3C5I
Crystal structure of Plasmodium knowlesi choline kinase, PKH_134520
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004103 | molecular_function | choline kinase activity |
| A | 0004305 | molecular_function | ethanolamine kinase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006646 | biological_process | phosphatidylethanolamine biosynthetic process |
| A | 0006656 | biological_process | phosphatidylcholine biosynthetic process |
| A | 0006657 | biological_process | CDP-choline pathway |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004103 | molecular_function | choline kinase activity |
| B | 0004305 | molecular_function | ethanolamine kinase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006646 | biological_process | phosphatidylethanolamine biosynthetic process |
| B | 0006656 | biological_process | phosphatidylcholine biosynthetic process |
| B | 0006657 | biological_process | CDP-choline pathway |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004103 | molecular_function | choline kinase activity |
| C | 0004305 | molecular_function | ethanolamine kinase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006646 | biological_process | phosphatidylethanolamine biosynthetic process |
| C | 0006656 | biological_process | phosphatidylcholine biosynthetic process |
| C | 0006657 | biological_process | CDP-choline pathway |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004103 | molecular_function | choline kinase activity |
| D | 0004305 | molecular_function | ethanolamine kinase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006646 | biological_process | phosphatidylethanolamine biosynthetic process |
| D | 0006656 | biological_process | phosphatidylcholine biosynthetic process |
| D | 0006657 | biological_process | CDP-choline pathway |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 370 |
| Chain | Residue |
| A | ASN223 |
| A | ASP235 |
| A | HOH1037 |
| A | HOH1038 |
| A | HOH1039 |
| A | HOH1040 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 371 |
| Chain | Residue |
| A | TYR259 |
| A | GLU221 |
| A | GLU254 |
| A | ILE257 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 370 |
| Chain | Residue |
| B | ASN223 |
| B | ASP235 |
| B | HOH1036 |
| B | HOH1046 |
| B | HOH1067 |
| B | HOH1070 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA B 371 |
| Chain | Residue |
| B | GLU221 |
| B | GLU254 |
| B | ILE257 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 370 |
| Chain | Residue |
| C | ASN223 |
| C | ASP235 |
| C | HOH402 |
| C | HOH453 |
| C | HOH472 |
| C | HOH476 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA C 371 |
| Chain | Residue |
| C | ILE123 |
| C | GLU221 |
| C | GLU254 |
| C | ILE257 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG D 370 |
| Chain | Residue |
| D | ASN223 |
| D | ASP235 |
| D | HOH380 |
| D | HOH409 |
| D | HOH414 |
| D | HOH417 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA D 371 |
| Chain | Residue |
| D | GLU221 |
| D | GLU254 |
| D | ILE257 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CHT A 1001 |
| Chain | Residue |
| A | ASP218 |
| A | GLN220 |
| A | GLU254 |
| A | TYR259 |
| A | TRP322 |
| A | TRP325 |
| A | TYR344 |
| A | HOH1035 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CHT B 1001 |
| Chain | Residue |
| B | ASP218 |
| B | GLN220 |
| B | GLU254 |
| B | TYR259 |
| B | TRP322 |
| B | TRP325 |
| B | TYR344 |
| B | ARG348 |
| B | HOH1072 |
| site_id | BC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNL B 1002 |
| Chain | Residue |
| B | MET351 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE UNL C 372 |
| Chain | Residue |
| C | GLN220 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE UNL D 372 |
| Chain | Residue |
| D | LYS163 |
| D | GOL375 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1002 |
| Chain | Residue |
| A | TRP155 |
| A | ASP156 |
| A | GLY240 |
| A | PHE241 |
| A | HOH1014 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1003 |
| Chain | Residue |
| A | ILE253 |
| A | SER256 |
| A | LYS271 |
| A | HIS319 |
| A | MET351 |
| A | GLN355 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 1003 |
| Chain | Residue |
| B | TRP155 |
| B | ASP156 |
| B | THR158 |
| B | CYS160 |
| B | LYS163 |
| B | PHE214 |
| B | GLY240 |
| B | PHE241 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 1004 |
| Chain | Residue |
| B | HIS77 |
| B | GLU80 |
| B | TYR175 |
| B | GLN332 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL C 373 |
| Chain | Residue |
| C | HIS30 |
| C | PHE31 |
| C | THR32 |
| C | ASN35 |
| C | TYR62 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C 374 |
| Chain | Residue |
| C | ASP156 |
| C | THR158 |
| C | CYS160 |
| C | LYS163 |
| C | GLY240 |
| C | PHE241 |
| site_id | CC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL C 375 |
| Chain | Residue |
| E | PHE6 |
| C | TYR264 |
| C | ASP340 |
| C | HOH497 |
| E | ASN3 |
| E | LEU4 |
| E | TYR5 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 373 |
| Chain | Residue |
| D | VAL90 |
| D | TRP155 |
| D | ASP156 |
| D | GLY240 |
| D | PHE241 |
| D | HOH448 |
| site_id | CC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 374 |
| Chain | Residue |
| D | ASP218 |
| D | GLN220 |
| D | TYR259 |
| D | TRP322 |
| D | TRP325 |
| D | HOH464 |
| site_id | CC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL D 375 |
| Chain | Residue |
| D | LEU81 |
| D | TYR82 |
| D | CYS160 |
| D | MET164 |
| D | TYR238 |
| D | UNL372 |
| D | HOH384 |
| D | HOH443 |
