Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3BLX

Yeast Isocitrate Dehydrogenase (Apo Form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006099	biological_process	tricarboxylic acid cycle
A	0006102	biological_process	isocitrate metabolic process
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0042645	cellular_component	mitochondrial nucleoid
A	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
A	0051287	molecular_function	NAD binding
A	0097054	biological_process	L-glutamate biosynthetic process
B	0000287	molecular_function	magnesium ion binding
B	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006099	biological_process	tricarboxylic acid cycle
B	0006102	biological_process	isocitrate metabolic process
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
B	0051287	molecular_function	NAD binding
B	0097054	biological_process	L-glutamate biosynthetic process
C	0000287	molecular_function	magnesium ion binding
C	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005758	cellular_component	mitochondrial intermembrane space
C	0005759	cellular_component	mitochondrial matrix
C	0005829	cellular_component	cytosol
C	0006099	biological_process	tricarboxylic acid cycle
C	0006102	biological_process	isocitrate metabolic process
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0042645	cellular_component	mitochondrial nucleoid
C	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
C	0051287	molecular_function	NAD binding
C	0097054	biological_process	L-glutamate biosynthetic process
D	0000287	molecular_function	magnesium ion binding
D	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006099	biological_process	tricarboxylic acid cycle
D	0006102	biological_process	isocitrate metabolic process
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
D	0051287	molecular_function	NAD binding
D	0097054	biological_process	L-glutamate biosynthetic process
E	0000287	molecular_function	magnesium ion binding
E	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
E	0005515	molecular_function	protein binding
E	0005739	cellular_component	mitochondrion
E	0005758	cellular_component	mitochondrial intermembrane space
E	0005759	cellular_component	mitochondrial matrix
E	0005829	cellular_component	cytosol
E	0006099	biological_process	tricarboxylic acid cycle
E	0006102	biological_process	isocitrate metabolic process
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0042645	cellular_component	mitochondrial nucleoid
E	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
E	0051287	molecular_function	NAD binding
E	0097054	biological_process	L-glutamate biosynthetic process
F	0000287	molecular_function	magnesium ion binding
F	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0006099	biological_process	tricarboxylic acid cycle
F	0006102	biological_process	isocitrate metabolic process
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
F	0051287	molecular_function	NAD binding
F	0097054	biological_process	L-glutamate biosynthetic process
G	0000287	molecular_function	magnesium ion binding
G	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
G	0005515	molecular_function	protein binding
G	0005739	cellular_component	mitochondrion
G	0005758	cellular_component	mitochondrial intermembrane space
G	0005759	cellular_component	mitochondrial matrix
G	0005829	cellular_component	cytosol
G	0006099	biological_process	tricarboxylic acid cycle
G	0006102	biological_process	isocitrate metabolic process
G	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G	0042645	cellular_component	mitochondrial nucleoid
G	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
G	0051287	molecular_function	NAD binding
G	0097054	biological_process	L-glutamate biosynthetic process
H	0000287	molecular_function	magnesium ion binding
H	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
H	0005515	molecular_function	protein binding
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0006099	biological_process	tricarboxylic acid cycle
H	0006102	biological_process	isocitrate metabolic process
H	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
H	0051287	molecular_function	NAD binding
H	0097054	biological_process	L-glutamate biosynthetic process
I	0000287	molecular_function	magnesium ion binding
I	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
I	0005515	molecular_function	protein binding
I	0005739	cellular_component	mitochondrion
I	0005758	cellular_component	mitochondrial intermembrane space
I	0005759	cellular_component	mitochondrial matrix
I	0005829	cellular_component	cytosol
I	0006099	biological_process	tricarboxylic acid cycle
I	0006102	biological_process	isocitrate metabolic process
I	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
I	0042645	cellular_component	mitochondrial nucleoid
I	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
I	0051287	molecular_function	NAD binding
I	0097054	biological_process	L-glutamate biosynthetic process
J	0000287	molecular_function	magnesium ion binding
J	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
J	0005515	molecular_function	protein binding
J	0005739	cellular_component	mitochondrion
J	0005759	cellular_component	mitochondrial matrix
J	0006099	biological_process	tricarboxylic acid cycle
J	0006102	biological_process	isocitrate metabolic process
J	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
J	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
J	0051287	molecular_function	NAD binding
J	0097054	biological_process	L-glutamate biosynthetic process
K	0000287	molecular_function	magnesium ion binding
K	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
K	0005515	molecular_function	protein binding
K	0005739	cellular_component	mitochondrion
K	0005758	cellular_component	mitochondrial intermembrane space
K	0005759	cellular_component	mitochondrial matrix
K	0005829	cellular_component	cytosol
K	0006099	biological_process	tricarboxylic acid cycle
K	0006102	biological_process	isocitrate metabolic process
K	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
K	0042645	cellular_component	mitochondrial nucleoid
K	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
K	0051287	molecular_function	NAD binding
K	0097054	biological_process	L-glutamate biosynthetic process
L	0000287	molecular_function	magnesium ion binding
L	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
L	0005515	molecular_function	protein binding
L	0005739	cellular_component	mitochondrion
L	0005759	cellular_component	mitochondrial matrix
L	0006099	biological_process	tricarboxylic acid cycle
L	0006102	biological_process	isocitrate metabolic process
L	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
L	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
L	0051287	molecular_function	NAD binding
L	0097054	biological_process	L-glutamate biosynthetic process
M	0000287	molecular_function	magnesium ion binding
M	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
M	0005515	molecular_function	protein binding
M	0005739	cellular_component	mitochondrion
M	0005758	cellular_component	mitochondrial intermembrane space
M	0005759	cellular_component	mitochondrial matrix
M	0005829	cellular_component	cytosol
M	0006099	biological_process	tricarboxylic acid cycle
M	0006102	biological_process	isocitrate metabolic process
M	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
M	0042645	cellular_component	mitochondrial nucleoid
M	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
M	0051287	molecular_function	NAD binding
M	0097054	biological_process	L-glutamate biosynthetic process
N	0000287	molecular_function	magnesium ion binding
N	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
N	0005515	molecular_function	protein binding
N	0005739	cellular_component	mitochondrion
N	0005759	cellular_component	mitochondrial matrix
N	0006099	biological_process	tricarboxylic acid cycle
N	0006102	biological_process	isocitrate metabolic process
N	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
N	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
N	0051287	molecular_function	NAD binding
N	0097054	biological_process	L-glutamate biosynthetic process
O	0000287	molecular_function	magnesium ion binding
O	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
O	0005515	molecular_function	protein binding
O	0005739	cellular_component	mitochondrion
O	0005758	cellular_component	mitochondrial intermembrane space
O	0005759	cellular_component	mitochondrial matrix
O	0005829	cellular_component	cytosol
O	0006099	biological_process	tricarboxylic acid cycle
O	0006102	biological_process	isocitrate metabolic process
O	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
O	0042645	cellular_component	mitochondrial nucleoid
O	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
O	0051287	molecular_function	NAD binding
O	0097054	biological_process	L-glutamate biosynthetic process
P	0000287	molecular_function	magnesium ion binding
P	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
P	0005515	molecular_function	protein binding
P	0005739	cellular_component	mitochondrion
P	0005759	cellular_component	mitochondrial matrix
P	0006099	biological_process	tricarboxylic acid cycle
P	0006102	biological_process	isocitrate metabolic process
P	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
P	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
P	0051287	molecular_function	NAD binding
P	0097054	biological_process	L-glutamate biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00470
Number of Residues	20
Details	IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. SMYGTIlGNigAali.GGPGL

