3C0N

Crystal structure of the proaerolysin mutant Y221G at 2.2 A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001897	biological_process	symbiont-mediated cytolysis of host cell
A	0005576	cellular_component	extracellular region
A	0016020	cellular_component	membrane
A	0020002	cellular_component	host cell plasma membrane
A	0033644	cellular_component	host cell membrane
A	0035821	biological_process	modulation of process of another organism
A	0042802	molecular_function	identical protein binding
A	0090729	molecular_function	toxin activity
B	0001897	biological_process	symbiont-mediated cytolysis of host cell
B	0005576	cellular_component	extracellular region
B	0016020	cellular_component	membrane
B	0020002	cellular_component	host cell plasma membrane
B	0033644	cellular_component	host cell membrane
B	0035821	biological_process	modulation of process of another organism
B	0042802	molecular_function	identical protein binding
B	0090729	molecular_function	toxin activity

Functional Information from PROSITE/UniProt

site_id	PS00274
Number of Residues	10
Details	AEROLYSIN Aerolysin type toxins signature. TatNWskTNT

Chain	Residue	Details
A	THR223-THR232

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site_id	PS00387
Number of Residues	7
Details	PPASE Inorganic pyrophosphatase signature. DGDEVDV

Chain	Residue	Details
A	ASP95-VAL101

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Important for oligomerization

Chain	Residue	Details
A	HIS132
B	HIS132

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site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Important for heptamerization

Chain	Residue	Details
A	LYS351
A	GLU367
B	LYS351
B	GLU367

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