3BF5
Crystal structure of putative ribokinase (10640157) from Thermoplasma acidophilum at 1.91 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004001 | molecular_function | adenosine kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0006167 | biological_process | AMP biosynthetic process |
| A | 0008617 | biological_process | guanosine metabolic process |
| A | 0008906 | molecular_function | inosine kinase activity |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0009224 | biological_process | CMP biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016310 | biological_process | phosphorylation |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019206 | molecular_function | nucleoside kinase activity |
| A | 0043771 | molecular_function | cytidine kinase activity |
| A | 0046085 | biological_process | adenosine metabolic process |
| A | 0046087 | biological_process | cytidine metabolic process |
| A | 0046102 | biological_process | inosine metabolic process |
| A | 0106366 | molecular_function | guanosine kinase activity |
| A | 1901293 | biological_process | nucleoside phosphate biosynthetic process |
| A | 1905108 | molecular_function | guanosine binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004001 | molecular_function | adenosine kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0006167 | biological_process | AMP biosynthetic process |
| B | 0008617 | biological_process | guanosine metabolic process |
| B | 0008906 | molecular_function | inosine kinase activity |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0009224 | biological_process | CMP biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016310 | biological_process | phosphorylation |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019206 | molecular_function | nucleoside kinase activity |
| B | 0043771 | molecular_function | cytidine kinase activity |
| B | 0046085 | biological_process | adenosine metabolic process |
| B | 0046087 | biological_process | cytidine metabolic process |
| B | 0046102 | biological_process | inosine metabolic process |
| B | 0106366 | molecular_function | guanosine kinase activity |
| B | 1901293 | biological_process | nucleoside phosphate biosynthetic process |
| B | 1905108 | molecular_function | guanosine binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 B 288 |
| Chain | Residue |
| A | ARG241 |
| A | SER242 |
| A | LYS245 |
| B | ARG241 |
| B | SER242 |
| B | LYS245 |
| B | HOH358 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGO A 288 |
| Chain | Residue |
| A | ALA112 |
| A | GLY130 |
| A | GLU151 |
| A | LYS154 |
| A | GLN108 |
| A | MSE111 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PGO B 289 |
| Chain | Residue |
| B | THR64 |
| B | SER89 |
| B | HOH301 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGO B 290 |
| Chain | Residue |
| B | MSE62 |
| B | GLU73 |
| B | ASP271 |
| B | ARG274 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGO A 289 |
| Chain | Residue |
| A | GLN150 |
| A | ASN173 |
| A | HIS175 |
| A | GLU176 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGO B 291 |
| Chain | Residue |
| B | PRO189 |
| B | MSE206 |
| B | ASP207 |
| B | GLY208 |
| B | HOH355 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PGO A 290 |
| Chain | Residue |
| A | THR196 |
| A | GLY198 |
| A | GLY201 |
| A | PHE229 |
| A | HOH295 |
| A | HOH406 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PGO B 292 |
| Chain | Residue |
| B | TYR168 |
| B | THR192 |
| B | MSE206 |
| B | ILE243 |
| B | HOH356 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"Q57849","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q57849","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"Q57849","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1rk2 |
| Chain | Residue | Details |
| A | GLY226 | |
| A | GLY224 | |
| A | ALA225 | |
| A | ASP227 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1rk2 |
| Chain | Residue | Details |
| B | GLY226 | |
| B | GLY224 | |
| B | ALA225 | |
| B | ASP227 |