Chain	Residue	Details
A	SER237-LEU256
B	ASN244-LEU264

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	56
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	24
Details	Site: {"description":"Critical for catalysis","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P50213","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	8
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17761666","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
B	TYR142

site_id	CSA10
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
C	PHE136

site_id	CSA11
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
E	PHE136

site_id	CSA12
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
G	PHE136

site_id	CSA13
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
I	PHE136

site_id	CSA14
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
K	PHE136

site_id	CSA15
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
M	PHE136

site_id	CSA16
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
O	PHE136

site_id	CSA17
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
B	LYS189
B	ASP222

site_id	CSA18
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
D	LYS189
D	ASP222

site_id	CSA19
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
F	LYS189
F	ASP222

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
D	TYR142

site_id	CSA20
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
H	LYS189
H	ASP222

site_id	CSA21
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
J	LYS189
J	ASP222

site_id	CSA22
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
L	LYS189
L	ASP222

site_id	CSA23
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
N	LYS189
N	ASP222

site_id	CSA24
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
P	LYS189
P	ASP222

site_id	CSA25
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
A	LYS183
A	ASP217

site_id	CSA26
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
C	LYS183
C	ASP217

site_id	CSA27
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
E	LYS183
E	ASP217

site_id	CSA28
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
G	LYS183
G	ASP217

site_id	CSA29
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
I	LYS183
I	ASP217

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
F	TYR142

site_id	CSA30
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
K	LYS183
K	ASP217

site_id	CSA31
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
M	LYS183
M	ASP217

site_id	CSA32
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
O	LYS183
O	ASP217

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
H	TYR142

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
J	TYR142

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
L	TYR142

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
N	TYR142

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
P	TYR142

site_id	CSA9
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
A	PHE136

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)