Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008234 | molecular_function | cysteine-type peptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 301 |
| Chain | Residue |
| A | LYS20 |
| A | ALA24 |
| A | LYS25 |
| A | LEU26 |
| A | ARG28 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 302 |
| Chain | Residue |
| A | ALA24 |
| A | LYS25 |
| A | ARG150 |
| A | HOH419 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 303 |
| Chain | Residue |
| A | ARG202 |
| B | ARG28 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 301 |
| Chain | Residue |
| A | ARG202 |
| B | LYS20 |
| B | LYS25 |
| B | LEU26 |
| B | ARG28 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 B 302 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR CHAIN C OF LEUPEPTIN |
| Chain | Residue |
| B | GLN45 |
| B | GLY49 |
| B | SER50 |
| B | CYS51 |
| B | TRP52 |
| B | TYR90 |
| B | GLY91 |
| B | GLY92 |
| B | TYR93 |
| B | ASN182 |
| B | HIS183 |
| site_id | AC7 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR CHAIN D OF LEUPEPTIN |
| Chain | Residue |
| A | GLN45 |
| A | GLY49 |
| A | SER50 |
| A | CYS51 |
| A | TRP52 |
| A | TYR90 |
| A | GLY91 |
| A | GLY92 |
| A | TYR93 |
| A | ASP164 |
| A | GLU176 |
| A | ASN182 |
| A | HIS183 |
| A | HOH405 |
| A | HOH408 |
| D | HOH101 |
| D | HOH102 |
| D | HOH103 |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QAlCGSCWAfSS |
| Chain | Residue | Details |
| A | GLN45-SER56 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 34 |
| Details | Motif: {"description":"Nose motif; required for the correct folding of the mature form","evidences":[{"source":"UniProtKB","id":"Q8I6U4","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Motif: {"description":"Arm motif; binds to host hemoglobin and required for the inhibitory interaction between the propeptide and the catalytic domain","evidences":[{"source":"UniProtKB","id":"Q8I6U4","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10088","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10089","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10090","evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | CYS51 | |
| A | HIS183 | |
| A | ASN213 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| B | CYS51 | |
| B | HIS183 | |
| B | ASN213 | |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | HIS183 | |
| A | GLN45 | |
| A | ASN213 | |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| B | HIS183 | |
| B | GLN45 | |
| B | ASN213 | |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | CYS51 | |
| A | HIS183 | |
| A | GLN45 | |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| B | CYS51 | |
| B | HIS183 | |
| B | GLN45 | |
