3ATV

Crystal structure of human Hsp70 NBD in the ADP-bound and Mg ion-free state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0016887	molecular_function	ATP hydrolysis activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	29
Details	BINDING SITE FOR RESIDUE ADP A 1452

Chain	Residue
A	GLY12
A	ARG272
A	SER275
A	GLY338
A	GLY339
A	SER340
A	ARG342
A	ILE343
A	ASP366
A	HOH434
A	HOH439
A	THR13
A	HOH440
A	HOH640
A	HOH667
A	HOH668
A	HOH670
A	HOH726
A	HOH727
A	HOH728
A	HOH729
A	K1453
A	THR14
A	TYR15
A	GLY201
A	GLY202
A	GLY230
A	GLU268
A	LYS271

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K A 1453

Chain	Residue
A	ASP10
A	GLY12
A	TYR15
A	HOH724
A	HOH726
A	HOH727
A	ADP1452

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1454

Chain	Residue
A	LYS345
A	HOH682
A	HOH708

---

Functional Information from PROSITE/UniProt

site_id	PS00297
Number of Residues	8
Details	HSP70_1 Heat shock hsp70 proteins family signature 1. IDLGTTyS

Chain	Residue	Details
A	ILE9-SER16

---

site_id	PS00329
Number of Residues	14
Details	HSP70_2 Heat shock hsp70 proteins family signature 2. IFDLGGGTfdvSIL

Chain	Residue	Details
A	ILE197-LEU210

---

site_id	PS01036
Number of Residues	15
Details	HSP70_3 Heat shock hsp70 proteins family signature 3. LvLvGGsTRIPkVqK

Chain	Residue	Details
A	LEU334-LYS348

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"27708256","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---