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3C4T

Structure of RNaseIIIb and dsRNA binding domains of mouse Dicer

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0004525molecular_functionribonuclease III activity
A0006364biological_processrRNA processing
A0006396biological_processRNA processing
A0030422biological_processsiRNA processing
A0031054biological_processpre-miRNA processing
Functional Information from PDB Data
site_idAC1
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CD A 1
ChainResidue
AHIS1703

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CD A 2
ChainResidue
AHIS1645
AGLU1762

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CD A 3
ChainResidue
AGLU1689
AASP1794
AGLU1797

Functional Information from PROSITE/UniProt
site_idPS00517
Number of Residues9
DetailsRNASE_3_1 Ribonuclease III family signature. QRLEFLGDA
ChainResidueDetails
AGLN1686-ALA1694

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q9UPY3
ChainResidueDetails
ALEU1699
ATYR1804
ASER1807

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Important for activity => ECO:0000269|PubMed:18268334
ChainResidueDetails
AALA1800

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9UPY3
ChainResidueDetails
AVAL1862

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PDB entries from 2024-11-06

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