Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3B5W

Crystal Structure of Eschericia coli MsbA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0006869	biological_process	lipid transport
A	0008289	molecular_function	lipid binding
A	0008559	molecular_function	ABC-type xenobiotic transporter activity
A	0015437	molecular_function	lipopolysaccharide floppase activity
A	0015920	biological_process	lipopolysaccharide transport
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0034040	molecular_function	ATPase-coupled lipid transmembrane transporter activity
A	0034204	biological_process	lipid translocation
A	0042802	molecular_function	identical protein binding
A	0042908	biological_process	xenobiotic transport
A	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
A	0055085	biological_process	transmembrane transport
A	0140359	molecular_function	ABC-type transporter activity
A	1990199	cellular_component	MsbA transporter complex
B	0000166	molecular_function	nucleotide binding
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0006869	biological_process	lipid transport
B	0008289	molecular_function	lipid binding
B	0008559	molecular_function	ABC-type xenobiotic transporter activity
B	0015437	molecular_function	lipopolysaccharide floppase activity
B	0015920	biological_process	lipopolysaccharide transport
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0034040	molecular_function	ATPase-coupled lipid transmembrane transporter activity
B	0034204	biological_process	lipid translocation
B	0042802	molecular_function	identical protein binding
B	0042908	biological_process	xenobiotic transport
B	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
B	0055085	biological_process	transmembrane transport
B	0140359	molecular_function	ABC-type transporter activity
B	1990199	cellular_component	MsbA transporter complex
C	0000166	molecular_function	nucleotide binding
C	0005524	molecular_function	ATP binding
C	0005886	cellular_component	plasma membrane
C	0006869	biological_process	lipid transport
C	0008289	molecular_function	lipid binding
C	0008559	molecular_function	ABC-type xenobiotic transporter activity
C	0015437	molecular_function	lipopolysaccharide floppase activity
C	0015920	biological_process	lipopolysaccharide transport
C	0016020	cellular_component	membrane
C	0016887	molecular_function	ATP hydrolysis activity
C	0034040	molecular_function	ATPase-coupled lipid transmembrane transporter activity
C	0034204	biological_process	lipid translocation
C	0042802	molecular_function	identical protein binding
C	0042908	biological_process	xenobiotic transport
C	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
C	0055085	biological_process	transmembrane transport
C	0140359	molecular_function	ABC-type transporter activity
C	1990199	cellular_component	MsbA transporter complex
D	0000166	molecular_function	nucleotide binding
D	0005524	molecular_function	ATP binding
D	0005886	cellular_component	plasma membrane
D	0006869	biological_process	lipid transport
D	0008289	molecular_function	lipid binding
D	0008559	molecular_function	ABC-type xenobiotic transporter activity
D	0015437	molecular_function	lipopolysaccharide floppase activity
D	0015920	biological_process	lipopolysaccharide transport
D	0016020	cellular_component	membrane
D	0016887	molecular_function	ATP hydrolysis activity
D	0034040	molecular_function	ATPase-coupled lipid transmembrane transporter activity
D	0034204	biological_process	lipid translocation
D	0042802	molecular_function	identical protein binding
D	0042908	biological_process	xenobiotic transport
D	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
D	0055085	biological_process	transmembrane transport
D	0140359	molecular_function	ABC-type transporter activity
D	1990199	cellular_component	MsbA transporter complex
E	0000166	molecular_function	nucleotide binding
E	0005524	molecular_function	ATP binding
E	0005886	cellular_component	plasma membrane
E	0006869	biological_process	lipid transport
E	0008289	molecular_function	lipid binding
E	0008559	molecular_function	ABC-type xenobiotic transporter activity
E	0015437	molecular_function	lipopolysaccharide floppase activity
E	0015920	biological_process	lipopolysaccharide transport
E	0016020	cellular_component	membrane
E	0016887	molecular_function	ATP hydrolysis activity
E	0034040	molecular_function	ATPase-coupled lipid transmembrane transporter activity
E	0034204	biological_process	lipid translocation
E	0042802	molecular_function	identical protein binding
E	0042908	biological_process	xenobiotic transport
E	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
E	0055085	biological_process	transmembrane transport
E	0140359	molecular_function	ABC-type transporter activity
E	1990199	cellular_component	MsbA transporter complex
F	0000166	molecular_function	nucleotide binding
F	0005524	molecular_function	ATP binding
F	0005886	cellular_component	plasma membrane
F	0006869	biological_process	lipid transport
F	0008289	molecular_function	lipid binding
F	0008559	molecular_function	ABC-type xenobiotic transporter activity
F	0015437	molecular_function	lipopolysaccharide floppase activity
F	0015920	biological_process	lipopolysaccharide transport
F	0016020	cellular_component	membrane
F	0016887	molecular_function	ATP hydrolysis activity
F	0034040	molecular_function	ATPase-coupled lipid transmembrane transporter activity
F	0034204	biological_process	lipid translocation
F	0042802	molecular_function	identical protein binding
F	0042908	biological_process	xenobiotic transport
F	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
F	0055085	biological_process	transmembrane transport
F	0140359	molecular_function	ABC-type transporter activity
F	1990199	cellular_component	MsbA transporter complex
G	0000166	molecular_function	nucleotide binding
G	0005524	molecular_function	ATP binding
G	0005886	cellular_component	plasma membrane
G	0006869	biological_process	lipid transport
G	0008289	molecular_function	lipid binding
G	0008559	molecular_function	ABC-type xenobiotic transporter activity
G	0015437	molecular_function	lipopolysaccharide floppase activity
G	0015920	biological_process	lipopolysaccharide transport
G	0016020	cellular_component	membrane
G	0016887	molecular_function	ATP hydrolysis activity
G	0034040	molecular_function	ATPase-coupled lipid transmembrane transporter activity
G	0034204	biological_process	lipid translocation
G	0042802	molecular_function	identical protein binding
G	0042908	biological_process	xenobiotic transport
G	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
G	0055085	biological_process	transmembrane transport
G	0140359	molecular_function	ABC-type transporter activity
G	1990199	cellular_component	MsbA transporter complex
H	0000166	molecular_function	nucleotide binding
H	0005524	molecular_function	ATP binding
H	0005886	cellular_component	plasma membrane
H	0006869	biological_process	lipid transport
H	0008289	molecular_function	lipid binding
H	0008559	molecular_function	ABC-type xenobiotic transporter activity
H	0015437	molecular_function	lipopolysaccharide floppase activity
H	0015920	biological_process	lipopolysaccharide transport
H	0016020	cellular_component	membrane
H	0016887	molecular_function	ATP hydrolysis activity
H	0034040	molecular_function	ATPase-coupled lipid transmembrane transporter activity
H	0034204	biological_process	lipid translocation
H	0042802	molecular_function	identical protein binding
H	0042908	biological_process	xenobiotic transport
H	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
H	0055085	biological_process	transmembrane transport
H	0140359	molecular_function	ABC-type transporter activity
H	1990199	cellular_component	MsbA transporter complex

