3AZ8
Beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) from Plasmodium falciparum in complex with NAS21
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0016836 | molecular_function | hydro-lyase activity |
| B | 0006633 | biological_process | fatty acid biosynthetic process |
| B | 0016836 | molecular_function | hydro-lyase activity |
| C | 0006633 | biological_process | fatty acid biosynthetic process |
| C | 0016836 | molecular_function | hydro-lyase activity |
| D | 0006633 | biological_process | fatty acid biosynthetic process |
| D | 0016836 | molecular_function | hydro-lyase activity |
| E | 0006633 | biological_process | fatty acid biosynthetic process |
| E | 0016836 | molecular_function | hydro-lyase activity |
| F | 0006633 | biological_process | fatty acid biosynthetic process |
| F | 0016836 | molecular_function | hydro-lyase activity |
| G | 0006633 | biological_process | fatty acid biosynthetic process |
| G | 0016836 | molecular_function | hydro-lyase activity |
| H | 0006633 | biological_process | fatty acid biosynthetic process |
| H | 0016836 | molecular_function | hydro-lyase activity |
| I | 0006633 | biological_process | fatty acid biosynthetic process |
| I | 0016836 | molecular_function | hydro-lyase activity |
| J | 0006633 | biological_process | fatty acid biosynthetic process |
| J | 0016836 | molecular_function | hydro-lyase activity |
| K | 0006633 | biological_process | fatty acid biosynthetic process |
| K | 0016836 | molecular_function | hydro-lyase activity |
| L | 0006633 | biological_process | fatty acid biosynthetic process |
| L | 0016836 | molecular_function | hydro-lyase activity |
| M | 0006633 | biological_process | fatty acid biosynthetic process |
| M | 0016836 | molecular_function | hydro-lyase activity |
| N | 0006633 | biological_process | fatty acid biosynthetic process |
| N | 0016836 | molecular_function | hydro-lyase activity |
| O | 0006633 | biological_process | fatty acid biosynthetic process |
| O | 0016836 | molecular_function | hydro-lyase activity |
| P | 0006633 | biological_process | fatty acid biosynthetic process |
| P | 0016836 | molecular_function | hydro-lyase activity |
| Q | 0006633 | biological_process | fatty acid biosynthetic process |
| Q | 0016836 | molecular_function | hydro-lyase activity |
| R | 0006633 | biological_process | fatty acid biosynthetic process |
| R | 0016836 | molecular_function | hydro-lyase activity |
| S | 0006633 | biological_process | fatty acid biosynthetic process |
| S | 0016836 | molecular_function | hydro-lyase activity |
| T | 0006633 | biological_process | fatty acid biosynthetic process |
| T | 0016836 | molecular_function | hydro-lyase activity |
| U | 0006633 | biological_process | fatty acid biosynthetic process |
| U | 0016836 | molecular_function | hydro-lyase activity |
| V | 0006633 | biological_process | fatty acid biosynthetic process |
| V | 0016836 | molecular_function | hydro-lyase activity |
| W | 0006633 | biological_process | fatty acid biosynthetic process |
| W | 0016836 | molecular_function | hydro-lyase activity |
| X | 0006633 | biological_process | fatty acid biosynthetic process |
| X | 0016836 | molecular_function | hydro-lyase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1 |
| Chain | Residue |
| A | PRO101 |
| A | PHE129 |
| B | PRO101 |
| B | PRO128 |
| B | PHE129 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL D 2 |
| Chain | Residue |
| D | PHE129 |
| D | HOH284 |
| A | ASN126 |
| C | PRO101 |
| D | PRO101 |
| D | PRO128 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL F 3 |
| Chain | Residue |
| E | PHE102 |
| E | PHE129 |
| F | PRO101 |
| F | PRO128 |
| F | PHE129 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL H 4 |
| Chain | Residue |
| G | PRO101 |
| G | PHE129 |
| H | PRO101 |
| H | PHE129 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL I 5 |
| Chain | Residue |
| I | PRO101 |
| I | PHE102 |
| I | PRO128 |
| I | LEU144 |
| J | PRO101 |
| J | PHE102 |
| J | PHE129 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL L 6 |
| Chain | Residue |
| K | PRO101 |
| L | PRO101 |
| L | PHE102 |
| L | PRO128 |
| L | HOH233 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL M 7 |
| Chain | Residue |
| M | PRO101 |
| M | PHE102 |
| M | PRO128 |
