Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003756 | molecular_function | protein disulfide isomerase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00014 |
| Number of Residues | 4 |
| Details | ER_TARGET Endoplasmic reticulum targeting sequence. HDEL |
| Chain | Residue | Details |
| A | HIS519-LEU522 | |
| site_id | PS00194 |
| Number of Residues | 19 |
| Details | THIOREDOXIN_1 Thioredoxin family active site. LAeFFapWCGHCKnMapeY |
| Chain | Residue | Details |
| A | LEU53-TYR71 | |
| A | LEU398-TYR416 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Nucleophile => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS61 | |
| A | CYS64 | |
| A | CYS406 | |
| A | CYS409 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Contributes to redox potential value => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY62 | |
| A | HIS63 | |
| A | GLY407 | |
| A | HIS408 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Lowers pKa of C-terminal Cys of first active site => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG126 | |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Lowers pKa of C-terminal Cys of second active site => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG471 | |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN82 | |
| A | ASN117 | |
| A | ASN155 | |
| A | ASN174 | |
| A | ASN425 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1mek |
| Chain | Residue | Details |
| A | CYS61 | |
| A | CYS64 | |
| A | GLY62 | |
| A | HIS63 | |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1mek |
| Chain | Residue | Details |
| A | HIS408 | |
| A | CYS406 | |
| A | GLY407 | |
| A | CYS409 | |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1mek |
| Chain | Residue | Details |
| A | CYS61 | |
| A | CYS64 | |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1mek |
| Chain | Residue | Details |
| A | CYS406 | |
| A | CYS409 | |
