Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004111 | molecular_function | creatine kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0016020 | cellular_component | membrane |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| A | 0021762 | biological_process | substantia nigra development |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0046314 | biological_process | phosphocreatine biosynthetic process |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0140651 | biological_process | futile creatine cycle |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004111 | molecular_function | creatine kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0016020 | cellular_component | membrane |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| B | 0021762 | biological_process | substantia nigra development |
| B | 0031625 | molecular_function | ubiquitin protein ligase binding |
| B | 0046314 | biological_process | phosphocreatine biosynthetic process |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0140651 | biological_process | futile creatine cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 600 |
| Chain | Residue |
| B | ADP601 |
| B | NO3602 |
| B | HOH979 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE NO3 B 602 |
| Chain | Residue |
| B | CRN603 |
| B | HOH795 |
| B | HOH979 |
| B | ARG132 |
| B | GLU232 |
| B | ARG236 |
| B | ARG320 |
| B | MG600 |
| B | ADP601 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT B 604 |
| Chain | Residue |
| A | PRO200 |
| B | ASP268 |
| B | HOH964 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 605 |
| Chain | Residue |
| A | ASN222 |
| A | LYS223 |
| A | THR224 |
| A | LYS242 |
| A | HOH945 |
| site_id | AC5 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE ADP B 601 |
| Chain | Residue |
| B | SER128 |
| B | ARG130 |
| B | ARG132 |
| B | HIS191 |
| B | ARG292 |
| B | GLY294 |
| B | VAL295 |
| B | HIS296 |
| B | ARG320 |
| B | THR322 |
| B | GLY323 |
| B | GLY324 |
| B | VAL325 |
| B | ASP335 |
| B | MG600 |
| B | NO3602 |
| B | HOH773 |
| B | HOH775 |
| B | HOH804 |
| B | HOH819 |
| B | HOH935 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CRN B 603 |
| Chain | Residue |
| B | THR71 |
| B | VAL72 |
| B | LEU201 |
| B | GLU232 |
| B | CYS283 |
| B | SER285 |
| B | NO3602 |
| B | HOH780 |
| B | HOH792 |
| B | HOH801 |
| B | HOH934 |
| B | HOH974 |
Functional Information from PROSITE/UniProt
| site_id | PS00112 |
| Number of Residues | 7 |
| Details | PHOSPHAGEN_KINASE Phosphagen kinase active site signature. CP.SNLGT |
| Chain | Residue | Details |
| A | CYS283-THR289 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 174 |
| Details | Domain: {"description":"Phosphagen kinase N-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00842","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 484 |
| Details | Domain: {"description":"Phosphagen kinase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00843","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 52 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | Region: {"description":"Internal MTS-like signal","evidences":[{"source":"UniProtKB","id":"Q04447","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 28 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 38 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18977227","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q04447","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"Q04447","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P07335","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q04447","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI13 |
| Number of Residues | 10 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"33268465","evidenceCode":"ECO:0000269"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1bg0 |
| Chain | Residue | Details |
| A | ARG236 | |
| A | ARG292 | |
| A | ARG320 | |
| A | ARG132 | |
| A | GLU232 | |
| site_id | CSA2 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1bg0 |
| Chain | Residue | Details |
| B | ARG236 | |
| B | ARG292 | |
| B | ARG320 | |
| B | ARG132 | |
| B | GLU232 | |
