3B3C

Crystal structure of the M180A mutant of the aminopeptidase from Vibrio proteolyticus in complex with leucine phosphonic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008235	molecular_function	metalloexopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	ASP117
A	GLU152
A	HIS256
A	PLU500

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 502

Chain	Residue
A	HIS97
A	ASP117
A	ASP179
A	PLU500

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K A 600

Chain	Residue
A	CYS227
A	PLU500
A	HOH672
A	HOH680
A	GLU151

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site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SCN A 601

Chain	Residue
A	THR194
A	THR202
A	GLN203
A	LEU262
A	HOH641

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site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA A 602

Chain	Residue
A	GLN6
A	THR9

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site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 603

Chain	Residue
A	GLY24
A	SER27
A	SER28
A	ASN200
A	HOH806

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA A 604

Chain	Residue
A	TYR73
A	ASN74

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 605

Chain	Residue
A	ALA55
A	SER71
A	HOH704

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site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA A 606

Chain	Residue
A	LEU213
A	PRO214
A	SER215
A	HOH852

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA A 607

Chain	Residue
A	ALA19
A	LYS273

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site_id	BC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PLU A 500

Chain	Residue
A	HIS97
A	ASP117
A	GLU151
A	GLU152
A	ASP179
A	CYS227
A	PHE248
A	TYR251
A	HIS256
A	ZN501
A	ZN502
A	K600
A	HOH645
A	HOH662
A	HOH713

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10413478","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11401547","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8087555","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8647077","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1AMP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CP6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1FT7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1IGB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LOK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1RTQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TXR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XRY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ANP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2DEA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IQ6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2NYQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B35","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B3S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B3T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B3V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B3W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B7I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3FH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3VH9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1amp

Chain	Residue	Details
A	GLU151

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site_id	MCSA1
Number of Residues	6
Details	M-CSA 167

Chain	Residue	Details
A	HIS97	metal ligand
A	ASP117	metal ligand
A	GLU151	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	GLU152	metal ligand
A	ASP179	metal ligand
A	HIS256	metal ligand

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