3BZH
Crystal structure of human ubiquitin-conjugating enzyme E2 E1
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000151 | cellular_component | ubiquitin ligase complex |
A | 0000209 | biological_process | protein polyubiquitination |
A | 0004842 | molecular_function | ubiquitin-protein transferase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
A | 0016567 | biological_process | protein ubiquitination |
A | 0016740 | molecular_function | transferase activity |
A | 0019787 | molecular_function | ubiquitin-like protein transferase activity |
A | 0032020 | biological_process | ISG15-protein conjugation |
A | 0042296 | molecular_function | ISG15 transferase activity |
A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
A | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
A | 0070936 | biological_process | protein K48-linked ubiquitination |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE GOL A 200 |
Chain | Residue |
A | LYS112 |
A | ILE130 |
A | LEU135 |
A | HOH215 |
A | HOH258 |
Functional Information from PROSITE/UniProt
site_id | PS00183 |
Number of Residues | 16 |
Details | UBC_1 Ubiquitin-conjugating (UBC) active site signature. YHCNInsq.GvICLdiL |
Chain | Residue | Details |
A | TYR120-LEU135 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Glycyl thioester intermediate => ECO:0000255|PROSITE-ProRule:PRU00388, ECO:0000255|PROSITE-ProRule:PRU10133 |
Chain | Residue | Details |
A | CYS131 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: N-acetylserine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:21406692 |
Chain | Residue | Details |
A | SER2 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15) |
Chain | Residue | Details |
A | LYS136 |