3BFF

class A beta-lactamase SED-G238C complexed with faropenem

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0030655	biological_process	beta-lactam antibiotic catabolic process
A	0046677	biological_process	response to antibiotic
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0030655	biological_process	beta-lactam antibiotic catabolic process
B	0046677	biological_process	response to antibiotic
C	0008800	molecular_function	beta-lactamase activity
C	0016787	molecular_function	hydrolase activity
C	0017001	biological_process	antibiotic catabolic process
C	0030655	biological_process	beta-lactam antibiotic catabolic process
C	0046677	biological_process	response to antibiotic
D	0008800	molecular_function	beta-lactamase activity
D	0016787	molecular_function	hydrolase activity
D	0017001	biological_process	antibiotic catabolic process
D	0030655	biological_process	beta-lactam antibiotic catabolic process
D	0046677	biological_process	response to antibiotic

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SCN B 1

Chain	Residue
B	ILE49
B	LYS188
B	ARG191
B	LYS192
B	HOH758

---

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SCN A 2

Chain	Residue
A	ALA223
A	LYS284

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SCN B 3

Chain	Residue
B	ARG61
B	HOH829

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SCN B 4

Chain	Residue
B	MET95
B	THR96
B	HOH875
C	HOH349
C	HOH547

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SCN C 5

Chain	Residue
C	PRO174
C	GLY175
C	HOH445

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SCN D 6

Chain	Residue
D	ARG256
D	HOH787

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE FPM C 1

Chain	Residue
B	ALA140
B	HIS141
C	MET95
C	THR96
C	LYS137
C	ALA140
C	HIS141
C	HOH339
C	HOH390

---

site_id	AC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE SFR A 301

Chain	Residue
A	CYS69
A	SER70
A	LYS73
A	TRP105
A	SER130
A	ASN132
A	GLU166
A	ASN170
A	LYS234
A	THR235
A	GLY236
A	ALA237
A	HOH361
A	HOH451
A	HOH598

---

site_id	AC9
Number of Residues	13
Details	BINDING SITE FOR RESIDUE SFR B 302

Chain	Residue
B	CYS69
B	SER70
B	TRP105
B	SER130
B	ASN132
B	GLU166
B	ASN170
B	THR235
B	GLY236
B	ALA237
B	HOH612
B	HOH629
B	HOH697

---

site_id	BC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SFR C 303

Chain	Residue
A	HOH590
C	CYS69
C	SER70
C	LYS73
C	TRP105
C	SER130
C	ASN132
C	GLU166
C	ASN170
C	THR235
C	GLY236
C	ALA237
C	HOH389
C	HOH564

---

site_id	BC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE SFR D 304

Chain	Residue
D	CYS69
D	SER70
D	LYS73
D	TRP105
D	SER130
D	ASN132
D	GLU166
D	ASN170
D	THR216
D	THR235
D	GLY236
D	ALA237
D	HOH670
D	HOH671

---

Functional Information from PROSITE/UniProt

site_id	PS00146
Number of Residues	16
Details	BETA_LACTAMASE_A Beta-lactamase class-A active site. FaMCSTsKvmtAAAVL

Chain	Residue	Details
A	PHE66-LEU81

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1btl

Chain	Residue	Details
A	GLU166
A	LYS73
A	SER130
A	SER70

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1btl

Chain	Residue	Details
B	GLU166
B	LYS73
B	SER130
B	SER70

---

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1btl

Chain	Residue	Details
C	GLU166
C	LYS73
C	SER130
C	SER70

---

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1btl

Chain	Residue	Details
D	GLU166
D	LYS73
D	SER130
D	SER70

---