO132 |
| B | ASN133 |
| B | ASN195 |
| B | SER196 |
| site_id | BC7 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE FMN C 401 |
| Chain | Residue |
| C | ASN128 |
| C | LYS165 |
| C | ILE194 |
| C | ASN195 |
| C | SER196 |
| C | GLY223 |
| C | CYS249 |
| C | GLY250 |
| C | GLY251 |
| C | GLY272 |
| C | THR273 |
| C | ALA19 |
| C | ALA20 |
| C | GLY21 |
| C | LYS44 |
| C | SER45 |
| C | TYR59 |
| C | ASN68 |
| C | MET70 |
| site_id | BC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE ORO C 501 |
| Chain | Residue |
| C | LYS44 |
| C | ASN68 |
| C | MET70 |
| C | GLY71 |
| C | LEU72 |
| C | PRO73 |
| C | ASN128 |
| C | CYS131 |
| C | PRO132 |
| C | ASN133 |
| C | ASN195 |
| C | SER196 |
| site_id | BC9 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE FMN D 401 |
| Chain | Residue |
| D | ALA19 |
| D | ALA20 |
| D | GLY21 |
| D | LYS44 |
| D | SER45 |
| D | ASN68 |
| D | MET70 |
| D | ASN128 |
| D | LYS165 |
| D | ILE194 |
| D | ASN195 |
| D | SER196 |
| D | GLY223 |
| D | CYS249 |
| D | GLY250 |
| D | GLY251 |
| D | GLY272 |
| D | THR273 |
| site_id | CC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE ORO D 501 |
| Chain | Residue |
| D | LYS44 |
| D | ASN68 |
| D | MET70 |
| D | GLY71 |
| D | LEU72 |
| D | ASN128 |
| D | CYS131 |
| D | PRO132 |
| D | ASN133 |
| D | ASN195 |
| D | SER196 |
| site_id | CC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE DTU D 502 |
| Chain | Residue |
| C | TYR169 |
| C | PHE170 |
| C | ASP171 |
| C | HIS174 |
| D | TYR142 |
| D | TYR169 |
| D | PHE170 |
| D | ASP171 |
| D | HIS174 |
| site_id | CC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DTU A 502 |
| Chain | Residue |
| A | TYR142 |
| A | PHE170 |
| A | ASP171 |
| A | HIS174 |
| B | TYR142 |
| B | PHE170 |
| B | ASP171 |
| B | HIS174 |
| site_id | CC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 1002 |
| Chain | Residue |
| A | LEU227 |
| A | PRO228 |
| A | LEU231 |
| B | ILE203 |
| B | TYR225 |
| D | GLU156 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C 1001 |
| Chain | Residue |
| A | GLU156 |
| C | ILE203 |
| C | TYR225 |
| D | LEU227 |
| D | PRO228 |
| D | LEU231 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2dor |
| Chain | Residue | Details |
| A | LYS44 | |
| A | CYS131 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2dor |
| Chain | Residue | Details |
| B | LYS44 | |
| B | CYS131 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2dor |
| Chain | Residue | Details |
| C | LYS44 | |
| C | CYS131 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 2dor |
| Chain | Residue | Details |
| D | LYS44 | |
| D | CYS131 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 2dor |
| Chain | Residue | Details |
| A | CYS131 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 2dor |
| Chain | Residue | Details |
| B | CYS131 |
| site_id | CSA7 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 2dor |
| Chain | Residue | Details |
| C | CYS131 |
| site_id | CSA8 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 2dor |
| Chain | Residue | Details |
| D | CYS131 |
