Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3B61

EmrE multidrug transporter, apo crystal form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0006805	biological_process	xenobiotic metabolic process
A	0006970	biological_process	response to osmotic stress
A	0006974	biological_process	DNA damage response
A	0009410	biological_process	response to xenobiotic stimulus
A	0015199	molecular_function	amino-acid betaine transmembrane transporter activity
A	0015220	molecular_function	choline transmembrane transporter activity
A	0015297	molecular_function	antiporter activity
A	0015871	biological_process	choline transport
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0031460	biological_process	glycine betaine transport
A	0042802	molecular_function	identical protein binding
A	0042908	biological_process	xenobiotic transport
A	0042910	molecular_function	xenobiotic transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
A	0071466	biological_process	cellular response to xenobiotic stimulus
A	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
B	0005886	cellular_component	plasma membrane
B	0006805	biological_process	xenobiotic metabolic process
B	0006970	biological_process	response to osmotic stress
B	0006974	biological_process	DNA damage response
B	0009410	biological_process	response to xenobiotic stimulus
B	0015199	molecular_function	amino-acid betaine transmembrane transporter activity
B	0015220	molecular_function	choline transmembrane transporter activity
B	0015297	molecular_function	antiporter activity
B	0015871	biological_process	choline transport
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0031460	biological_process	glycine betaine transport
B	0042802	molecular_function	identical protein binding
B	0042908	biological_process	xenobiotic transport
B	0042910	molecular_function	xenobiotic transmembrane transporter activity
B	0055085	biological_process	transmembrane transport
B	0071466	biological_process	cellular response to xenobiotic stimulus
B	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
C	0005886	cellular_component	plasma membrane
C	0006805	biological_process	xenobiotic metabolic process
C	0006970	biological_process	response to osmotic stress
C	0006974	biological_process	DNA damage response
C	0009410	biological_process	response to xenobiotic stimulus
C	0015199	molecular_function	amino-acid betaine transmembrane transporter activity
C	0015220	molecular_function	choline transmembrane transporter activity
C	0015297	molecular_function	antiporter activity
C	0015871	biological_process	choline transport
C	0016020	cellular_component	membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0031460	biological_process	glycine betaine transport
C	0042802	molecular_function	identical protein binding
C	0042908	biological_process	xenobiotic transport
C	0042910	molecular_function	xenobiotic transmembrane transporter activity
C	0055085	biological_process	transmembrane transport
C	0071466	biological_process	cellular response to xenobiotic stimulus
C	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
D	0005886	cellular_component	plasma membrane
D	0006805	biological_process	xenobiotic metabolic process
D	0006970	biological_process	response to osmotic stress
D	0006974	biological_process	DNA damage response
D	0009410	biological_process	response to xenobiotic stimulus
D	0015199	molecular_function	amino-acid betaine transmembrane transporter activity
D	0015220	molecular_function	choline transmembrane transporter activity
D	0015297	molecular_function	antiporter activity
D	0015871	biological_process	choline transport
D	0016020	cellular_component	membrane
D	0022857	molecular_function	transmembrane transporter activity
D	0031460	biological_process	glycine betaine transport
D	0042802	molecular_function	identical protein binding
D	0042908	biological_process	xenobiotic transport
D	0042910	molecular_function	xenobiotic transmembrane transporter activity
D	0055085	biological_process	transmembrane transport
D	0071466	biological_process	cellular response to xenobiotic stimulus
D	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
E	0005886	cellular_component	plasma membrane
E	0006805	biological_process	xenobiotic metabolic process
E	0006970	biological_process	response to osmotic stress
E	0006974	biological_process	DNA damage response
E	0009410	biological_process	response to xenobiotic stimulus
E	0015199	molecular_function	amino-acid betaine transmembrane transporter activity
E	0015220	molecular_function	choline transmembrane transporter activity
E	0015297	molecular_function	antiporter activity
E	0015871	biological_process	choline transport
E	0016020	cellular_component	membrane
E	0022857	molecular_function	transmembrane transporter activity
E	0031460	biological_process	glycine betaine transport
