3BEH
Structure of a Bacterial Cyclic Nucleotide Regulated Ion Channel
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005221 | molecular_function | intracellularly cyclic nucleotide-activated monoatomic cation channel activity |
| A | 0005267 | molecular_function | potassium channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0030552 | molecular_function | cAMP binding |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005221 | molecular_function | intracellularly cyclic nucleotide-activated monoatomic cation channel activity |
| B | 0005267 | molecular_function | potassium channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0030552 | molecular_function | cAMP binding |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005221 | molecular_function | intracellularly cyclic nucleotide-activated monoatomic cation channel activity |
| C | 0005267 | molecular_function | potassium channel activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006813 | biological_process | potassium ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0030552 | molecular_function | cAMP binding |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0044877 | molecular_function | protein-containing complex binding |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0071805 | biological_process | potassium ion transmembrane transport |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005221 | molecular_function | intracellularly cyclic nucleotide-activated monoatomic cation channel activity |
| D | 0005267 | molecular_function | potassium channel activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006813 | biological_process | potassium ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0030552 | molecular_function | cAMP binding |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0044877 | molecular_function | protein-containing complex binding |
| D | 0055085 | biological_process | transmembrane transport |
| D | 0071805 | biological_process | potassium ion transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 356 |
| Chain | Residue |
| A | TYR178 |
| A | K357 |
| A | K360 |
| B | TYR178 |
| C | TYR178 |
| D | TYR178 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE K A 357 |
| Chain | Residue |
| A | K358 |
| B | THR176 |
| B | GLY177 |
| C | THR176 |
| C | GLY177 |
| D | THR176 |
| D | GLY177 |
| A | THR176 |
| A | GLY177 |
| A | K356 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE K A 358 |
| Chain | Residue |
| A | THR175 |
| A | THR176 |
| A | K357 |
| B | THR175 |
| B | THR176 |
| B | K356 |
| C | THR175 |
| C | THR176 |
| D | THR175 |
| D | THR176 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K A 360 |
| Chain | Residue |
| A | TYR178 |
| A | K356 |
| B | TYR178 |
| C | TYR178 |
| D | TYR178 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 356 |
| Chain | Residue |
| A | THR175 |
| A | K358 |
| B | THR175 |
| C | THR175 |
| D | THR175 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE LDA A 359 |
| Chain | Residue |
| A | PRO163 |
| A | VAL170 |
| B | PHE186 |
| B | ARG189 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE LDA C 357 |
| Chain | Residue |
| B | PRO163 |
| B | GLN164 |
| C | ARG189 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE LDA D 356 |
| Chain | Residue |
| C | PRO163 |
| D | GLN184 |
| D | ARG189 |
| D | GLY193 |
| D | MET197 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE LDA D 357 |
| Chain | Residue |
| A | PHE186 |
| D | PRO163 |
Functional Information from PROSITE/UniProt
| site_id | PS00888 |
| Number of Residues | 17 |
| Details | CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. ICrIGEpGDrMFFVveG |
| Chain | Residue | Details |
| A | ILE262-GLY278 |
| site_id | PS00889 |
| Number of Residues | 18 |
| Details | CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGEmALisgep......RSAtVsA |
| Chain | Residue | Details |
| A | PHE296-ALA313 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 68 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 84 |
| Details | Topological domain: {"description":"Periplasmic"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 88 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 112 |
| Details | Topological domain: {"description":"Cytoplasmic"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 76 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 68 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 80 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 72 |
| Details | Intramembrane: {"description":"Pore-forming"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 96 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | Motif: {"description":"Selectivity filter","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
