3BLV

Yeast Isocitrate Dehydrogenase with Citrate Bound in the Regulatory Subunits

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003723	molecular_function	RNA binding
A	0003824	molecular_function	catalytic activity
A	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006099	biological_process	tricarboxylic acid cycle
A	0006102	biological_process	isocitrate metabolic process
A	0006537	biological_process	glutamate biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0042645	cellular_component	mitochondrial nucleoid
A	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
A	0046872	molecular_function	metal ion binding
A	0051287	molecular_function	NAD binding
B	0000287	molecular_function	magnesium ion binding
B	0003723	molecular_function	RNA binding
B	0003824	molecular_function	catalytic activity
B	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006099	biological_process	tricarboxylic acid cycle
B	0006102	biological_process	isocitrate metabolic process
B	0006537	biological_process	glutamate biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
B	0046872	molecular_function	metal ion binding
B	0051287	molecular_function	NAD binding
C	0000287	molecular_function	magnesium ion binding
C	0003723	molecular_function	RNA binding
C	0003824	molecular_function	catalytic activity
C	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005758	cellular_component	mitochondrial intermembrane space
C	0005759	cellular_component	mitochondrial matrix
C	0005829	cellular_component	cytosol
C	0006099	biological_process	tricarboxylic acid cycle
C	0006102	biological_process	isocitrate metabolic process
C	0006537	biological_process	glutamate biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0042645	cellular_component	mitochondrial nucleoid
C	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
C	0046872	molecular_function	metal ion binding
C	0051287	molecular_function	NAD binding
D	0000287	molecular_function	magnesium ion binding
D	0003723	molecular_function	RNA binding
D	0003824	molecular_function	catalytic activity
D	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
D	0005515	molecular_function	protein binding
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006099	biological_process	tricarboxylic acid cycle
D	0006102	biological_process	isocitrate metabolic process
D	0006537	biological_process	glutamate biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
D	0046872	molecular_function	metal ion binding
D	0051287	molecular_function	NAD binding
E	0000287	molecular_function	magnesium ion binding
E	0003723	molecular_function	RNA binding
E	0003824	molecular_function	catalytic activity
E	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
E	0005515	molecular_function	protein binding
E	0005739	cellular_component	mitochondrion
E	0005758	cellular_component	mitochondrial intermembrane space
E	0005759	cellular_component	mitochondrial matrix
E	0005829	cellular_component	cytosol
E	0006099	biological_process	tricarboxylic acid cycle
E	0006102	biological_process	isocitrate metabolic process
E	0006537	biological_process	glutamate biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0042645	cellular_component	mitochondrial nucleoid
E	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
E	0046872	molecular_function	metal ion binding
E	0051287	molecular_function	NAD binding
F	0000287	molecular_function	magnesium ion binding
F	0003723	molecular_function	RNA binding
F	0003824	molecular_function	catalytic activity
F	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
F	0005515	molecular_function	protein binding
F	0005739	cellular_component	mitochondrion
F	0005759	cellular_component	mitochondrial matrix
F	0006099	biological_process	tricarboxylic acid cycle
F	0006102	biological_process	isocitrate metabolic process
F	0006537	biological_process	glutamate biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
F	0046872	molecular_function	metal ion binding
F	0051287	molecular_function	NAD binding
G	0000287	molecular_function	magnesium ion binding
G	0003723	molecular_function	RNA binding
G	0003824	molecular_function	catalytic activity
G	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
G	0005515	molecular_function	protein binding
G	0005739	cellular_component	mitochondrion
G	0005758	cellular_component	mitochondrial intermembrane space
G	0005759	cellular_component	mitochondrial matrix
G	0005829	cellular_component	cytosol
G	0006099	biological_process	tricarboxylic acid cycle
G	0006102	biological_process	isocitrate metabolic process
G	0006537	biological_process	glutamate biosynthetic process
G	0016491	molecular_function	oxidoreductase activity
G	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G	0042645	cellular_component	mitochondrial nucleoid
G	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
G	0046872	molecular_function	metal ion binding
G	0051287	molecular_function	NAD binding
H	0000287	molecular_function	magnesium ion binding
H	0003723	molecular_function	RNA binding
H	0003824	molecular_function	catalytic activity
H	0004449	molecular_function	isocitrate dehydrogenase (NAD+) activity
H	0005515	molecular_function	protein binding
H	0005739	cellular_component	mitochondrion
H	0005759	cellular_component	mitochondrial matrix
H	0006099	biological_process	tricarboxylic acid cycle
H	0006102	biological_process	isocitrate metabolic process
H	0006537	biological_process	glutamate biosynthetic process
H	0016491	molecular_function	oxidoreductase activity
H	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H	0045242	cellular_component	isocitrate dehydrogenase complex (NAD+)
H	0046872	molecular_function	metal ion binding
H	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FLC A 1001

Chain	Residue
A	THR83
A	SER92
A	ASN94
A	ARG98
A	ARG129
A	PHE136
A	THR241
A	ARG274
B	LYS189

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FLC C 1002

Chain	Residue
C	THR83
C	SER92
C	VAL95
C	ARG98
C	ARG129
C	PHE136
C	THR241
C	ARG274
D	LYS189

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FLC E 1003

Chain	Residue
E	THR83
E	SER92
E	ASN94
E	ARG98
E	ARG129
E	PHE136
E	THR241
E	ARG274
F	LYS189

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE FLC G 1004

Chain	Residue
G	THR83
G	SER92
G	ASN94
G	ARG98
G	ARG129
G	PHE136
G	THR241
G	ARG274
H	LYS189
H	THR191

---

Functional Information from PROSITE/UniProt

site_id	PS00470
Number of Residues	21
Details	IDH_IMDH Isocitrate and isopropylmalate dehydrogenases signature. NLYGDIlSDlnSglsaGSLGL

Chain	Residue	Details
B	ASN244-LEU264
A	SER237-LEU256

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Site: {"description":"Critical for catalysis","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P50213","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17761666","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
B	TYR142

---

site_id	CSA10
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
D	LYS189
D	ASP222

---

site_id	CSA11
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
F	LYS189
F	ASP222

---

site_id	CSA12
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
H	LYS189
H	ASP222

---

site_id	CSA13
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
A	LYS183
A	ASP217

---

site_id	CSA14
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
C	LYS183
C	ASP217

---

site_id	CSA15
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
E	LYS183
E	ASP217

---

site_id	CSA16
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
G	LYS183
G	ASP217

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
D	TYR142

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
F	TYR142

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
H	TYR142

---

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
A	PHE136

---

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
C	PHE136

---

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
E	PHE136

---

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
G	PHE136

---

site_id	CSA9
Number of Residues	2
Details	Annotated By Reference To The Literature 1a05

Chain	Residue	Details
B	LYS189
B	ASP222

---