3BHJ
Crystal structure of human Carbonyl Reductase 1 in complex with glutathione
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004090 | molecular_function | carbonyl reductase (NADPH) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0008211 | biological_process | glucocorticoid metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0016655 | molecular_function | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor |
| A | 0019371 | biological_process | cyclooxygenase pathway |
| A | 0030855 | biological_process | epithelial cell differentiation |
| A | 0042373 | biological_process | vitamin K metabolic process |
| A | 0047020 | molecular_function | 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity |
| A | 0047021 | molecular_function | 15-hydroxyprostaglandin dehydrogenase (NADP+) activity |
| A | 0050221 | molecular_function | prostaglandin E2 9-reductase activity |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0160163 | molecular_function | S-nitrosoglutathione reductase (NADPH) activity |
| A | 1903561 | cellular_component | extracellular vesicle |
| A | 2000379 | biological_process | positive regulation of reactive oxygen species metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 310 |
| Chain | Residue |
| A | ASP64 |
| A | THR163 |
| A | ARG209 |
| A | HOH380 |
| A | HOH387 |
| A | HOH471 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 311 |
| Chain | Residue |
| A | LYS219 |
| A | HOH327 |
| A | HOH371 |
| A | LYS216 |
| A | GLY217 |
| A | ASP218 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 313 |
| Chain | Residue |
| A | ARG57 |
| A | PHE58 |
| A | HOH476 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 314 |
| Chain | Residue |
| A | LYS14 |
| A | GLY15 |
| A | HOH331 |
| A | HOH358 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 319 |
| Chain | Residue |
| A | SER2 |
| A | GLY3 |
| A | GLN47 |
| A | GLN50 |
| A | LYS129 |
| A | HOH522 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 320 |
| Chain | Residue |
| A | ARG41 |
| A | ARG118 |
| A | HOH402 |
| A | HOH451 |
| A | HOH459 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE AB3 A 307 |
| Chain | Residue |
| A | SER139 |
| A | ILE140 |
| A | MET141 |
| A | TYR193 |
| A | GLY228 |
| A | TRP229 |
| A | HOH394 |
| A | HOH423 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE AB3 A 308 |
| Chain | Residue |
| A | ARG22 |
| A | ARG26 |
| A | ILE140 |
| A | ARG144 |
| A | GLU244 |
| A | HOH490 |
| A | HOH555 |
| site_id | AC9 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE NAP A 309 |
| Chain | Residue |
| A | GLY11 |
| A | ASN13 |
| A | LYS14 |
| A | GLY15 |
| A | ILE16 |
| A | ARG37 |
| A | LEU61 |
| A | ASP62 |
| A | ILE63 |
| A | ASP64 |
| A | ASN89 |
| A | ALA90 |
| A | GLY91 |
| A | ILE92 |
| A | SER138 |
| A | TYR193 |
| A | LYS197 |
| A | PRO227 |
| A | GLY228 |
| A | TRP229 |
| A | THR232 |
| A | ASP233 |
| A | MET234 |
| A | ALA235 |
| A | HOH322 |
| A | HOH323 |
| A | HOH331 |
| A | HOH334 |
| A | HOH338 |
| A | HOH345 |
| A | HOH360 |
| A | HOH404 |
| A | HOH427 |
| A | HOH545 |
| A | HOH546 |
| site_id | BC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE GSH A 315 |
| Chain | Residue |
| A | PHE94 |
| A | LYS95 |
| A | PHE102 |
| A | GLN105 |
| A | SER191 |
| A | ALA192 |
| A | TYR193 |
| A | MET234 |
| A | HOH340 |
| A | HOH367 |
| A | HOH406 |
| A | HOH435 |
| A | HOH470 |
| A | HOH492 |
| A | HOH518 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE P33 A 316 |
| Chain | Residue |
| A | LYS210 |
| A | GLN214 |
| A | HOH487 |
| A | HOH488 |
| A | HOH533 |
| A | ALA93 |
| A | THR122 |
| A | LEU125 |
| A | HIS207 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE P33 A 317 |
| Chain | Residue |
| A | GLN60 |
| A | SER68 |
| A | LYS156 |
| A | GLU166 |
| A | LEU170 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 318 |
| Chain | Residue |
| A | CYS25 |
| A | ARG26 |
| A | PHE28 |
| A | SER29 |
| A | GLN184 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. KgvhqkegwpSsaYGVTKIGVtVLSrIHA |
| Chain | Residue | Details |
| A | LYS180-ALA208 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | TYR193 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15799708, ECO:0000269|PubMed:17912391, ECO:0000269|PubMed:18826943 |
| Chain | Residue | Details |
| A | VAL9 | |
| A | ASP62 | |
| A | ASN89 | |
| A | TYR193 | |
| A | VAL230 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | PHE94 | |
| A | GLN105 | |
| A | SER139 | |
| A | ALA192 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P47727 |
| Chain | Residue | Details |
| A | SER1 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P48758 |
| Chain | Residue | Details |
| A | SER29 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-1-carboxyethyl lysine => ECO:0000269|PubMed:8421682 |
| Chain | Residue | Details |
| A | LYS238 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| A | GLU152 | |
| A | TYR193 | |
| A | SER139 | |
| A | LYS197 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| A | ASN113 | |
| A | TYR193 | |
| A | SER139 | |
| A | LYS197 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| A | LYS197 | |
| A | SER190 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1db3 |
| Chain | Residue | Details |
| A | TYR193 | |
| A | LYS197 |
