3BR6
Crystal Structure of the Complex of Rhodamine 6G Bound to QacR(E120Q), a Mutant of a Multidrug Binding Transcriptional Repressor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| D | 0003677 | molecular_function | DNA binding |
| D | 0003700 | molecular_function | DNA-binding transcription factor activity |
| D | 0006351 | biological_process | DNA-templated transcription |
| D | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| E | 0003677 | molecular_function | DNA binding |
| E | 0003700 | molecular_function | DNA-binding transcription factor activity |
| E | 0006351 | biological_process | DNA-templated transcription |
| E | 0045892 | biological_process | negative regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 E 500 |
| Chain | Residue |
| A | LYS4 |
| A | HIS42 |
| E | LYS17 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 501 |
| Chain | Residue |
| A | ASN2 |
| A | LEU3 |
| A | LYS4 |
| A | HIS42 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 502 |
| Chain | Residue |
| A | THR25 |
| A | LYS46 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 503 |
| Chain | Residue |
| A | THR24 |
| A | GLY26 |
| A | GLU27 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 504 |
| Chain | Residue |
| A | SER35 |
| A | LYS36 |
| A | GLY37 |
| E | LYS60 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 E 505 |
| Chain | Residue |
| E | THR109 |
| E | ASN110 |
| E | SER111 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 E 506 |
| Chain | Residue |
| E | THR24 |
| E | THR25 |
| E | GLY26 |
| E | LYS36 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 507 |
| Chain | Residue |
| D | THR24 |
| D | THR25 |
| D | LYS46 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 508 |
| Chain | Residue |
| D | TYR20 |
| D | LYS46 |
| D | GLU105 |
| D | TYR106 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 D 509 |
| Chain | Residue |
| D | ASN110 |
| D | SER111 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 510 |
| Chain | Residue |
| B | GLN64 |
| B | GLU90 |
| B | TYR91 |
| D | GLN64 |
| D | GLU90 |
| D | TYR91 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 511 |
| Chain | Residue |
| D | HIS128 |
| D | LYS132 |
| D | ASN146 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 512 |
| Chain | Residue |
| A | HIS128 |
| A | LYS132 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 E 513 |
| Chain | Residue |
| E | LYS12 |
| E | ILE56 |
| E | GLU57 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 E 514 |
| Chain | Residue |
| E | LEU3 |
| E | ASN38 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 513 |
| Chain | Residue |
| A | ASP144 |
| A | ASN146 |
| A | ALA147 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 E 515 |
| Chain | Residue |
| E | LYS36 |
| E | TYR40 |
| E | THR45 |
| E | LYS46 |
| E | GLU47 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 513 |
| Chain | Residue |
| D | PHE162 |
| D | THR163 |
| D | HIS164 |
| D | GLU165 |
| D | GLN166 |
| E | TYR103 |
| site_id | CC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE RHQ A 201 |
| Chain | Residue |
| A | LEU54 |
| A | GLU57 |
| A | GLU58 |
| A | TRP61 |
| A | GLN64 |
| A | THR89 |
| A | TYR93 |
| A | GLN96 |
| A | ILE100 |
| A | TYR123 |
| A | THR161 |
Functional Information from PROSITE/UniProt
| site_id | PS01081 |
| Number of Residues | 31 |
| Details | HTH_TETR_1 TetR-type HTH domain signature. GYnatTTgeIvklseSSkGnLYyHFkTKen.L |
| Chain | Residue | Details |
| B | GLY19-LEU49 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 57 |
| Details | DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00335","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
