3B62

EmrE multidrug transporter in complex with P4P, P21 crystal form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0006805	biological_process	xenobiotic metabolic process
A	0006970	biological_process	response to osmotic stress
A	0006974	biological_process	DNA damage response
A	0009410	biological_process	response to xenobiotic stimulus
A	0015199	molecular_function	amino-acid betaine transmembrane transporter activity
A	0015220	molecular_function	choline transmembrane transporter activity
A	0015297	molecular_function	antiporter activity
A	0015871	biological_process	choline transport
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0031460	biological_process	glycine betaine transport
A	0042802	molecular_function	identical protein binding
A	0042908	biological_process	xenobiotic transport
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
A	0071466	biological_process	cellular response to xenobiotic stimulus
A	1990207	cellular_component	EmrE multidrug transporter complex
A	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
B	0005886	cellular_component	plasma membrane
B	0006805	biological_process	xenobiotic metabolic process
B	0006970	biological_process	response to osmotic stress
B	0006974	biological_process	DNA damage response
B	0009410	biological_process	response to xenobiotic stimulus
B	0015199	molecular_function	amino-acid betaine transmembrane transporter activity
B	0015220	molecular_function	choline transmembrane transporter activity
B	0015297	molecular_function	antiporter activity
B	0015871	biological_process	choline transport
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0031460	biological_process	glycine betaine transport
B	0042802	molecular_function	identical protein binding
B	0042908	biological_process	xenobiotic transport
B	0042910	molecular_function	xenobiotic transmembrane transporter activity
B	0055085	biological_process	transmembrane transport
B	0071466	biological_process	cellular response to xenobiotic stimulus
B	1990207	cellular_component	EmrE multidrug transporter complex
B	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
C	0005886	cellular_component	plasma membrane
C	0006805	biological_process	xenobiotic metabolic process
C	0006970	biological_process	response to osmotic stress
C	0006974	biological_process	DNA damage response
C	0009410	biological_process	response to xenobiotic stimulus
C	0015199	molecular_function	amino-acid betaine transmembrane transporter activity
C	0015220	molecular_function	choline transmembrane transporter activity
C	0015297	molecular_function	antiporter activity
C	0015871	biological_process	choline transport
C	0016020	cellular_component	membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0031460	biological_process	glycine betaine transport
C	0042802	molecular_function	identical protein binding
C	0042908	biological_process	xenobiotic transport
C	0042910	molecular_function	xenobiotic transmembrane transporter activity
C	0055085	biological_process	transmembrane transport
C	0071466	biological_process	cellular response to xenobiotic stimulus
C	1990207	cellular_component	EmrE multidrug transporter complex
C	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
D	0005886	cellular_component	plasma membrane
D	0006805	biological_process	xenobiotic metabolic process
D	0006970	biological_process	response to osmotic stress
D	0006974	biological_process	DNA damage response
D	0009410	biological_process	response to xenobiotic stimulus
D	0015199	molecular_function	amino-acid betaine transmembrane transporter activity
D	0015220	molecular_function	choline transmembrane transporter activity
D	0015297	molecular_function	antiporter activity
D	0015871	biological_process	choline transport
D	0016020	cellular_component	membrane
D	0022857	molecular_function	transmembrane transporter activity
D	0031460	biological_process	glycine betaine transport
D	0042802	molecular_function	identical protein binding
D	0042908	biological_process	xenobiotic transport
D	0042910	molecular_function	xenobiotic transmembrane transporter activity
D	0055085	biological_process	transmembrane transport
D	0071466	biological_process	cellular response to xenobiotic stimulus
D	1990207	cellular_component	EmrE multidrug transporter complex
D	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE P4P A 350

Chain	Residue
A	PHE44

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE P4P C 750

Chain	Residue
C	PHE44

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	72
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"17005200","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"17005200","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Site: {"description":"Essential for translocation and for substrate and proton binding","evidences":[{"source":"PubMed","id":"12590142","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"29114048","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Site: {"description":"Involved in substrate binding"}

Chain

Residue

Details

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