| N | PRO101 |
| N | PRO128 |
| N | PHE129 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL O 8 |
| Chain | Residue |
| O | PEG28 |
| O | PRO101 |
| O | PHE129 |
| P | PHE129 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL R 9 |
| Chain | Residue |
| Q | PRO128 |
| Q | PHE129 |
| R | PRO101 |
| R | PHE102 |
| R | PHE129 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL S 10 |
| Chain | Residue |
| S | PRO101 |
| S | PRO128 |
| S | PHE129 |
| T | PRO101 |
| T | PHE102 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL U 11 |
| Chain | Residue |
| U | PRO101 |
| V | PRO101 |
| V | PRO128 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL W 12 |
| Chain | Residue |
| W | PRO101 |
| W | PRO128 |
| X | PRO101 |
| X | PRO128 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL P 13 |
| Chain | Residue |
| I | ILE118 |
| I | GLN192 |
| I | TYR212 |
| P | GLN192 |
| P | ASN194 |
| site_id | BC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE S21 R 1 |
| Chain | Residue |
| Q | HIS133 |
| Q | ILE139 |
| Q | MET140 |
| Q | PRO141 |
| Q | GLY142 |
| Q | GLN145 |
| R | HIS98 |
| R | GLU147 |
| R | GLN151 |
| R | PHE169 |
| R | LEU170 |
| R | PHE171 |
| R | HOH338 |
| site_id | BC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE S21 D 231 |
| Chain | Residue |
| C | HIS133 |
| C | ILE139 |
| C | GLY142 |
| C | TRP179 |
| C | LYS181 |
| D | HIS98 |
| D | GLU147 |
| D | PHE169 |
| D | LEU170 |
| D | PHE171 |
| D | HOH232 |
| site_id | BC7 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE S21 F 231 |
| Chain | Residue |
| F | GLN151 |
| F | PHE169 |
| F | LEU170 |
| F | PHE171 |
| E | HIS133 |
| E | ILE139 |
| E | MET140 |
| E | PRO141 |
| E | GLY142 |
| E | GLN145 |
| E | PRO182 |
| E | VAL183 |
| F | HIS98 |
| F | GLU147 |
| F | ALA150 |
| site_id | BC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE S21 P 4 |
| Chain | Residue |
| O | HIS133 |
| O | ILE139 |
| O | MET140 |
| O | GLY142 |
| O | GLN145 |
| O | TRP179 |
| O | LYS181 |
| O | PRO182 |
| O | VAL183 |
| P | HIS98 |
| P | GLU147 |
| P | PHE169 |
| P | LEU170 |
| P | PHE171 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 E 1 |
| Chain | Residue |
| E | HIS98 |
| E | GLU147 |
| E | ALA150 |
| E | PHE169 |
| E | PHE171 |
| F | HIS133 |
| site_id | CC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG C 1 |
| Chain | Residue |
| C | THR188 |
| F | THR190 |
| site_id | CC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG F 2 |
| Chain | Residue |
| F | SER86 |
| F | LYS107 |
| site_id | CC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG B 3 |
| Chain | Residue |
| B | TYR212 |
| site_id | CC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PEG H 231 |
| Chain | Residue |
| H | ASP161 |
| H | GLN164 |
| H | PHE198 |
| H | LYS199 |
| X | ASP161 |
| X | SER200 |
| site_id | CC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG G 6 |
| Chain | Residue |
| G | SER160 |
| G | ASP162 |
| site_id | CC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG Q 7 |
| Chain | Residue |
| F | ASN194 |
| Q | ASP162 |
| Q | LYS165 |
| site_id | CC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG S 8 |
| Chain | Residue |
| D | ILE118 |
| D | TYR212 |
| S | HOH57 |
| S | TYR110 |
| S | GLN192 |
| site_id | CC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG Q 9 |
| Chain | Residue |
| Q | LYS93 |
| Q | ARG99 |
| site_id | CC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PEG O 10 |
| Chain | Residue |
| O | ARG99 |
| site_id | DC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG I 11 |
| Chain | Residue |
| I | GLN192 |
| I | ASN194 |
| P | ILE118 |
| site_id | DC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG S 12 |
| Chain | Residue |
| S | LYS93 |
| S | ARG99 |
| V | PRO135 |
| site_id | DC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG S 13 |
| Chain | Residue |
| S | TYR100 |
| T | ASN131 |
| V | ASN131 |
| X | ASN131 |
| site_id | DC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG N 14 |
| Chain | Residue |
| N | SER86 |
| N | ILE87 |
| N | LYS107 |
| site_id | DC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG R 15 |
| Chain | Residue |
| Q | ALA172 |
| R | ARG178 |
| R | TRP179 |
| site_id | DC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG Q 16 |
