3BJ8

Spermine/spermidine N1-acetyltransferase from mouse: Crystal structure of a ternary complex reveals solvent-mediated spermine binding

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001525	biological_process	angiogenesis
A	0004145	molecular_function	diamine N-acetyltransferase activity
A	0005829	cellular_component	cytosol
A	0006595	biological_process	polyamine metabolic process
A	0006596	biological_process	polyamine biosynthetic process
A	0006598	biological_process	polyamine catabolic process
A	0008080	molecular_function	N-acetyltransferase activity
A	0009447	biological_process	putrescine catabolic process
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0019809	molecular_function	spermidine binding
A	0032918	biological_process	spermidine acetylation
A	0042127	biological_process	regulation of cell population proliferation
A	0042802	molecular_function	identical protein binding
A	0046208	biological_process	spermine catabolic process
B	0001525	biological_process	angiogenesis
B	0004145	molecular_function	diamine N-acetyltransferase activity
B	0005829	cellular_component	cytosol
B	0006595	biological_process	polyamine metabolic process
B	0006596	biological_process	polyamine biosynthetic process
B	0006598	biological_process	polyamine catabolic process
B	0008080	molecular_function	N-acetyltransferase activity
B	0009447	biological_process	putrescine catabolic process
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0019809	molecular_function	spermidine binding
B	0032918	biological_process	spermidine acetylation
B	0042127	biological_process	regulation of cell population proliferation
B	0042802	molecular_function	identical protein binding
B	0046208	biological_process	spermine catabolic process
C	0001525	biological_process	angiogenesis
C	0004145	molecular_function	diamine N-acetyltransferase activity
C	0005829	cellular_component	cytosol
C	0006595	biological_process	polyamine metabolic process
C	0006596	biological_process	polyamine biosynthetic process
C	0006598	biological_process	polyamine catabolic process
C	0008080	molecular_function	N-acetyltransferase activity
C	0009447	biological_process	putrescine catabolic process
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0019809	molecular_function	spermidine binding
C	0032918	biological_process	spermidine acetylation
C	0042127	biological_process	regulation of cell population proliferation
C	0042802	molecular_function	identical protein binding
C	0046208	biological_process	spermine catabolic process
D	0001525	biological_process	angiogenesis
D	0004145	molecular_function	diamine N-acetyltransferase activity
D	0005829	cellular_component	cytosol
D	0006595	biological_process	polyamine metabolic process
D	0006596	biological_process	polyamine biosynthetic process
D	0006598	biological_process	polyamine catabolic process
D	0008080	molecular_function	N-acetyltransferase activity
D	0009447	biological_process	putrescine catabolic process
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
D	0019809	molecular_function	spermidine binding
D	0032918	biological_process	spermidine acetylation
D	0042127	biological_process	regulation of cell population proliferation
D	0042802	molecular_function	identical protein binding
D	0046208	biological_process	spermine catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SPM C 500

Chain	Residue
C	ASP93
C	LEU128
D	ASP82
D	HIS126

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE COA A 400

Chain	Residue
A	GLY104
A	GLY106
A	SER107
A	PHE139
A	ARG142
A	ARG143
A	PHE94
A	PHE95
A	ARG101
A	GLY102
A	PHE103

---

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE COA B 401

Chain	Residue
B	PHE94
B	ARG101
B	GLY102
B	PHE103
B	GLY104
B	GLY106
B	SER107
B	PRO135
B	PHE139
B	ARG142
B	ARG143
C	PRO135
C	ASN138
C	PHE139

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE COA C 402

Chain	Residue
B	SER98
B	ARG101
C	ARG101
C	GLY102
C	PHE103
C	GLY104
C	GLY106
C	SER107
C	PRO135
C	PHE139
C	ARG143

---

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE COA D 403

Chain	Residue
A	TYR27
A	SER98
D	TYR27
D	PHE94
D	PHE95
D	ARG101
D	GLY102
D	PHE103
D	GLY104
D	GLY106
D	SER107
D	PHE139
D	ARG142
D	ARG143

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P0A951","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P21673","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	64
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18690703","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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