3BKB

Crystal structure of human Feline Sarcoma Viral Oncogene Homologue (v-FES)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 1

Chain	Residue
A	ARG579
A	ARG579
A	ARG579
A	ARG581
A	ARG581
A	ARG581
A	HOH964
A	HOH964
A	HOH964

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 2

Chain	Residue
A	EDO8
A	ARG467
A	ARG483
A	SER485

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A 3

Chain	Residue
A	LYS603
A	ARG682
A	ARG706
A	TYR713
A	ALA715
A	SER716
A	LEU719
A	HOH1113
A	HOH1178

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 823

Chain	Residue
A	ARG609
A	LYS612

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 824

Chain	Residue
A	VAL724
A	THR727
A	PRO729
A	TRP744
A	THR769
A	HOH840

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE EDO A 825

Chain	Residue
A	ASP683
A	ALA685
A	ARG687
A	ASN688
A	PRO723
A	TRP726
A	HOH832
A	HOH849
A	HOH899
A	HOH982

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 4

Chain	Residue
A	GLU518
A	ARG649
A	SER759
A	HOH880
A	HOH1105
A	HOH1148

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 5

Chain	Residue
A	HIS558
A	LEU561
A	TYR633
A	HOH1097
A	HOH1189

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 6

Chain	Residue
A	ASP510
A	TRP751
A	HOH1002
A	HOH1112
A	HOH1204

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 7

Chain	Residue
A	GLN640
A	HOH1055

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 8

Chain	Residue
A	SO42
A	ARG467
A	SER485
A	VAL492
A	HIS503

---

site_id	BC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE STU A 826

Chain	Residue
A	ILE567
A	GLY568
A	ARG569
A	ALA588
A	GLU607
A	GLU637
A	LEU638
A	VAL639
A	GLY642
A	ARG687
A	LEU690
A	SER700
A	ASP701
A	HOH1183

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGNFGEVFsGrlradntl..........VAVK

Chain	Residue	Details
A	ILE567-LYS590

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNCLV

Chain	Residue	Details
A	CYS679-VAL691

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP683

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ILE567
A	LYS590

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:15485904, ECO:0000269|PubMed:18046454, ECO:0000269|PubMed:18775312, ECO:0000269|PubMed:19382747, ECO:0000269|PubMed:7687763, ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	TYR713

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	SER716

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ARG687
A	ASP683

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP683
A	ALA685

---

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP683
A	ALA685
A	ASN688

---