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3B2E

Crystal structure of S. cerevisiae Get3 in the open conformation in complex with Get1 cytosolic domain

Functional Information from GO Data
ChainGOidnamespacecontents
A0000750biological_processpheromone-dependent signal transduction involved in conjugation with cellular fusion
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0006457biological_processprotein folding
A0006620biological_processpost-translational protein targeting to endoplasmic reticulum membrane
A0006890biological_processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
A0008270molecular_functionzinc ion binding
A0009408biological_processresponse to heat
A0010038biological_processresponse to metal ion
A0016192biological_processvesicle-mediated transport
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0034599biological_processcellular response to oxidative stress
A0042802molecular_functionidentical protein binding
A0043529cellular_componentGET complex
A0044183molecular_functionprotein folding chaperone
A0045048biological_processprotein insertion into ER membrane
A0046685biological_processresponse to arsenic-containing substance
A0046872molecular_functionmetal ion binding
A0051082molecular_functionunfolded protein binding
A0071816biological_processtail-anchored membrane protein insertion into ER membrane
B0000750biological_processpheromone-dependent signal transduction involved in conjugation with cellular fusion
B0005085molecular_functionguanyl-nucleotide exchange factor activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0006457biological_processprotein folding
B0006620biological_processpost-translational protein targeting to endoplasmic reticulum membrane
B0006890biological_processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
B0008270molecular_functionzinc ion binding
B0009408biological_processresponse to heat
B0010038biological_processresponse to metal ion
B0016192biological_processvesicle-mediated transport
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0034599biological_processcellular response to oxidative stress
B0042802molecular_functionidentical protein binding
B0043529cellular_componentGET complex
B0044183molecular_functionprotein folding chaperone
B0045048biological_processprotein insertion into ER membrane
B0046685biological_processresponse to arsenic-containing substance
B0046872molecular_functionmetal ion binding
B0051082molecular_functionunfolded protein binding
B0071816biological_processtail-anchored membrane protein insertion into ER membrane
C0000750biological_processpheromone-dependent signal transduction involved in conjugation with cellular fusion
C0005085molecular_functionguanyl-nucleotide exchange factor activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0006457biological_processprotein folding
C0006620biological_processpost-translational protein targeting to endoplasmic reticulum membrane
C0006890biological_processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
C0008270molecular_functionzinc ion binding
C0009408biological_processresponse to heat
C0010038biological_processresponse to metal ion
C0016192biological_processvesicle-mediated transport
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0034599biological_processcellular response to oxidative stress
C0042802molecular_functionidentical protein binding
C0043529cellular_componentGET complex
C0044183molecular_functionprotein folding chaperone
C0045048biological_processprotein insertion into ER membrane
C0046685biological_processresponse to arsenic-containing substance
C0046872molecular_functionmetal ion binding
C0051082molecular_functionunfolded protein binding
C0071816biological_processtail-anchored membrane protein insertion into ER membrane
D0000750biological_processpheromone-dependent signal transduction involved in conjugation with cellular fusion
D0005085molecular_functionguanyl-nucleotide exchange factor activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0006457biological_processprotein folding
D0006620biological_processpost-translational protein targeting to endoplasmic reticulum membrane
D0006890biological_processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
D0008270molecular_functionzinc ion binding
D0009408biological_processresponse to heat
D0010038biological_processresponse to metal ion
D0016192biological_processvesicle-mediated transport
D0016787molecular_functionhydrolase activity
D0016887molecular_functionATP hydrolysis activity
D0034599biological_processcellular response to oxidative stress
D0042802molecular_functionidentical protein binding
D0043529cellular_componentGET complex
D0044183molecular_functionprotein folding chaperone
D0045048biological_processprotein insertion into ER membrane
D0046685biological_processresponse to arsenic-containing substance
D0046872molecular_functionmetal ion binding
D0051082molecular_functionunfolded protein binding
D0071816biological_processtail-anchored membrane protein insertion into ER membrane
E0071816biological_processtail-anchored membrane protein insertion into ER membrane
F0071816biological_processtail-anchored membrane protein insertion into ER membrane
G0071816biological_processtail-anchored membrane protein insertion into ER membrane
H0071816biological_processtail-anchored membrane protein insertion into ER membrane
Functional Information from PDB Data
site_idAC1
Number of Residues15
DetailsBINDING SITE FOR RESIDUE ADP A 401
ChainResidue
AGLY27
ALEU316
ACYS317
AGLU320
AILE321
AARG322
APHE330
AGLY28
AVAL29
AGLY30
ALYS31
ATHR32
ATHR33
AASN272
APRO315

site_idAC2
Number of Residues14
DetailsBINDING SITE FOR RESIDUE ADP B 401
ChainResidue
BGLY27
BGLY28
BGLY30
BLYS31
BTHR32
BTHR33
BASN272
BPRO315
BLEU316
BCYS317
BGLU320
BILE321
BARG322
BPHE330

site_idAC3
Number of Residues14
DetailsBINDING SITE FOR RESIDUE ADP C 401
ChainResidue
CGLY27
CGLY28
CVAL29
CGLY30
CLYS31
CTHR32
CTHR33
CASN272
CPRO315
CLEU316
CCYS317
CGLU320
CARG322
CPHE330

site_idAC4
Number of Residues14
DetailsBINDING SITE FOR RESIDUE ADP D 401
ChainResidue
DGLY27
DGLY28
DGLY30
DLYS31
DTHR32
DTHR33
DASN272
DPRO315
DLEU316
DCYS317
DGLY319
DGLU320
DILE321
DARG322

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE:
ChainResidueDetails
AASP57
BASP57
CASP57
DASP57

site_idSWS_FT_FI2
Number of Residues16
DetailsBINDING:
ChainResidueDetails
ALYS26
CGLU245
CASN272
CPRO315
DLYS26
DGLU245
DASN272
DPRO315
AGLU245
AASN272
APRO315
BLYS26
BGLU245
BASN272
BPRO315
CLYS26

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03112, ECO:0000269|PubMed:19675567
ChainResidueDetails
ACYS285
ACYS288
BCYS285
BCYS288
CCYS285
CCYS288
DCYS285
DCYS288

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PDB entries from 2024-10-30

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