3BH3

Crystal structure of acetoacetate decarboxylase from Chromobacterium violaceum in complex with acetyl acetone Schiff base intermediate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016829	molecular_function	lyase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0047602	molecular_function	acetoacetate decarboxylase activity
B	0016829	molecular_function	lyase activity
B	0016831	molecular_function	carboxy-lyase activity
B	0047602	molecular_function	acetoacetate decarboxylase activity
C	0016829	molecular_function	lyase activity
C	0016831	molecular_function	carboxy-lyase activity
C	0047602	molecular_function	acetoacetate decarboxylase activity
D	0016829	molecular_function	lyase activity
D	0016831	molecular_function	carboxy-lyase activity
D	0047602	molecular_function	acetoacetate decarboxylase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PNH A 247

Chain	Residue
A	ARG30
A	TYR75
A	LYS116

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PNH B 247

Chain	Residue
B	ARG30
B	TYR75
B	PRO104
B	PHE114
B	LYS116

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PNH C 247

Chain	Residue
C	PRO104
C	LYS116
C	ARG30

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PNH D 247

Chain	Residue
D	ARG30
D	MET97
D	PHE114
D	LYS116

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Schiff-base intermediate with acetoacetate => ECO:0000255|HAMAP-Rule:MF_00597, ECO:0000269|PubMed:19458715

Chain	Residue	Details
A	LYS116
B	LYS116
C	LYS116
D	LYS116

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site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Important for activity => ECO:0000305|PubMed:19458715

Chain	Residue	Details
A	LYS117
B	LYS117
C	LYS117
D	LYS117

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