3BT9

crystal structure of QacR(E57Q) bound to Dequalinium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0045892	biological_process	negative regulation of DNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0045892	biological_process	negative regulation of DNA-templated transcription
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0045892	biological_process	negative regulation of DNA-templated transcription
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0045892	biological_process	negative regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 599

Chain	Residue
A	ASN2
A	ASP5
A	LYS6

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 299

Chain	Residue
A	LYS4
A	TYR41
A	HIS42

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 899

Chain	Residue
D	LYS46
D	THR23
D	THR24
D	THR25

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 900

Chain	Residue
E	LYS36
E	TYR40
E	THR45
E	LYS46

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 269

Chain	Residue
B	LYS66
D	ASN38

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 270

Chain	Residue
D	LYS17
D	GLU27

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 249

Chain	Residue
E	TYR20
E	THR45
E	LYS46
E	GLU47
E	TYR106

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 699

Chain	Residue
A	SER35
A	LYS36
E	LYS60

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 999

Chain	Residue
D	TYR20
D	LYS46
D	GLU105
D	TYR106

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 399

Chain	Residue
E	LYS12
E	ILE53
E	ILE56
E	GLN57
E	LYS60

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 799

Chain	Residue
A	TYR40
E	ASN2
E	ASP5
E	LYS6

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 800

Chain	Residue
A	THR23
A	THR24
A	THR25
A	LYS46

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 499

Chain	Residue
B	LYS67
D	LYS60
D	TYR91

---

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 801

Chain	Residue
A	HIS128
A	LYS132

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 279

Chain	Residue
A	ASN2
A	LEU3
A	LYS4
A	ASN38
A	HIS42

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 280

Chain	Residue
B	LYS73
D	HIS164
D	GLU165
E	TYR107

---

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 E 239

Chain	Residue
E	HIS128
E	LYS132

---

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 602

Chain	Residue
A	TYR80
A	GLN180
A	ASN184
E	ILE70

---

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 810

Chain	Residue
A	THR24
A	GLY26
A	GLU27

---

site_id	CC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE DEQ A 201

Chain	Residue
A	GLN57
A	GLU58
A	TRP61
A	THR89
A	TYR93
A	TYR103
A	TYR107
A	GLU120
B	ASN97
B	THR161
B	PHE162

---

Functional Information from PROSITE/UniProt

site_id	PS01081
Number of Residues	31
Details	HTH_TETR_1 TetR-type HTH domain signature. GYnatTTgeIvklseSSkGnLYyHFkTKen.L

Chain	Residue	Details
B	GLY19-LEU49

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00335","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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