| Chain | Residue |
| Q | ARG178 |
| R | LYS206 |
| R | THR225 |
| site_id | DC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG E 17 |
| Chain | Residue |
| E | SER160 |
| E | ASP161 |
| site_id | DC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG A 18 |
| Chain | Residue |
| A | SER86 |
| A | ASP88 |
| A | LYS107 |
| site_id | DC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PEG S 19 |
| Chain | Residue |
| D | GLN192 |
| S | ILE118 |
| S | TYR212 |
| site_id | EC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG I 20 |
| Chain | Residue |
| G | TYR100 |
| I | TYR100 |
| J | ASN131 |
| L | ASN131 |
| site_id | EC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG U 21 |
| Chain | Residue |
| U | GLN122 |
| X | THR188 |
| site_id | EC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PEG O 22 |
| Chain | Residue |
| O | ASN194 |
| O | SER208 |
| O | VAL210 |
| O | ASN220 |
| O | SER222 |
| Q | ASN214 |
| site_id | EC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG O 23 |
| Chain | Residue |
| O | LYS94 |
| O | PRO97 |
| O | ARG99 |
| O | ASN167 |
| P | GLN136 |
| site_id | EC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG F 24 |
| Chain | Residue |
| F | PEG25 |
| F | ASN114 |
| site_id | EC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG F 25 |
| Chain | Residue |
| F | PEG24 |
| F | ASN114 |
| F | SER160 |
| F | ASP161 |
| site_id | EC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG A 26 |
| Chain | Residue |
| A | PEG27 |
| A | LEU158 |
| A | ASP162 |
| A | LYS165 |
| site_id | EC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG A 27 |
| Chain | Residue |
| A | PEG26 |
| A | LYS159 |
| site_id | EC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PEG O 28 |
| Chain | Residue |
| O | GOL8 |
| O | PRO128 |
| O | ASN131 |
| O | HOH239 |
| P | PRO101 |
| P | PRO128 |
| R | TYR100 |
| site_id | FC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PEG R 29 |
| Chain | Residue |
| R | HOH31 |
| R | ASP84 |
| site_id | FC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL O 1 |
| Chain | Residue |
| O | HIS98 |
| O | GLU147 |
| O | PHE169 |
| site_id | FC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL U 2 |
| Chain | Residue |
| U | HIS98 |
| U | GLU147 |
| site_id | FC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 3 |
| Chain | Residue |
| A | HIS98 |
| A | GLU147 |
| site_id | FC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 4 |
| Chain | Residue |
| A | HIS133 |
| B | HIS98 |
| B | GLU147 |
| site_id | FC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL C 5 |
| Chain | Residue |
| C | HIS98 |
| C | GLU147 |
| site_id | FC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL H 6 |
| Chain | Residue |
| G | PHE171 |
| H | HIS133 |
| H | PRO141 |
| H | GLY142 |
| site_id | FC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL G 7 |
| Chain | Residue |
| G | GLY142 |
| H | GLU147 |
| H | PHE171 |
| site_id | FC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL I 8 |
| Chain | Residue |
| I | HIS98 |
| I | GLU147 |
| J | HIS133 |
| site_id | GC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL J 9 |
| Chain | Residue |
| J | HIS98 |
| J | GLU147 |
| J | PHE169 |
| site_id | GC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL K 10 |
| Chain | Residue |
| K | HIS98 |
| K | GLU147 |
| site_id | GC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL L 11 |
| Chain | Residue |
| L | HIS98 |
| L | GLU147 |
| L | PHE169 |
| site_id | GC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL M 12 |
| Chain | Residue |
| M | GLU147 |
| N | HOH63 |
| N | HIS133 |
| site_id | GC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL N 13 |
| Chain | Residue |
| N | HIS98 |
| N | GLU147 |
| site_id | GC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL R 14 |
| Chain | Residue |
| Q | HIS98 |
| Q | GLU147 |
| R | HIS133 |
| site_id | GC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL S 15 |
| Chain | Residue |
| S | HIS98 |
| S | GLU147 |
| T | HIS133 |
| site_id | GC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL T 16 |
| Chain | Residue |
| S | HIS133 |
| T | HIS98 |
| T | GLU147 |
| site_id | GC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL V 17 |
| Chain | Residue |
| V | HIS98 |
| V | GLU147 |
