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3B62

EmrE multidrug transporter in complex with P4P, P21 crystal form

Functional Information from GO Data
ChainGOidnamespacecontents
A0005886cellular_componentplasma membrane
A0006805biological_processxenobiotic metabolic process
A0006970biological_processresponse to osmotic stress
A0006974biological_processDNA damage response
A0009410biological_processresponse to xenobiotic stimulus
A0015199molecular_functionamino-acid betaine transmembrane transporter activity
A0015220molecular_functioncholine transmembrane transporter activity
A0015297molecular_functionantiporter activity
A0015871biological_processcholine transport
A0016020cellular_componentmembrane
A0022857molecular_functiontransmembrane transporter activity
A0031460biological_processglycine betaine transport
A0042802molecular_functionidentical protein binding
A0042908biological_processxenobiotic transport
A0042910molecular_functionxenobiotic transmembrane transporter activity
A0055085biological_processtransmembrane transport
A0071466biological_processcellular response to xenobiotic stimulus
A1990207cellular_componentEmrE multidrug transporter complex
A1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
B0005886cellular_componentplasma membrane
B0006805biological_processxenobiotic metabolic process
B0006970biological_processresponse to osmotic stress
B0006974biological_processDNA damage response
B0009410biological_processresponse to xenobiotic stimulus
B0015199molecular_functionamino-acid betaine transmembrane transporter activity
B0015220molecular_functioncholine transmembrane transporter activity
B0015297molecular_functionantiporter activity
B0015871biological_processcholine transport
B0016020cellular_componentmembrane
B0022857molecular_functiontransmembrane transporter activity
B0031460biological_processglycine betaine transport
B0042802molecular_functionidentical protein binding
B0042908biological_processxenobiotic transport
B0042910molecular_functionxenobiotic transmembrane transporter activity
B0055085biological_processtransmembrane transport
B0071466biological_processcellular response to xenobiotic stimulus
B1990207cellular_componentEmrE multidrug transporter complex
B1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
C0005886cellular_componentplasma membrane
C0006805biological_processxenobiotic metabolic process
C0006970biological_processresponse to osmotic stress
C0006974biological_processDNA damage response
C0009410biological_processresponse to xenobiotic stimulus
C0015199molecular_functionamino-acid betaine transmembrane transporter activity
C0015220molecular_functioncholine transmembrane transporter activity
C0015297molecular_functionantiporter activity
C0015871biological_processcholine transport
C0016020cellular_componentmembrane
C0022857molecular_functiontransmembrane transporter activity
C0031460biological_processglycine betaine transport
C0042802molecular_functionidentical protein binding
C0042908biological_processxenobiotic transport
C0042910molecular_functionxenobiotic transmembrane transporter activity
C0055085biological_processtransmembrane transport
C0071466biological_processcellular response to xenobiotic stimulus
C1990207cellular_componentEmrE multidrug transporter complex
C1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
D0005886cellular_componentplasma membrane
D0006805biological_processxenobiotic metabolic process
D0006970biological_processresponse to osmotic stress
D0006974biological_processDNA damage response
D0009410biological_processresponse to xenobiotic stimulus
D0015199molecular_functionamino-acid betaine transmembrane transporter activity
D0015220molecular_functioncholine transmembrane transporter activity
D0015297molecular_functionantiporter activity
D0015871biological_processcholine transport
D0016020cellular_componentmembrane
D0022857molecular_functiontransmembrane transporter activity
D0031460biological_processglycine betaine transport
D0042802molecular_functionidentical protein binding
D0042908biological_processxenobiotic transport
D0042910molecular_functionxenobiotic transmembrane transporter activity
D0055085biological_processtransmembrane transport
D0071466biological_processcellular response to xenobiotic stimulus
D1990207cellular_componentEmrE multidrug transporter complex
D1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
Functional Information from PDB Data
site_idAC1
Number of Residues1
DetailsBINDING SITE FOR RESIDUE P4P A 350
ChainResidue
APHE44

site_idAC2
Number of Residues1
DetailsBINDING SITE FOR RESIDUE P4P C 750
ChainResidue
CPHE44

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues68
DetailsTRANSMEM: Helical; Name=1 => ECO:0000305|PubMed:17005200
ChainResidueDetails
ATYR4-MET21
BTYR4-MET21
CTYR4-MET21
DTYR4-MET21

site_idSWS_FT_FI2
Number of Residues72
DetailsTRANSMEM: Helical; Name=2 => ECO:0000305|PubMed:17005200
ChainResidueDetails
AVAL34-ALA52
BVAL34-ALA52
CVAL34-ALA52
DVAL34-ALA52

site_idSWS_FT_FI3
Number of Residues88
DetailsTRANSMEM: Helical; Name=3 => ECO:0000305|PubMed:17005200
ChainResidueDetails
AILE58-GLY80
BILE58-GLY80
CILE58-GLY80
DILE58-GLY80

site_idSWS_FT_FI4
Number of Residues68
DetailsTRANSMEM: Helical; Name=4 => ECO:0000305|PubMed:17005200
ChainResidueDetails
AALA87-LEU104
BALA87-LEU104
CALA87-LEU104
DALA87-LEU104

site_idSWS_FT_FI5
Number of Residues4
DetailsSITE: Required for proper coupling between the substrate transport and the proton gradient
ChainResidueDetails
ATYR4
BTYR4
CTYR4
DTYR4

site_idSWS_FT_FI6
Number of Residues4
DetailsSITE: Essential for translocation and for substrate and proton binding => ECO:0000305|PubMed:12590142, ECO:0000305|PubMed:29114048
ChainResidueDetails
AGLU14
BGLU14
CGLU14
DGLU14

site_idSWS_FT_FI7
Number of Residues12
DetailsSITE: Involved in substrate binding
ChainResidueDetails
ATYR40
DTYR40
DTYR60
DTRP63
ATYR60
ATRP63
BTYR40
BTYR60
BTRP63
CTYR40
CTYR60
CTRP63

site_idSWS_FT_FI8
Number of Residues4
DetailsSITE: Important for activity => ECO:0000305|PubMed:30287687
ChainResidueDetails
AHIS110
BHIS110
CHIS110
DHIS110

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PDB entries from 2024-07-24

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