3BNM

Crystal structure of polyamine oxidase FMS1 from Saccharomyces cerevisiae in complex with bis-(3R,3'R)-methylated spermine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0003682	molecular_function	chromatin binding
A	0005737	cellular_component	cytoplasm
A	0015940	biological_process	pantothenate biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0046208	biological_process	spermine catabolic process
A	0046592	molecular_function	polyamine oxidase activity
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0052897	molecular_function	N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity
A	0052901	molecular_function	spermine:oxygen oxidoreductase (spermidine-forming) activity
A	0052902	molecular_function	spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity
A	0052903	molecular_function	N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
A	0052904	molecular_function	N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0003682	molecular_function	chromatin binding
B	0005737	cellular_component	cytoplasm
B	0015940	biological_process	pantothenate biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046208	biological_process	spermine catabolic process
B	0046592	molecular_function	polyamine oxidase activity
B	0050660	molecular_function	flavin adenine dinucleotide binding
B	0052897	molecular_function	N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity
B	0052901	molecular_function	spermine:oxygen oxidoreductase (spermidine-forming) activity
B	0052902	molecular_function	spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity
B	0052903	molecular_function	N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
B	0052904	molecular_function	N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	33
Details	BINDING SITE FOR RESIDUE FAD B 802

Chain	Residue
B	GLY15
B	ARG47
B	GLY62
B	ALA63
B	SER64
B	TRP65
B	HIS67
B	CYS221
B	VAL223
B	THR252
B	VAL253
B	GLY17
B	GLY270
B	LEU294
B	ALA449
B	TYR450
B	GLY478
B	GLU479
B	GLY487
B	CYS488
B	ALA489
B	ALA492
B	ILE18
B	SPJ803
B	HOH805
B	HOH809
B	HOH886
B	ALA19
B	LEU38
B	GLU39
B	ALA40
B	ARG41
B	GLY46

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site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SPJ B 803

Chain	Residue
B	TRP65
B	HIS67
B	ASP68
B	TRP174
B	GLY190
B	TYR450
B	GLY485
B	ALA486
B	CYS488
B	TYR490
B	FAD802

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site_id	AC3
Number of Residues	35
Details	BINDING SITE FOR RESIDUE FAD A 801

Chain	Residue
A	GLY15
A	GLY17
A	ILE18
A	ALA19
A	GLU39
A	ALA40
A	ARG41
A	GLY46
A	ARG47
A	GLY62
A	ALA63
A	SER64
A	TRP65
A	HIS67
A	VAL223
A	THR252
A	VAL253
A	GLY270
A	LEU294
A	TYR445
A	ALA449
A	TYR450
A	GLY478
A	GLU479
A	GLY487
A	CYS488
A	ALA489
A	ALA492
A	SPJ802
A	HOH803
A	HOH805
A	HOH808
A	HOH830
A	HOH839
A	HOH849

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site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SPJ A 802

Chain	Residue
A	TRP65
A	HIS67
A	LEU173
A	TRP174
A	ASN195
A	LEU375
A	TYR450
A	ALA486
A	GLY487
A	CYS488
A	FAD801

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