3C4E

Pim-1 Kinase Domain in Complex with 3-aminophenyl-7-azaindole

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0043066	biological_process	negative regulation of apoptotic process
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
B	0043066	biological_process	negative regulation of apoptotic process
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
C	0043066	biological_process	negative regulation of apoptotic process
D	0004672	molecular_function	protein kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation
D	0043066	biological_process	negative regulation of apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IMD A 1

Chain	Residue
A	PHE130
A	THR134
A	ASP170
A	ASP234
A	GLY238
A	ASP239

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE IMD B 2

Chain	Residue
B	ASP170
B	ASP234
B	GLY238
B	ASP239
B	PHE130
B	ILE133
B	THR134

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE IMD C 3

Chain	Residue
C	PHE130
C	THR134
C	ASP170
C	ASP234
C	GLY238

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE IMD D 4

Chain	Residue
D	PHE130
D	ILE133
D	THR134
D	ASP170
D	ASP234
D	GLY238
D	ASP239

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE C4E A 306

Chain	Residue
A	PHE49
A	ALA65
A	LYS67
A	ILE104
A	GLU121
A	ARG122
A	LEU174
A	ASP186

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE C4E B 306

Chain	Residue
B	PHE49
B	ALA65
B	LYS67
B	GLU121
B	ARG122
B	LEU174
B	ILE185
B	ASP186

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE C4E C 306

Chain	Residue
C	LEU44
C	PHE49
C	ALA65
C	LYS67
C	GLU121
C	ARG122
C	LEU174
C	ILE185
C	ASP186

---

site_id	AC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE C4E D 306

Chain	Residue
D	LEU44
D	PHE49
D	ALA65
D	LYS67
D	ILE104
D	GLU121
D	ARG122
D	LEU174
D	ILE185
D	ASP186

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGSGGFGSVYsGirvsdnlp..........VAIK

Chain	Residue	Details
A	LEU44-LYS67

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDIKdeNILI

Chain	Residue	Details
A	VAL163-ILE175

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP76
B	ASP76
C	ASP76
D	ASP76

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305|PubMed:15525646, ECO:0000305|PubMed:15657054, ECO:0000305|PubMed:15808862

Chain	Residue	Details
A	GLN37
B	GLN37
C	GLN37
D	GLN37

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:15657054

Chain	Residue	Details
A	ASP170
B	ASP170
C	ASP170
D	ASP170

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP167
A	GLU171

---

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	THR204
B	LYS169
B	ASP167

---

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	THR204
C	LYS169
C	ASP167

---

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	THR204
D	LYS169
D	ASP167

---

site_id	CSA13
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASN172
A	LYS169
A	ASP167

---

site_id	CSA14
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASN172
B	LYS169
B	ASP167

---

site_id	CSA15
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASN172
C	LYS169
C	ASP167

---

site_id	CSA16
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASN172
D	LYS169
D	ASP167

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP167
B	GLU171

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP167
C	GLU171

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP167
D	GLU171

---

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	LYS169
A	ASP167

---

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	LYS169
B	ASP167

---

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	LYS169
C	ASP167

---

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	LYS169
D	ASP167

---

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	THR204
A	LYS169
A	ASP167

---