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3BGR

Crystal structure of K103N/Y181C mutant HIV-1 reverse transcriptase (RT) in complex with TMC278 (Rilpivirine), a non-nucleoside RT inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0003676molecular_functionnucleic acid binding
A0003964molecular_functionRNA-directed DNA polymerase activity
A0004523molecular_functionRNA-DNA hybrid ribonuclease activity
A0006278biological_processRNA-templated DNA biosynthetic process
B0003964molecular_functionRNA-directed DNA polymerase activity
B0006278biological_processRNA-templated DNA biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE T27 A 556
ChainResidue
ALEU100
ALEU234
AHIS235
APRO236
ATYR318
AHOH780
BGLU138
ALYS101
AASN103
AVAL179
ACYS181
ATYR183
ATYR188
APHE227
ATRP229

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO B 429
ChainResidue
BGLU399
BTRP402
BHOH509

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING:
ChainResidueDetails
BASP110
BASP185
BASP186

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Essential for RT p66/p51 heterodimerization
ChainResidueDetails
BTRP401
BTRP414
AASP498
AASP549

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Essential for RT p66/p51 heterodimerization
ChainResidueDetails
ATRP401
ATRP414

site_idSWS_FT_FI4
Number of Residues1
DetailsSITE: Cleavage; by viral protease; partial
ChainResidueDetails
APHE440

230083

PDB entries from 2025-01-15

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