E	0042802	molecular_function	identical protein binding
E	0042908	biological_process	xenobiotic transport
E	0042910	molecular_function	xenobiotic transmembrane transporter activity
E	0055085	biological_process	transmembrane transport
E	0071466	biological_process	cellular response to xenobiotic stimulus
E	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
F	0005886	cellular_component	plasma membrane
F	0006805	biological_process	xenobiotic metabolic process
F	0006970	biological_process	response to osmotic stress
F	0006974	biological_process	DNA damage response
F	0009410	biological_process	response to xenobiotic stimulus
F	0015199	molecular_function	amino-acid betaine transmembrane transporter activity
F	0015220	molecular_function	choline transmembrane transporter activity
F	0015297	molecular_function	antiporter activity
F	0015871	biological_process	choline transport
F	0016020	cellular_component	membrane
F	0022857	molecular_function	transmembrane transporter activity
F	0031460	biological_process	glycine betaine transport
F	0042802	molecular_function	identical protein binding
F	0042908	biological_process	xenobiotic transport
F	0042910	molecular_function	xenobiotic transmembrane transporter activity
F	0055085	biological_process	transmembrane transport
F	0071466	biological_process	cellular response to xenobiotic stimulus
F	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
G	0005886	cellular_component	plasma membrane
G	0006805	biological_process	xenobiotic metabolic process
G	0006970	biological_process	response to osmotic stress
G	0006974	biological_process	DNA damage response
G	0009410	biological_process	response to xenobiotic stimulus
G	0015199	molecular_function	amino-acid betaine transmembrane transporter activity
G	0015220	molecular_function	choline transmembrane transporter activity
G	0015297	molecular_function	antiporter activity
G	0015871	biological_process	choline transport
G	0016020	cellular_component	membrane
G	0022857	molecular_function	transmembrane transporter activity
G	0031460	biological_process	glycine betaine transport
G	0042802	molecular_function	identical protein binding
G	0042908	biological_process	xenobiotic transport
G	0042910	molecular_function	xenobiotic transmembrane transporter activity
G	0055085	biological_process	transmembrane transport
G	0071466	biological_process	cellular response to xenobiotic stimulus
G	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane
H	0005886	cellular_component	plasma membrane
H	0006805	biological_process	xenobiotic metabolic process
H	0006970	biological_process	response to osmotic stress
H	0006974	biological_process	DNA damage response
H	0009410	biological_process	response to xenobiotic stimulus
H	0015199	molecular_function	amino-acid betaine transmembrane transporter activity
H	0015220	molecular_function	choline transmembrane transporter activity
H	0015297	molecular_function	antiporter activity
H	0015871	biological_process	choline transport
H	0016020	cellular_component	membrane
H	0022857	molecular_function	transmembrane transporter activity
H	0031460	biological_process	glycine betaine transport
H	0042802	molecular_function	identical protein binding
H	0042908	biological_process	xenobiotic transport
H	0042910	molecular_function	xenobiotic transmembrane transporter activity
H	0055085	biological_process	transmembrane transport
H	0071466	biological_process	cellular response to xenobiotic stimulus
H	1990961	biological_process	xenobiotic detoxification by transmembrane export across the plasma membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	136
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"17005200","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	144
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"17005200","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	176
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"17005200","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	136
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"17005200","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Site: {"description":"Required for proper coupling between the substrate transport and the proton gradient"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Site: {"description":"Essential for translocation and for substrate and proton binding","evidences":[{"source":"PubMed","id":"12590142","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"29114048","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	24
Details	Site: {"description":"Involved in substrate binding"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	8
Details	Site: {"description":"Important for activity","evidences":[{"source":"PubMed","id":"30287687","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)