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3BR9

Crystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone Inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-dependent RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-dependent RNA polymerase activity
B0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues24
DetailsBINDING SITE FOR RESIDUE DEY A 579
ChainResidue
APHE193
ASER368
ALEU384
AGLY410
AASN411
AMET414
ATYR415
AGLN446
ATYR448
AGLY449
ASER556
APRO197
AHOH593
AHOH597
AHOH604
AHOH623
AHOH708
ATHR287
ASER288
AASN291
AASN316
AGLY317
AASP318
ACYS366

site_idAC2
Number of Residues25
DetailsBINDING SITE FOR RESIDUE DEY B 579
ChainResidue
BPHE193
BPRO197
BTHR287
BSER288
BASN291
BASN316
BGLY317
BASP318
BCYS366
BSER368
BLEU384
BGLY410
BASN411
BMET414
BTYR415
BGLN446
BILE447
BTYR448
BGLY449
BSER556
BHOH585
BHOH614
BHOH619
BHOH672
BHOH703

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572
ChainResidueDetails
AASP220
AASP318
AASP319
BASP220
BASP318
BASP319

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P26662
ChainResidueDetails
ASER29
ASER42
BSER29
BSER42

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PDB entries from 2024-10-30

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