3BR6

Crystal Structure of the Complex of Rhodamine 6G Bound to QacR(E120Q), a Mutant of a Multidrug Binding Transcriptional Repressor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0045892	biological_process	negative regulation of DNA-templated transcription
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0045892	biological_process	negative regulation of DNA-templated transcription
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0045892	biological_process	negative regulation of DNA-templated transcription
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0045892	biological_process	negative regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 500

Chain	Residue
A	LYS4
A	HIS42
E	LYS17

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 501

Chain	Residue
A	ASN2
A	LEU3
A	LYS4
A	HIS42

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 502

Chain	Residue
A	THR25
A	LYS46

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 503

Chain	Residue
A	THR24
A	GLY26
A	GLU27

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 504

Chain	Residue
A	SER35
A	LYS36
A	GLY37
E	LYS60

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 505

Chain	Residue
E	THR109
E	ASN110
E	SER111

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 506

Chain	Residue
E	THR24
E	THR25
E	GLY26
E	LYS36

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 507

Chain	Residue
D	THR24
D	THR25
D	LYS46

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 508

Chain	Residue
D	TYR20
D	LYS46
D	GLU105
D	TYR106

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 509

Chain	Residue
D	ASN110
D	SER111

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 510

Chain	Residue
B	GLN64
B	GLU90
B	TYR91
D	GLN64
D	GLU90
D	TYR91

---

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 511

Chain	Residue
D	HIS128
D	LYS132
D	ASN146

---

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 512

Chain	Residue
A	HIS128
A	LYS132

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 513

Chain	Residue
E	LYS12
E	ILE56
E	GLU57

---

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 E 514

Chain	Residue
E	LEU3
E	ASN38

---

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 513

Chain	Residue
A	ASP144
A	ASN146
A	ALA147

---

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 515

Chain	Residue
E	LYS36
E	TYR40
E	THR45
E	LYS46
E	GLU47

---

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 513

Chain	Residue
D	PHE162
D	THR163
D	HIS164
D	GLU165
D	GLN166
E	TYR103

---

site_id	CC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE RHQ A 201

Chain	Residue
A	LEU54
A	GLU57
A	GLU58
A	TRP61
A	GLN64
A	THR89
A	TYR93
A	GLN96
A	ILE100
A	TYR123
A	THR161

---

Functional Information from PROSITE/UniProt

site_id	PS01081
Number of Residues	31
Details	HTH_TETR_1 TetR-type HTH domain signature. GYnatTTgeIvklseSSkGnLYyHFkTKen.L

Chain	Residue	Details
B	GLY19-LEU49

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00335

Chain	Residue	Details
B	THR24-PHE43
D	THR24-PHE43
A	THR24-PHE43
E	THR24-PHE43

---