3BFX
Crystal structure of human sulfotransferase SULT1C1 in complex with PAP
Replaces: 2ETGReplaces: 1ZHEFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004062 | molecular_function | aryl sulfotransferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005764 | cellular_component | lysosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0006790 | biological_process | sulfur compound metabolic process |
| A | 0008146 | molecular_function | sulfotransferase activity |
| A | 0009308 | biological_process | amine metabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0051922 | molecular_function | cholesterol sulfotransferase activity |
| A | 0051923 | biological_process | sulfation |
| B | 0004062 | molecular_function | aryl sulfotransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005764 | cellular_component | lysosome |
| B | 0005829 | cellular_component | cytosol |
| B | 0006790 | biological_process | sulfur compound metabolic process |
| B | 0008146 | molecular_function | sulfotransferase activity |
| B | 0009308 | biological_process | amine metabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0051922 | molecular_function | cholesterol sulfotransferase activity |
| B | 0051923 | biological_process | sulfation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE A3P A 4000 |
| Chain | Residue |
| A | LYS49 |
| A | THR228 |
| A | SER229 |
| A | PHE230 |
| A | MET233 |
| A | MET257 |
| A | ARG258 |
| A | LYS259 |
| A | GLY260 |
| A | HOH4009 |
| A | HOH4011 |
| A | ALA50 |
| A | HOH4015 |
| A | HOH4019 |
| A | HOH4025 |
| A | HOH4058 |
| A | GLY51 |
| A | THR52 |
| A | THR53 |
| A | TRP54 |
| A | ARG131 |
| A | SER139 |
| A | TYR194 |
| site_id | AC2 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE A3P A 4001 |
| Chain | Residue |
| A | HOH4017 |
| A | HOH4026 |
| A | HOH4042 |
| A | HOH4100 |
| A | HOH4120 |
| B | LYS49 |
| B | ALA50 |
| B | GLY51 |
| B | THR52 |
| B | THR53 |
| B | TRP54 |
| B | ARG131 |
| B | SER139 |
| B | TYR194 |
| B | THR228 |
| B | PHE230 |
| B | MET233 |
| B | PHE256 |
| B | MET257 |
| B | ARG258 |
| B | LYS259 |
| B | GLY260 |
| B | HOH348 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 34 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16804942","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9D939","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
