3C4Y
Crystal Structure of Apo form of G protein coupled receptor kinase 1 at 7.51A
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001750 | cellular_component | photoreceptor outer segment |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004674 | molecular_function | protein serine/threonine kinase activity |
A | 0004703 | molecular_function | G protein-coupled receptor kinase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0006468 | biological_process | protein phosphorylation |
A | 0007165 | biological_process | signal transduction |
A | 0007601 | biological_process | visual perception |
A | 0009966 | biological_process | regulation of signal transduction |
A | 0016020 | cellular_component | membrane |
A | 0016310 | biological_process | phosphorylation |
A | 0022400 | biological_process | regulation of opsin-mediated signaling pathway |
A | 0042995 | cellular_component | cell projection |
A | 0046777 | biological_process | protein autophosphorylation |
A | 0050254 | molecular_function | rhodopsin kinase activity |
A | 0097381 | cellular_component | photoreceptor disc membrane |
B | 0001750 | cellular_component | photoreceptor outer segment |
B | 0004672 | molecular_function | protein kinase activity |
B | 0004674 | molecular_function | protein serine/threonine kinase activity |
B | 0004703 | molecular_function | G protein-coupled receptor kinase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0006468 | biological_process | protein phosphorylation |
B | 0007165 | biological_process | signal transduction |
B | 0007601 | biological_process | visual perception |
B | 0009966 | biological_process | regulation of signal transduction |
B | 0016020 | cellular_component | membrane |
B | 0016310 | biological_process | phosphorylation |
B | 0022400 | biological_process | regulation of opsin-mediated signaling pathway |
B | 0042995 | cellular_component | cell projection |
B | 0046777 | biological_process | protein autophosphorylation |
B | 0050254 | molecular_function | rhodopsin kinase activity |
B | 0097381 | cellular_component | photoreceptor disc membrane |
Functional Information from PROSITE/UniProt
site_id | PS00107 |
Number of Residues | 24 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGGFGEVFaCqmkatgkl..........YACK |
Chain | Residue | Details |
A | LEU193-LYS216 |
site_id | PS00108 |
Number of Residues | 13 |
Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiYrDLKpeNVLL |
Chain | Residue | Details |
A | ILE310-LEU322 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 |
Chain | Residue | Details |
A | ASP314 | |
B | ASP314 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:18339619 |
Chain | Residue | Details |
A | LEU193 | |
B | LEU193 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
Chain | Residue | Details |
A | LYS216 | |
B | LYS216 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18339619 |
Chain | Residue | Details |
A | THR265 | |
A | ASP332 | |
B | THR265 | |
B | ASP332 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:18339619 |
Chain | Residue | Details |
A | SER5 | |
B | SER5 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0000269|PubMed:18339619 |
Chain | Residue | Details |
A | THR8 | |
B | THR8 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by PKA and autocatalysis => ECO:0000305|PubMed:1527025, ECO:0000305|PubMed:18339619 |
Chain | Residue | Details |
A | SER21 | |
B | SER21 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:1527025, ECO:0000269|PubMed:18339619 |
Chain | Residue | Details |
A | SER488 | |
B | SER488 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:1527025, ECO:0000269|PubMed:18339619 |
Chain | Residue | Details |
A | THR489 | |
B | THR489 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | ASP314 | |
A | GLU318 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
B | ASP314 | |
B | GLU318 |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | LYS316 | |
A | ASP314 |
site_id | CSA4 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
B | LYS316 | |
B | ASP314 |
site_id | CSA5 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | LYS316 | |
A | THR352 | |
A | ASP314 |
site_id | CSA6 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
B | LYS316 | |
B | THR352 | |
B | ASP314 |
site_id | CSA7 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
A | LYS316 | |
A | ASN319 | |
A | ASP314 |
site_id | CSA8 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1ir3 |
Chain | Residue | Details |
B | LYS316 | |
B | ASN319 | |
B | ASP314 |