3AQI

H240A variant of human ferrochelatase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004325	molecular_function	ferrochelatase activity
A	0006783	biological_process	heme biosynthetic process
B	0004325	molecular_function	ferrochelatase activity
B	0006783	biological_process	heme biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FES A 501

Chain	Residue
A	CYS196
A	ARG272
A	SER402
A	CYS403
A	CYS406
A	CYS411

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE CHD A 1

Chain	Residue
A	SER197
A	HIS263
A	VAL269
A	TRP310
A	HOH499
A	HOH503
A	HOH512
A	HOH551
A	HOH557
A	HOH578
A	HOH691
A	CHD2
A	LEU92
A	LEU98

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CHD A 2

Chain	Residue
A	CHD1
A	CHD3
A	MET99
A	ARG114
A	HOH518
A	HOH567
A	HOH602
A	HOH701

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CHD A 3

Chain	Residue
A	CHD2
A	HOH651
B	LYS606
B	PHE610

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 424

Chain	Residue
A	GLU80
A	GLY127
A	GLY129
A	SER130
A	HOH473
A	HOH873

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FES B 501

Chain	Residue
B	CYS696
B	ARG772
B	SER902
B	CYS903
B	CYS906
B	CYS911

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CHD B 4

Chain	Residue
B	CHD5
B	CHD6
B	HOH429
B	HOH442
B	HOH514
B	HOH517
B	MET599
B	ARG614
B	PRO766

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CHD B 5

Chain	Residue
A	LYS106
A	PHE110
B	CHD4
B	HOH517
B	HOH1023

---

site_id	AC9
Number of Residues	17
Details	BINDING SITE FOR RESIDUE CHD B 6

Chain	Residue
B	CHD4
B	HOH156
B	HOH174
B	HOH186
B	HOH293
B	HOH346
B	HOH404
B	HOH464
B	MET576
B	LEU592
B	PHE593
B	LEU598
B	SER697
B	HIS763
B	PRO766
B	VAL769
B	TRP810

---

Functional Information from PROSITE/UniProt

site_id	PS00534
Number of Residues	19
Details	FERROCHELATASE Ferrochelatase signature. ILfSaHSLPmsvv.NrGDp...Y

Chain	Residue	Details
A	ILE258-TYR276

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PubMed","id":"11175906","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17261801","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HRE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11175906","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17261801","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HRK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HRC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11175906","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1HRK","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P22315","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P22315","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	9
Details	M-CSA 578

Chain	Residue	Details
A	MET76
A	LEU92
A	LEU98
A	ARG164
A	TYR165
A	HIS263	metal ligand, proton acceptor
A	ASP340
A	GLU343	metal ligand, proton acceptor
A	GLU347

---

site_id	MCSA2
Number of Residues	9
Details	M-CSA 578

Chain	Residue	Details
B	MET576
B	LEU592
B	LEU598
B	ARG664
B	TYR665
B	HIS763	metal ligand, proton acceptor
B	ASP840
B	GLU843	metal ligand, proton acceptor
B	GLU847

---