3B0U
tRNA-dihydrouridine synthase from Thermus thermophilus in complex with tRNA fragment
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| X | 0000049 | molecular_function | tRNA binding |
| X | 0000166 | molecular_function | nucleotide binding |
| X | 0002943 | biological_process | tRNA dihydrouridine synthesis |
| X | 0003723 | molecular_function | RNA binding |
| X | 0008033 | biological_process | tRNA processing |
| X | 0010181 | molecular_function | FMN binding |
| X | 0016491 | molecular_function | oxidoreductase activity |
| X | 0017150 | molecular_function | tRNA dihydrouridine synthase activity |
| X | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| X | 0102264 | molecular_function | tRNA-dihydrouridine20 synthase activity |
| X | 0102266 | molecular_function | tRNA-dihydrouridine20a synthase activity |
| Y | 0000049 | molecular_function | tRNA binding |
| Y | 0000166 | molecular_function | nucleotide binding |
| Y | 0002943 | biological_process | tRNA dihydrouridine synthesis |
| Y | 0003723 | molecular_function | RNA binding |
| Y | 0008033 | biological_process | tRNA processing |
| Y | 0010181 | molecular_function | FMN binding |
| Y | 0016491 | molecular_function | oxidoreductase activity |
| Y | 0017150 | molecular_function | tRNA dihydrouridine synthase activity |
| Y | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| Y | 0102264 | molecular_function | tRNA-dihydrouridine20 synthase activity |
| Y | 0102266 | molecular_function | tRNA-dihydrouridine20a synthase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE FMN X 400 |
| Chain | Residue |
| A | H2U20 |
| X | HIS164 |
| X | ARG178 |
| X | ASN203 |
| X | GLY204 |
| X | GLY205 |
| X | GLY225 |
| X | ARG226 |
| X | HOH351 |
| X | HOH364 |
| X | HOH367 |
| X | ALA9 |
| X | HOH417 |
| X | PRO10 |
| X | MET11 |
| X | VAL12 |
| X | MET36 |
| X | GLN63 |
| X | ASN90 |
| X | LYS132 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE FMN Y 400 |
| Chain | Residue |
| B | H2U20 |
| Y | ALA9 |
| Y | PRO10 |
| Y | MET11 |
| Y | VAL12 |
| Y | MET36 |
| Y | GLN63 |
| Y | ASN90 |
| Y | LYS132 |
| Y | HIS164 |
| Y | ARG178 |
| Y | ASN203 |
| Y | GLY205 |
| Y | GLY225 |
| Y | ARG226 |
| Y | HOH352 |
| Y | HOH355 |
| Y | HOH402 |
| Y | HOH423 |
Functional Information from PROSITE/UniProt
| site_id | PS01136 |
| Number of Residues | 19 |
| Details | UPF0034 Uncharacterized protein family UPF0034 signature. INLNlGCPsek.Aqeggy.GA |
| Chain | Residue | Details |
| X | ILE87-ALA105 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"22123979","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"22123979","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3B0P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B0U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B0V","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Site: {"description":"Interacts with tRNA","evidences":[{"source":"PubMed","id":"22123979","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Site: {"description":"Interacts with tRNA; defines subfamily-specific binding signature","evidences":[{"source":"PubMed","id":"22123979","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25902496","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
