3BO7
Crystal structure of Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, 541.m00136
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000209 | biological_process | protein polyubiquitination |
| A | 0000413 | biological_process | protein peptidyl-prolyl isomerization |
| A | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0061630 | molecular_function | ubiquitin protein ligase activity |
| A | 0071013 | cellular_component | catalytic step 2 spliceosome |
| B | 0000209 | biological_process | protein polyubiquitination |
| B | 0000413 | biological_process | protein peptidyl-prolyl isomerization |
| B | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0061630 | molecular_function | ubiquitin protein ligase activity |
| B | 0071013 | cellular_component | catalytic step 2 spliceosome |
| C | 0000209 | biological_process | protein polyubiquitination |
| C | 0000413 | biological_process | protein peptidyl-prolyl isomerization |
| C | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0061630 | molecular_function | ubiquitin protein ligase activity |
| C | 0071013 | cellular_component | catalytic step 2 spliceosome |
| D | 0000209 | biological_process | protein polyubiquitination |
| D | 0000413 | biological_process | protein peptidyl-prolyl isomerization |
| D | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0061630 | molecular_function | ubiquitin protein ligase activity |
| D | 0071013 | cellular_component | catalytic step 2 spliceosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 202 |
| Chain | Residue |
| A | ARG29 |
| A | PHE89 |
| A | GLU90 |
| A | HOH2110 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 203 |
| Chain | Residue |
| D | LYS112 |
| A | LYS112 |
| A | SO4204 |
| A | HOH2111 |
| C | HIS113 |
| C | HOH2106 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 204 |
| Chain | Residue |
| A | LYS112 |
| A | SO4203 |
| A | HOH2112 |
| B | HIS113 |
| D | LYS112 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 205 |
| Chain | Residue |
| A | ARG61 |
| A | GLU63 |
| A | LEU64 |
| A | HOH2113 |
| A | HOH2114 |
| D | SO4203 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 206 |
| Chain | Residue |
| A | ASP155 |
| A | LYS156 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 207 |
| Chain | Residue |
| A | ARG29 |
| A | ARG36 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 202 |
| Chain | Residue |
| B | ARG29 |
| B | PHE89 |
| B | GLU90 |
| B | HOH2123 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 203 |
| Chain | Residue |
| B | GLY101 |
| B | LYS124 |
| B | SER125 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 204 |
| Chain | Residue |
| B | ASN95 |
| B | HOH2124 |
| B | HOH2125 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 205 |
| Chain | Residue |
| B | LYS112 |
| D | HIS113 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 202 |
| Chain | Residue |
| A | HIS113 |
| C | LYS112 |
| C | HOH2106 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 203 |
| Chain | Residue |
| C | ARG29 |
| C | PHE89 |
| C | GLU90 |
| C | HOH2107 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 204 |
| Chain | Residue |
| C | ARG29 |
| C | ARG36 |
| C | PRO84 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 205 |
| Chain | Residue |
| A | ARG10 |
| C | ILE170 |
| C | VAL171 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 206 |
| Chain | Residue |
| C | GLN100 |
| C | GLY101 |
| C | LYS124 |
| C | SER125 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 207 |
| Chain | Residue |
| C | ASN95 |
| C | HOH2077 |
| C | HOH2109 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 208 |
| Chain | Residue |
| A | GLY141 |
| A | GLY142 |
| A | LEU143 |
| A | ASP144 |
| C | EDO209 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO C 209 |
| Chain | Residue |
| A | ASN19 |
| C | SO4208 |
| C | HOH2110 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 202 |
| Chain | Residue |
| D | GLY142 |
| D | LEU143 |
| D | ASP144 |
| site_id | CC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 D 203 |
| Chain | Residue |
| A | LYS157 |
| A | SO4205 |
| D | ARG61 |
| D | GLU63 |
| D | LEU64 |
| D | HOH2119 |
| D | HOH2120 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 204 |
| Chain | Residue |
| D | GLY101 |
| D | LYS124 |
| D | SER125 |
| D | HOH2121 |
| D | HOH2122 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 205 |
| Chain | Residue |
| D | ARG29 |
| D | PHE89 |
| D | GLU90 |
| D | HOH2123 |
| site_id | CC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 206 |
| Chain | Residue |
| D | ARG29 |
| D | ARG36 |
| D | PRO84 |
| site_id | CC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 D 207 |
| Chain | Residue |
| D | ARG138 |
| site_id | CC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO D 208 |
| Chain | Residue |
| D | ASN19 |
| site_id | CC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO D 209 |
| Chain | Residue |
| D | THR154 |
| site_id | CC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO D 210 |
| Chain | Residue |
| D | PRO28 |
| D | ARG29 |
| D | ASP32 |
| D | PHE83 |
| D | PHE176 |
| site_id | DC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO D 211 |
| Chain | Residue |
| H | SAR7 |
| H | VAL9 |
| D | HIS49 |
| D | ARG50 |
| D | GLN58 |
| H | BMT5 |
| site_id | DC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO G 12 |
| Chain | Residue |
| G | DAL1 |
| G | MLE2 |
| site_id | DC3 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR CHAIN E OF CYCLOSPORIN A |
| Chain | Residue |
| A | ARG50 |
| A | PHE55 |
| A | GLN58 |
| A | ALA108 |
| A | ASN109 |
| A | ASP110 |
| A | GLU118 |
| A | PHE120 |
| A | HIS128 |
| A | LEU129 |
| A | HIS133 |
| D | ARG61 |
| D | ARG78 |
| D | ASP110 |
| D | SER114 |
| D | HOH2043 |
| E | HOH2002 |
| E | HOH2003 |
| E | HOH2004 |
| H | ABA6 |
| H | SAR7 |
| H | MLE8 |
| site_id | DC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR CHAIN F OF CYCLOSPORIN A |
| Chain | Residue |
| B | ARG50 |
| B | PHE55 |
| B | MET56 |
| B | GLN58 |
| B | ALA108 |
| B | ASN109 |
| B | ASP110 |
| B | PHE120 |
| B | HIS128 |
| B | LEU129 |
| B | HIS133 |
| D | ASN95 |
| F | HOH2001 |
| F | HOH2002 |
| site_id | DC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR CHAIN G OF CYCLOSPORIN A |
| Chain | Residue |
| C | ARG50 |
| C | PHE55 |
| C | GLN58 |
| C | ARG61 |
| C | ALA108 |
| C | ASN109 |
| C | ASP110 |
| C | GLU118 |
| C | PHE120 |
| C | HIS128 |
| C | LEU129 |
| C | HIS133 |
| G | EDO12 |
| site_id | DC6 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR CHAIN H OF CYCLOSPORIN A |
| Chain | Residue |
| A | ARG61 |
| A | ARG78 |
| A | ASP110 |
| A | SER114 |
| B | ASN95 |
| D | ARG50 |
| D | PHE55 |
| D | MET56 |
| D | GLN58 |
| D | ALA108 |
| D | ASN109 |
| D | ASP110 |
| D | PHE120 |
| D | HIS128 |
| D | HIS133 |
| D | EDO211 |
| E | ABA6 |
| E | SAR7 |
| E | MLE8 |
| H | HOH2002 |
| H | HOH2003 |
| H | HOH2005 |
