3BI5

Crystal structures of fms1 in complex with its inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003682	molecular_function	chromatin binding
A	0005737	cellular_component	cytoplasm
A	0006338	biological_process	chromatin remodeling
A	0015940	biological_process	pantothenate biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0046208	biological_process	spermine catabolic process
A	0046592	molecular_function	polyamine oxidase activity
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0052897	molecular_function	N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity
A	0052901	molecular_function	spermine:oxygen oxidoreductase (spermidine-forming) activity
A	0052902	molecular_function	spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity
A	0052903	molecular_function	N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
A	0052904	molecular_function	N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
B	0003682	molecular_function	chromatin binding
B	0005737	cellular_component	cytoplasm
B	0006338	biological_process	chromatin remodeling
B	0015940	biological_process	pantothenate biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0046208	biological_process	spermine catabolic process
B	0046592	molecular_function	polyamine oxidase activity
B	0050660	molecular_function	flavin adenine dinucleotide binding
B	0052897	molecular_function	N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity
B	0052901	molecular_function	spermine:oxygen oxidoreductase (spermidine-forming) activity
B	0052902	molecular_function	spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity
B	0052903	molecular_function	N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity
B	0052904	molecular_function	N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	32
Details	BINDING SITE FOR RESIDUE FAD A 801

Chain	Residue
A	ILE14
A	ARG47
A	GLY62
A	ALA63
A	SER64
A	TRP65
A	HIS67
A	VAL223
A	THR252
A	VAL253
A	GLY270
A	GLY15
A	ALA449
A	TYR450
A	GLY478
A	GLU479
A	GLY487
A	CYS488
A	ALA489
A	ALA492
A	DIA2841
A	HOH2842
A	GLY17
A	HOH2848
A	HOH2852
A	HOH2855
A	ILE18
A	ALA19
A	GLU39
A	ALA40
A	ARG41
A	GLY46

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DIA A 2841

Chain	Residue
A	HIS67
A	PHE97
A	LEU173
A	TRP174
A	PHE359
A	TYR450
A	FAD801

---

site_id	AC3
Number of Residues	27
Details	BINDING SITE FOR RESIDUE FAD B 802

Chain	Residue
B	GLY15
B	ILE18
B	ALA19
B	GLU39
B	ALA40
B	ARG41
B	GLY46
B	ARG47
B	GLY62
B	ALA63
B	SER64
B	TRP65
B	HIS67
B	VAL223
B	THR252
B	VAL253
B	GLY270
B	ALA449
B	TYR450
B	GLY478
B	GLU479
B	GLY487
B	CYS488
B	ALA489
B	ALA492
B	DIA2842
B	HOH2847

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DIA B 2842

Chain	Residue
B	HIS67
B	LEU173
B	TRP174
B	PHE359
B	TYR450
B	GLY487
B	CYS488
B	FAD802

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1f8r

Chain	Residue	Details
A	GLY193
A	LYS296

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1f8r

Chain	Residue	Details
B	GLY193
B	LYS296

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1f8r

Chain	Residue	Details
A	HIS67

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1f8r

Chain	Residue	Details
B	HIS67

---