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRQRIAIARAL

Chain	Residue	Details
A	LEU481-LEU495

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	808
Details	TRANSMEM: Helical => ECO:0000255\|HAMAP-Rule:MF_01703

Chain	Residue	Details
A	VAL63-TYR83
B	VAL275-MET295
C	VAL63-TYR83
C	SER140-TYR162
C	LEU167-SER186
C	PRO253-PRO273
C	VAL275-MET295
D	VAL63-TYR83
D	SER140-TYR162
D	LEU167-SER186
D	PRO253-PRO273
A	SER140-TYR162
D	VAL275-MET295
E	VAL63-TYR83
E	SER140-TYR162
E	LEU167-SER186
E	PRO253-PRO273
E	VAL275-MET295
F	VAL63-TYR83
F	SER140-TYR162
F	LEU167-SER186
F	PRO253-PRO273
A	LEU167-SER186
F	VAL275-MET295
G	VAL63-TYR83
G	SER140-TYR162
G	LEU167-SER186
G	PRO253-PRO273
G	VAL275-MET295
H	VAL63-TYR83
H	SER140-TYR162
H	LEU167-SER186
H	PRO253-PRO273
A	PRO253-PRO273
H	VAL275-MET295
A	VAL275-MET295
B	VAL63-TYR83
B	SER140-TYR162
B	LEU167-SER186
B	PRO253-PRO273

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_01703

Chain	Residue	Details
A	GLY376
B	GLY376
C	GLY376
D	GLY376
E	GLY376
F	GLY376
G	GLY376
H	GLY376

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)