Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3B7U

Leukotriene A4 Hydrolase Complexed with KELatorphan

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0003723	molecular_function	RNA binding
X	0004177	molecular_function	aminopeptidase activity
X	0004301	molecular_function	epoxide hydrolase activity
X	0004463	molecular_function	leukotriene-A4 hydrolase activity
X	0005515	molecular_function	protein binding
X	0005576	cellular_component	extracellular region
X	0005634	cellular_component	nucleus
X	0005737	cellular_component	cytoplasm
X	0005829	cellular_component	cytosol
X	0006508	biological_process	proteolysis
X	0006629	biological_process	lipid metabolic process
X	0006691	biological_process	leukotriene metabolic process
X	0008233	molecular_function	peptidase activity
X	0008237	molecular_function	metallopeptidase activity
X	0008270	molecular_function	zinc ion binding
X	0010043	biological_process	response to zinc ion
X	0016787	molecular_function	hydrolase activity
X	0019370	biological_process	leukotriene biosynthetic process
X	0043171	biological_process	peptide catabolic process
X	0043434	biological_process	response to peptide hormone
X	0045148	molecular_function	tripeptide aminopeptidase activity
X	0046872	molecular_function	metal ion binding
X	0060509	biological_process	type I pneumocyte differentiation
X	0070006	molecular_function	metalloaminopeptidase activity
X	0070062	cellular_component	extracellular exosome
X	1904724	cellular_component	tertiary granule lumen
X	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN X 701

Chain	Residue
X	HIS295
X	HIS299
X	GLU318

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE YB X 702

Chain	Residue
X	ASP47
X	ASP481
X	HOH747
X	HOH771

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE YB X 703

Chain	Residue
X	HOH1085
X	ASP426
X	ASP610

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE YB X 704

Chain	Residue
X	ASP175
X	HOH1081

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE IMD X 705

Chain	Residue
X	GLY344
X	GLY347
X	GLU348
X	ASN351
X	GLU501
X	ALA504
X	GLN508

site_id	AC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE KEL X 707

Chain	Residue
X	TYR267
X	GLY268
X	GLY269
X	GLU271
X	ASN291
X	HIS295
X	GLU296
X	HIS299
X	GLU318
X	TYR378
X	TYR383
X	ARG563
X	LYS565
X	HOH734
X	HOH822
X	HOH958
X	HOH969

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACY X 706

Chain	Residue
X	ASP47
X	ASN48
X	ARG174
X	LYS479
X	ASP481
X	HOH741
X	HOH771

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VIAHEISHSW

Chain	Residue	Details
X	VAL292-TRP301

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"11675384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12207002","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24591641","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1H19","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"11675384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12207002","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24591641","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1H19","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18804029","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11175901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11675384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11917124","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12207002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15078870","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18804029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19618939","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24591641","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GW6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H19","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R59","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VJ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FH7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FH8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3U9W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DPR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L2L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AEN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11175901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24591641","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1GW6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1H19","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1HS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1SQM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2R59","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VJ8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CHS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FH5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FH7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FH8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FHE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FU6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FUN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3U9W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DPR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4L2L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AEN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Pro-Gly-Pro binding","evidences":[{"source":"PubMed","id":"24591641","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Site: {"description":"Essential for epoxide hydrolase activity, but not for aminopeptidase activity","evidences":[{"source":"PubMed","id":"11917124","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Site: {"description":"Covalently modified during suicide inhibition by leukotrienes","evidences":[{"source":"PubMed","id":"7667299","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"9395533","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1h19

Chain	Residue	Details
X	TYR383
X	GLU296
X	GLU271

site_id	MCSA1
Number of Residues	7
Details	M-CSA 166

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)